Role of the renin-angiotensin system in hepatic ischemia reperfusion injury in rats

Hepatology ◽  
2004 ◽  
Vol 40 (3) ◽  
pp. 583-589 ◽  
Author(s):  
Luping Guo ◽  
Katharine S. Richardson ◽  
Lindsay M. Tucker ◽  
Mark A. Doll ◽  
David W. Hein ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renin Angiotensin System ◽  
Hepatic Ischemia ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Hepatic Ischemia Reperfusion

scholarly journals Role of cardiac renin angiotensin system in ischemia reperfusion injury and preconditioning of heart

2016 ◽  
Vol 68 (6) ◽  
pp. 856-861 ◽  
Author(s):  
Vimal Agrawal ◽  
Jeetendra Kumar Gupta ◽  
Shaiba Sana Qureshi ◽  
Vishal Kumar Vishwakarma
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

The role of HMGB-1 on the development of necrosis during hepatic ischemia and hepatic ischemia/reperfusion injury in mice

2005 ◽  
Vol 124 (1) ◽  
pp. 59-66 ◽  
Author(s):  
Taiji Watanabe ◽  
Sunao Kubota ◽  
Masaki Nagaya ◽  
Shoichi Ozaki ◽  
Hiroko Nagafuchi ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion

scholarly journals Dysregulation of the renin-angiotensin system during lung ischemia-reperfusion injury

2016 ◽  
Vol 42 (6) ◽  
pp. 277-285 ◽  
Author(s):  
K. Kehoe ◽  
J. F. Gielis ◽  
G. Vliegen ◽  
R. Van Elzen ◽  
R. Verkerk ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Sevoflurane relieves hepatic ischemia–reperfusion injury by inhibiting the expression of Grp78

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Di Liu ◽  
Xin Jin ◽  
Chunqi Zhang ◽  
You Shang
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Regulatory Protein ◽  
Liver Homogenate ◽  
Hepatic Ischemia ◽  
Damage Degree ◽  
Tnf Α ◽  
Hepatic Ischemia Reperfusion

Purpose: This article aimed to study the role of sevoflurane pre-conditioning in hepatic ischemia–reperfusion and its potential mechanism. Methods: Rat liver ischemia–reperfusion model was constructed. Serum TNF-α, IL-1β, IL-10, and IL-6 concentrations were detected by ELISA. Malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) in liver homogenate were determined. Hematoxylin–Eosin (HE) staining, Tunel, and immunohistochemistry were performed. Ischemia–reperfusion hepatocyte model was established. Cells transfection was conducted. Apoptosis was observed by flow cytometry. Quantitative real-time PCR (qRT-PCR) and Western blotting analysis were used. Results: Compared with I/R group, liver damage degree, liver cell apoptosis, and glucose regulatory protein 78 (Grp78) expression was obviously reduced in rats of SEV group. TNF-α, IL-1β, and IL-6 concentrations were also significantly increased (P<0.01). MDA and NO concentrations were dramatically lower (P<0.01) and SOD concentration was significantly higher (P<0.01). Apoptosis rate, Grp78, PERK, eIF2α, and p-c-JNK/JNK expression was also significantly decreased (P<0.01). Sevoflurane significantly reduced apoptosis and expression of PERK, eIF2α, p-c-JNK/JNK by inhibiting the expression of Grp78 (P<0.01). Conclusion: Sevoflurane relieves hepatic ischemia–reperfusion injury by inhibiting the expression of Grp78.

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