Chromatin remodeling of the Th2 cytokine gene loci

2005 ◽  
Vol 1285 ◽  
pp. 137-144
Author(s):  
T. Nakayama ◽  
M. Yamashita ◽  
M. Kimura ◽  
A. Hasegawa ◽  
M. Omori ◽  
...  
Keyword(s):  
Chromatin Remodeling ◽  
Cytokine Gene ◽  
Th2 Cytokine

scholarly journals Essential Role of GATA3 for the Maintenance of Type 2 Helper T (Th2) Cytokine Production and Chromatin Remodeling at the Th2 Cytokine Gene Loci

2004 ◽  
Vol 279 (26) ◽  
pp. 26983-26990 ◽  
Author(s):  
Masakatsu Yamashita ◽  
Maki Ukai-Tadenuma ◽  
Takeshi Miyamoto ◽  
Kaoru Sugaya ◽  
Hiroyuki Hosokawa ◽  
...  
Keyword(s):  
Chromatin Remodeling ◽  
Essential Role ◽  
Cytokine Production ◽  
Cytokine Gene ◽  
Th2 Cytokine

Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells

2007 ◽  
Vol 44 (9) ◽  
pp. 2249-2256 ◽  
Author(s):  
Takaaki Kaneko ◽  
Hiroyuki Hosokawa ◽  
Masakatsu Yamashita ◽  
Chrong-Reen Wang ◽  
Akihiro Hasegawa ◽  
...  
Keyword(s):  
T Cells ◽  
Chromatin Remodeling ◽  
Helper T Cells ◽  
Cytokine Gene ◽  
Human Type ◽  
Th2 Cytokine

scholarly journals MEKK1 Binds HECT E3 Ligase Itch by Its Amino-Terminal RING Motif to Regulate Th2 Cytokine Gene Expression

2009 ◽  
Vol 183 (6) ◽  
pp. 3831-3838 ◽  
Author(s):  
Thomas Enzler ◽  
Xing Chang ◽  
Valeria Facchinetti ◽  
Gerry Melino ◽  
Michael Karin ◽  
...  
Keyword(s):  
Gene Expression ◽  
E3 Ligase ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Amino Terminal ◽  
Th2 Cytokine ◽  
Ring Motif

Th1/Th2 cytokine gene polymorphisms in patients with idiopathic pulmonary fibrosis

2006 ◽  
Vol 67 (3) ◽  
pp. 229-232 ◽  
Author(s):  
M. Vasakova ◽  
I. Striz ◽  
A. Slavcev ◽  
S. Jandova ◽  
L. Kolesar ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Gene Polymorphisms ◽  
Cytokine Gene ◽  
Th2 Cytokine ◽  
Cytokine Gene Polymorphisms

Association between TH2 Cytokine Gene Polymorphisms and Risk of Bullous Pemphigoid

2020 ◽  
pp. 1-13 ◽  
Author(s):  
Pardis-Sadat Tabatabaei-Panah ◽  
Hamideh Moravvej ◽  
Marzieh Alirajab ◽  
Ahmad Etaaty ◽  
Maryam Geranmayeh ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Gene Polymorphisms ◽  
Cytokine Gene ◽  
Th2 Cytokine ◽  
Cytokine Gene Polymorphisms

scholarly journals BRG1-Mediated Chromatin Remodeling Regulates Differentiation and Gene Expression of T Helper Cells

2008 ◽  
Vol 28 (24) ◽  
pp. 7274-7285 ◽  
Author(s):  
Andrea L. Wurster ◽  
Michael J. Pazin
Keyword(s):  
Gene Expression ◽  
Cell Fate ◽  
Chromatin Remodeling ◽  
Chromatin Structure ◽  
Target Genes ◽  
T Helper Cell ◽  
T Helper ◽  
T Helper 2 ◽  
Th2 Cytokine ◽  
Th2 Differentiation

ABSTRACT During T helper cell differentiation, distinct programs of gene expression play a key role in defining the immune response to an environmental challenge. How chromatin remodeling events at the associated cytokine loci control differentiation is not known. We found that the ATP-dependent remodeling enzyme subunit BRG1 was required for T helper 2 (Th2) differentiation and Th2 cytokine transcription. BRG1 binding to cytokine genes was regulated by the extent of differentiation, the extent of activation, and cell fate. BRG1 was required for some features of the chromatin structure in target genes (DNase I hypersensitivity and histone acetylation), suggesting that BRG1 remodeling activity was directly responsible for changes in gene expression. NFAT and STAT6 activity were required for BRG1 recruitment to the Th2 locus control region, and STAT6 associated with BRG1 in a differentiation-inducible manner, suggesting direct recruitment of BRG1 to the bound loci. Together, these findings suggest BRG1 interprets differentiation signals and plays a causal role in gene regulation, chromatin structure, and cell fate.

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