Magnetic resonance imaging reveals that brain atrophy is more severe in older California sea lions with domoic acid toxicosis

Harmful Algae ◽  
2012 ◽  
Vol 20 ◽  
pp. 19-29 ◽  
Author(s):  
Eric W. Montie ◽  
Elizabeth Wheeler ◽  
Nicola Pussini ◽  
Thomas W.K. Battey ◽  
William Van Bonn ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brain Atrophy ◽  
Domoic Acid ◽  
Resonance Imaging ◽  
California Sea Lions ◽  
Sea Lions ◽  
Domoic Acid Toxicosis

Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study

2005 ◽  
Vol 11 (2) ◽  
pp. 127-134 ◽  
Author(s):  
J Versijpt ◽  
J C Debruyne ◽  
K J Van Laere ◽  
F De Vos ◽  
J Keppens ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Brain Atrophy ◽  
Microglial Activation ◽  
Grey Matter ◽  
Disease Duration ◽  
A Priori ◽  
Resonance Imaging ◽  
Normal Appearing White Matter

Objective: The objectives of the present study were to assess brain atrophy in multiple sclerosis (MS) patients during different disease stages and to investigate by PET and [11C]PK11195, a marker of microglial activation, the relationship between inflammation, atrophy and clinically relevant measures. Methods: Eight healthy subjects and 22 MS patients were included. Semiquantitative [11C]PK11195 uptake values, with normalization on cortical grey matter, were measured for magnetic resonance imaging T2- and T1-lesions and normal appearing white matter (NAWM). As atrophy index we used the ratio of the amount of white and grey matter divided by the ventricular size, using an optimized a priori based segmentation algorithm (SPM99). Results: Atrophy was significantly greater in MS patients compared to age-matched controls. A significant correlation was found between brain atrophy and both disease duration and disability, as measured with the Expanded Disability Status Scale. For NAWM, [11C]PK11195 uptake increased with the amount of atrophy, while T2-lesional [11C]PK11195 uptake values decreased according to increasing brain atrophy. Conclusions: The present study suggests that brain atrophy, correlating with disease duration and disability, is directly related to NAWM and T2-lesional inflammation as measured by microglial activation.

scholarly journals Serum profiling by MALDI-TOF mass spectrometry as a diagnostic tool for domoic acid toxicosis in California sea lions

2012 ◽  
Vol 10 (1) ◽  
pp. 18 ◽  
Author(s):  
Benjamin A Neely ◽  
Jennifer L Soper ◽  
Denise J Greig ◽  
Kevin P Carlin ◽  
Elizabeth G Favre ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Diagnostic Tool ◽  
Domoic Acid ◽  
California Sea Lions ◽  
Serum Profiling ◽  
Maldi Tof Mass Spectrometry ◽  
Sea Lions ◽  
Maldi Tof ◽  
Domoic Acid Toxicosis

Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration

PROTEOMICS ◽  
2015 ◽  
Vol 15 (23-24) ◽  
pp. 4051-4063 ◽  
Author(s):  
Benjamin A. Neely ◽  
Jennifer L. Soper ◽  
Frances M. D. Gulland ◽  
P. Darwin Bell ◽  
Mark Kindy ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Proteomic Analysis ◽  
Domoic Acid ◽  
Zalophus Californianus ◽  
California Sea Lions ◽  
Sea Lions ◽  
Domoic Acid Toxicosis
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