Integrated analysis of mRNA and miRNA expression profiles in Ptychobarbus dipogon and Schizothorax oconnori , insight into genetic mechanisms of high altitude adaptation in the schizothoracine fishes

Gene Reports ◽  
2017 ◽  
Vol 9 ◽  
pp. 74-80 ◽  
Author(s):  
Xiu Feng ◽  
Dekui He ◽  
Ge Shan ◽  
Juan Tao ◽  
Yifeng Chen
Keyword(s):  
High Altitude ◽  
Mirna Expression ◽  
Expression Profiles ◽  
Integrated Analysis ◽  
High Altitude Adaptation ◽  
Mirna Expression Profiles ◽  
Genetic Mechanisms ◽  
Altitude Adaptation ◽  
Insight Into

scholarly journals The Expression Regulatory Network in the Lung Tissue of Tibetan Pigs Provides Insight Into Hypoxia-Sensitive Pathways in High-Altitude Hypoxia

2021 ◽  
Vol 12 ◽  
Author(s):  
Yanan Yang ◽  
Haonan Yuan ◽  
Tianliang Yang ◽  
Yongqing Li ◽  
Caixia Gao ◽  
...  
Keyword(s):  
High Altitude ◽  
Regulatory Networks ◽  
Alveolar Wall ◽  
Potential Candidate ◽  
Low Oxygen ◽  
Structure Damage ◽  
High Altitude Adaptation ◽  
Tibetan Pigs ◽  
Altitude Adaptation ◽  
Insight Into

To adapt to a low-oxygen environment, Tibetan pigs have developed a series of unique characteristics and can transport oxygen more effectively; however, the regulation of the associated processes in high-altitude animals remains elusive. We performed mRNA-seq and miRNA-seq, and we constructed coexpression regulatory networks of the lung tissues of Tibetan and Landrace pigs. HBB, AGT, COL1A2, and EPHX1 were identified as major regulators of hypoxia-induced genes that regulate blood pressure and circulation, and they were enriched in pathways related to signal transduction and angiogenesis, such as HIF-1, PI3K-Akt, mTOR, and AMPK. HBB may promote the combination of hemoglobin and oxygen as well as angiogenesis for high-altitude adaptation in Tibetan pigs. The expression of MMP2 showed a similar tendency of alveolar septum thickness among the four groups. These results indicated that MMP2 activity may lead to widening of the alveolar wall and septum, alveolar structure damage, and collapse of alveolar space with remarkable fibrosis. These findings provide a perspective on hypoxia-adaptive genes in the lungs in addition to insights into potential candidate genes in Tibetan pigs for further research in the field of high-altitude adaptation.

scholarly journals Metabolic insight into mechanisms of high-altitude adaptation in Tibetans

2012 ◽  
Vol 106 (2) ◽  
pp. 244-247 ◽  
Author(s):  
Ri-Li Ge ◽  
Tatum S. Simonson ◽  
Robert C. Cooksey ◽  
Uran Tanna ◽  
Ga Qin ◽  
...  
Keyword(s):  
High Altitude ◽  
High Altitude Adaptation ◽  
Altitude Adaptation ◽  
Insight Into

scholarly journals Convergent genomic signatures of high-altitude adaptation among domestic mammals

2019 ◽  
Vol 7 (6) ◽  
pp. 952-963 ◽  
Author(s):  
Dong-Dong Wu ◽  
Cui-Ping Yang ◽  
Ming-Shan Wang ◽  
Kun-Zhe Dong ◽  
Da-Wei Yan ◽  
...  
Keyword(s):  
Positive Selection ◽  
High Altitude ◽  
Adaptive Evolution ◽  
The Tibetan Plateau ◽  
Genomic Signatures ◽  
Gene Level ◽  
Genetic Mechanisms ◽  
Altitude Adaptation ◽  
Insight Into ◽  
Molecular Convergence

Abstract Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.

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