scholarly journals Plasmodium falciparum epigenome: A distinct dynamic epigenetic regulation of gene expression

Genomics Data ◽  
2016 ◽  
Vol 7 ◽  
pp. 79-81 ◽  
Author(s):  
Mukul Rawat ◽  
Madhvi A. Bhosale ◽  
Krishanpal Karmodiya
Keyword(s):  
Gene Expression ◽  
Plasmodium Falciparum ◽  
Epigenetic Regulation ◽  
Regulation Of Gene Expression

scholarly journals Activity of Epigenetic Inhibitors against Plasmodium falciparum Asexual and Sexual Blood Stages

2020 ◽  
Vol 64 (7) ◽  
Author(s):  
Leen N. Vanheer ◽  
Hao Zhang ◽  
Gang Lin ◽  
Björn F. C. Kafsack
Keyword(s):  
Gene Expression ◽  
Plasmodium Falciparum ◽  
Epigenetic Regulation ◽  
Malaria Parasite ◽  
Regulation Of Gene Expression ◽  
Life Stages ◽  
Content Type ◽  
Promising Target ◽  
Parasite Survival ◽  
Multiple Stages

ABSTRACT Earlier genetic and inhibitor studies showed that epigenetic regulation of gene expression is critical for malaria parasite survival in multiple life stages and a promising target for new antimalarials. We therefore evaluated the activity of 350 diverse epigenetic inhibitors against multiple stages of Plasmodium falciparum. We observed ≥90% inhibition at 10 μM for 28% of compounds against asexual blood stages and early gametocytes, of which a third retained ≥90% inhibition at 1 μM.

scholarly journals Activity of epigenetic inhibitors against Plasmodium falciparum asexual and sexual blood stages

2019 ◽  
Author(s):  
Leen Vanheer ◽  
Björn F.C. Kafsack
Keyword(s):  
Gene Expression ◽  
Plasmodium Falciparum ◽  
Epigenetic Regulation ◽  
Malaria Parasite ◽  
Regulation Of Gene Expression ◽  
Life Stages ◽  
Multi Stage ◽  
Promising Target ◽  
Parasite Survival ◽  
Epigenetic Processes

AbstractRegulation of gene expression by epigenetic processes is critical for malaria parasite survival in multiple life stages. To evaluate the suitability of targeting these pathways we screened 350 epigenetic inhibitors against asexual blood stages and gametocytes of P. falciparum. We observed ≥90% inhibition at 10 µM for 28% of compounds, of which a third retained ≥90% inhibition at 1 µM. These results suggest epigenetic regulation as a promising target for the development of new multi-stage anti-malarials.

scholarly journals Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia

Leukemia ◽  
2015 ◽  
Vol 30 (6) ◽  
pp. 1436-1440 ◽  
Author(s):  
C Song ◽  
X Pan ◽  
Z Ge ◽  
C Gowda ◽  
Y Ding ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epigenetic Regulation ◽  
Regulation Of Gene Expression ◽  
Casein Kinase Ii ◽  
Casein Kinase
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