scholarly journals Dynamic Epigenetic Regulation of Gene Expression during the Life Cycle of Malaria Parasite Plasmodium falciparum

2013 ◽  
Vol 9 (2) ◽  
pp. e1003170 ◽  
Author(s):  
Archna P. Gupta ◽  
Wai Hoe Chin ◽  
Lei Zhu ◽  
Sachel Mok ◽  
Yen-Hoon Luah ◽  
...  
Keyword(s):  
Gene Expression ◽  
Plasmodium Falciparum ◽  
Life Cycle ◽  
Epigenetic Regulation ◽  
Malaria Parasite ◽  
Regulation Of Gene Expression ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum

scholarly journals Use of Peptide Nucleic Acids to Manipulate Gene Expression in the Malaria Parasite Plasmodium falciparum

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86802 ◽  
Author(s):  
Netanel Kolevzon ◽  
Abed Nasereddin ◽  
Shankar Naik ◽  
Eylon Yavin ◽  
Ron Dzikowski
Keyword(s):  
Gene Expression ◽  
Plasmodium Falciparum ◽  
Nucleic Acids ◽  
Malaria Parasite ◽  
Peptide Nucleic Acids ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum

scholarly journals Activity of Epigenetic Inhibitors against Plasmodium falciparum Asexual and Sexual Blood Stages

2020 ◽  
Vol 64 (7) ◽  
Author(s):  
Leen N. Vanheer ◽  
Hao Zhang ◽  
Gang Lin ◽  
Björn F. C. Kafsack
Keyword(s):  
Gene Expression ◽  
Plasmodium Falciparum ◽  
Epigenetic Regulation ◽  
Malaria Parasite ◽  
Regulation Of Gene Expression ◽  
Life Stages ◽  
Content Type ◽  
Promising Target ◽  
Parasite Survival ◽  
Multiple Stages

ABSTRACT Earlier genetic and inhibitor studies showed that epigenetic regulation of gene expression is critical for malaria parasite survival in multiple life stages and a promising target for new antimalarials. We therefore evaluated the activity of 350 diverse epigenetic inhibitors against multiple stages of Plasmodium falciparum. We observed ≥90% inhibition at 10 μM for 28% of compounds against asexual blood stages and early gametocytes, of which a third retained ≥90% inhibition at 1 μM.

scholarly journals Activity of epigenetic inhibitors against Plasmodium falciparum asexual and sexual blood stages

2019 ◽  
Author(s):  
Leen Vanheer ◽  
Björn F.C. Kafsack
Keyword(s):  
Gene Expression ◽  
Plasmodium Falciparum ◽  
Epigenetic Regulation ◽  
Malaria Parasite ◽  
Regulation Of Gene Expression ◽  
Life Stages ◽  
Multi Stage ◽  
Promising Target ◽  
Parasite Survival ◽  
Epigenetic Processes

AbstractRegulation of gene expression by epigenetic processes is critical for malaria parasite survival in multiple life stages. To evaluate the suitability of targeting these pathways we screened 350 epigenetic inhibitors against asexual blood stages and gametocytes of P. falciparum. We observed ≥90% inhibition at 10 µM for 28% of compounds, of which a third retained ≥90% inhibition at 1 µM. These results suggest epigenetic regulation as a promising target for the development of new multi-stage anti-malarials.

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