scholarly journals Repeated intracerebral hemorrhage as a presentation of pulmonary giant cell carcinoma with brain metastases

2014 ◽  
Vol 47 (4) ◽  
pp. 145-149
Author(s):  
Dong-Syuan Wu ◽  
Chieh-Hsin Wu ◽  
Shiuh-Lin Hwang ◽  
Joon-Khim Loh
Keyword(s):  
Brain Metastases ◽  
Intracerebral Hemorrhage ◽  
Cell Carcinoma ◽  
Giant Cell ◽  
Giant Cell Carcinoma

scholarly journals Pleomorphic Giant Cell Carcinoma of Urinary Bladder with Brain Metastases Despite Initial Response to Cisplatin and Gemcitabine: A Case Report

2020 ◽  
Vol 4 (3) ◽  
pp. 46-50
Author(s):  
Antonio Vega Vega ◽  
◽  
Fraser Simpson ◽  
Hemali Samaratunga ◽  
Antonio J. Vega-Garcia ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Brain Metastases ◽  
Cell Carcinoma ◽  
Giant Cell ◽  
Primary Tumour ◽  
Initial Response ◽  
Giant Cell Carcinoma ◽  
Carcinoma Of The Bladder ◽  
Pleomorphic Giant Cell Carcinoma

A 59-year-old male presented with haematuria and was diagnosed with pleomorphic giant cell carcinoma of the urinary bladder, a very rare variant of urothelial carcinoma. The tumour was staged at pT2N3M1 and the primary tumour was removed by transurethral resection, and nodal metastases were treated with the standard systemic cisplatin and gemcitabine for urothelial cell carcinoma of the bladder. This treatment rendered the tumour clinically undetectable. Despite this treatment the patient developed brain metastases which were not found until the patient presented with neurological symptoms. This is the first recorded case of brain metastases from pleomorphic giant cell carcinoma of the urinary bladder recorded in the literature. CT imaging of the brain should be considered in the follow-up in patients with this tumour.

scholarly journals Nonsmall Cell Lung Carcinoma with Giant Cell Features Expressing Programmed Death-Ligand 1: A Report of a Patient Successfully Treated with Pembrolizumab

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Shingo Nakayama ◽  
Mamoru Sasaki ◽  
Shojiroh Morinaga ◽  
Naoto Minematsu
Keyword(s):  
Brain Metastases ◽  
Cell Carcinoma ◽  
Giant Cell ◽  
Tumor Cells ◽  
Lung Carcinoma ◽  
Cell Lung Carcinoma ◽  
Programmed Death Ligand 1 ◽  
Giant Cell Carcinoma ◽  
Nonsmall Cell Lung Carcinoma ◽  
Programmed Death

Giant cell carcinoma, a rare variant of nonsmall cell lung carcinoma (NSCLC), is characterized by aggressive progression and poor response to conventional chemotherapy. This report is the first to describe a patient with NSCLC and giant cell features who was successfully treated with pembrolizumab, an antibody targeting programmed death-1 (PD-1). A 69-year-old woman was diagnosed with NSCLC with multiple brain metastases. Histological evaluation of lung biopsy specimens revealed proliferation of pleomorphic giant tumor cells with poor cohesiveness, findings consistent with giant cell carcinoma. Immunostaining showed that a high proportion of the tumor cells were positive for expression of programmed death-ligand 1 (PD-L1). The patient received stereotactic radiotherapy for the brain metastases, followed by administration of pembrolizumab. Treatment with pembrolizumab resulted in the rapid regression of the primary lung nodule, with the progression-free period maintained for at least four treatment cycles. Immunotherapy targeting PD-1/PD-L1 may be an option for patients with PD-L1-positive NSCLC with giant cell features.

An autopsy case of pulmonary giant cell carcinoma

Haigan ◽  
1979 ◽  
Vol 19 (3) ◽  
pp. 277-284
Author(s):  
Yosei Katayama ◽  
Tetsuo Ueno ◽  
Koshi Maruyama ◽  
Kinya Sawada ◽  
Yasuo Seki
Keyword(s):  
Cell Carcinoma ◽  
Giant Cell ◽  
Autopsy Case ◽  
Giant Cell Carcinoma

Pleomorphic giant cell carcinoma of prostate: Rare tumor with unique clinicopathological, immunohistochemical, and molecular features

2021 ◽  
Vol 52 ◽  
pp. 151719
Author(s):  
Ziad M. El-Zaatari ◽  
Jessica S. Thomas ◽  
Mukul K. Divatia ◽  
Steven S. Shen ◽  
Alberto G. Ayala ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Giant Cell ◽  
Rare Tumor ◽  
Giant Cell Carcinoma ◽  
Molecular Features ◽  
Pleomorphic Giant Cell Carcinoma

ULTRASTRUCTURE OF AN ANAPLASTIC GIANT-CELL CARCINOMA FOUND 8 YEARS AFTER OPERATION ON A PAPILLARY CARCINOMA OF THE THYROID

1978 ◽  
Vol 28 (4) ◽  
pp. 637-644
Author(s):  
Yoshio Hiasa ◽  
Noriyuki Ito ◽  
Masato Ohshima ◽  
Tomoyoshi Ohmori ◽  
Asao Seki ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Giant Cell ◽  
Papillary Carcinoma ◽  
Giant Cell Carcinoma

Orofacial metastasis of pulmonary giant cell carcinoma

1991 ◽  
Vol 71 (1) ◽  
pp. 80-83 ◽  
Author(s):  
Gloria G. Vaughan ◽  
Valerie A. Murrah ◽  
Michael T. Montgomery
Keyword(s):  
Cell Carcinoma ◽  
Giant Cell ◽  
Giant Cell Carcinoma

scholarly journals UNUSUAL PRESENTATION OF GIANT CELL CARCINOMA OF THE LUNG

1999 ◽  
Vol 55 (3) ◽  
pp. 267-269
Author(s):  
KAILASH CHAND ◽  
SC TEWARI ◽  
SJ VARGHESE
Keyword(s):  
Cell Carcinoma ◽  
Giant Cell ◽  
Unusual Presentation ◽  
Giant Cell Carcinoma
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