scholarly journals Biochemical engineering of theN-acyl side chain of sialic acids alters the kinetics of a glycosylated potassium channel Kv3.1

FEBS Letters ◽  
2011 ◽  
Vol 585 (20) ◽  
pp. 3322-3327 ◽  
Author(s):  
M. Kristen Hall ◽  
Werner Reutter ◽  
Thisbe Lindhorst ◽  
Ruth A. Schwalbe
2002 ◽  
Vol 80 (10) ◽  
pp. 671-677 ◽  
Author(s):  
Pablo Villavicencio-Lorini ◽  
Stephan Laabs ◽  
Kerstin Danker ◽  
Werner Reutter ◽  
Rüdiger Horstkorte

1998 ◽  
Vol 253 (2) ◽  
pp. 437-442 ◽  
Author(s):  
Oliver T. Keppler ◽  
Markus Herrmann ◽  
Claus W. von der Lieth ◽  
Peer Stehling ◽  
Werner Reutter ◽  
...  

Glycobiology ◽  
2001 ◽  
Vol 11 (2) ◽  
pp. 11R-18R ◽  
Author(s):  
O. T. Keppler ◽  
R. Horstkorte ◽  
M. Pawlita ◽  
C. Schmidt ◽  
W. Reutter

FEBS Letters ◽  
1996 ◽  
Vol 395 (2-3) ◽  
pp. 170-173 ◽  
Author(s):  
J.Raimund Wieser ◽  
Anja Heisner ◽  
Peer Stehling ◽  
Franz Oesch ◽  
Werner Reutter

2012 ◽  
Vol 195 (3) ◽  
pp. 585-595 ◽  
Author(s):  
J. Holert ◽  
Z. Kulic ◽  
O. Yucel ◽  
V. Suvekbala ◽  
M. J.- F. Suter ◽  
...  

1980 ◽  
Vol 1 (7) ◽  
pp. 197-201
Author(s):  
Michael J. Kraemer ◽  
Arnold L. Smith

Ampicillin, first introduced in 1961, has probably become the most widely used penicillin in clinical pediatrics. STRUCTURE ACTIVITY RELATIONSHIPS All penicillins contain the 6-amino penicillanic acid moiety (Fig 1). Its structure includes a thiazolidine ring (A), a β-lactam ring (B), the source of antibacterial activity, and an acyl side chain (R), containing a variety of substitutions creating the family of semisynthetic penicillins. The only difference between ampicillin and penicillin G is the presence of an amino group in the acyl side chain (Fig 1). PHARMACOLOGY AND BACTERIOLOGY Ampicillin is a semisynthetic penicillin, active against Streptococus pneumoniae and certain Gram-negative bacteria, including most Haemophilus influenzae, Escherichia coli, and certain Proteus species. Compared to penicillin G, it has increased stability in acid solutions: a property facilitating oral administration and absorption. It penetrates into most body tissues; effective entry into CSF, however, occurs only with inflamed meninges. The serum half-life with normal renal function varies from four hours in newborns1 to 1.3 hours in adults.2 Ampicillin can cause an allergic, or nonallergic skin rash (Fig 2). ALLERGY Allergy (for the purposes of this discussion) is defined as a specific immunologic interaction, between either antigen and antibody, or antigen with a sensitized lymphocyte, resulting in a clinically deleterious effect. Implicit is a prior contact with the antigen.


2017 ◽  
Vol 112 (3) ◽  
pp. 172a-173a
Author(s):  
Laura S. Alberio ◽  
Giordano Defranceschi ◽  
Federica Simeoni ◽  
Paolo Zuccolini ◽  
Gerhard Thiel ◽  
...  

2005 ◽  
Vol 38 (7) ◽  
pp. 2729-2738 ◽  
Author(s):  
Mikhail Kozlovsky ◽  
Berndt-J. Jungnickel ◽  
Helmut Ehrenberg

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