scholarly journals Capsaicin induced histological and ultrastructural changes in the submandibular salivary gland of albino rats

2016 ◽  
Vol 2 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Ahmed Mahmoud Halawa ◽  
Dahlia Ghazy Mohamed ◽  
Raneem Farouk Mohamed Adeeb Obeid
Keyword(s):  
Salivary Gland ◽  
Ultrastructural Changes ◽  
Albino Rats ◽  
Submandibular Salivary Gland

scholarly journals Effect of Sofosbuvir Administration and Its Withdrawal on the Submandibular Salivary Gland of Adult Male Albino Rats: A Histological and Ultra-Structural Study

2019 ◽  
Vol 7 (23) ◽  
pp. 4101-4109
Author(s):  
Asmaa Mahmoud Abdeen ◽  
Tarik Essawy ◽  
Saher Sayed Mohammed
Keyword(s):  
Salivary Gland ◽  
Inflammatory Cells ◽  
Control Group ◽  
Albino Rats ◽  
Submandibular Salivary Gland ◽  
Distilled Water ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Histological Results

BACKGROUND: Sofosbuvir (SOF) was published in 2013 as a part of first-line treatments for hepatitis C virus (HCV); it has activity against all genotypes with extrahepatic adverse effects have recently arisen. AIM: Investigating sofosbuvir-induced alterations in the rat submandibular salivary gland (SMSG). METHODS: A group of 80 adult albino rats weighing about ± 150 gm were used in the experiment. The rats were divided into 3 groups: Group I (control group) received distilled water, Group II (experimental group) divided into 2 subgroups and received SOF 40 mg/kg/day dissolved in distilled water for 1 and 3 months and Group III (recovery group) allowed for 1 month of recovery after SOF withdrawal. All animals were sacrificed; the SMSG was dissected, and specimens were examined histologically and ultra-structurally. RESULTS: Compared to Group I, Group II subgroup (1) showed acinar and ductal vacuolisation, discontinuity of the epithelial lining associated with retained secretion and congested blood vessels. These changes were found to be exaggerated in the subgroup (2) accompanied by acinar and ductal shrinkage, interstitial oedema, haemorrhage, chronic inflammatory cells infiltration and loss of gland compactness. Amelioration of the histological changes was detected in Group III after SOF withdrawal. The ultrastructural examination confirmed the histological results. CONCLUSION: SOF had induced apparent alterations in the structure and ultrastructure of SMSG. The SOF-induced alterations were time-dependent, attributed mainly to mitochondrial toxicity and partially ameliorated by its withdrawal.  

scholarly journals УЛЬТРАМІКРОСКОПІЧНІ ПРОЯВИ У СТРУКТУРІ ПІДНИЖНЬОЩЕЛЕПНОЇ СЛИННОЇ ЗАЛОЗИ НАПРИКІНЦІ 2-ГО ТИЖНЯ ЕКСПЕРИМЕНТАЛЬНОГО ОПІОЇДНОГО ВПЛИВУ

World Science ◽  
2020 ◽  
Vol 1 (4(56)) ◽  
pp. 4-7
Author(s):  
Mykhalevych Marta
Keyword(s):  
Endothelial Cells ◽  
Endoplasmic Reticulum ◽  
Salivary Gland ◽  
Connective Tissue ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Acinar Cells ◽  
Ultrastructural Changes ◽  
Submandibular Salivary Gland ◽  
Perivascular Edema

This publication demonstrates the ultrastructural changes of the submandibular salivary gland under the opioid effect at the 2nd week of the experimental research.After 14 days of experimental opioid effect, we found the destructive changes in the organelles of exocrinocytes of acinar cells, as well as dyscirculatory processes. Capillary lumen was enlarged, overflowing with red blood cells. In the endothelium of the capillaries also noted the expansion of the granular endoplasmic reticulum. Small vacuoles appeared in the cytoplasm of endothelial cells. Single mitochondria located in the area of the endothelial cytoplasmic organelles are swollen. Due to the development of perivascular edema, the underlying connective tissue substance around the capillaries was impregnated with electron-illuminated transudate masses.

scholarly journals УЛЬТРАМІКРОСКОПІЧНІ ПРОЯВИ У СТРУКТУРІ ПІДНИЖНЬОЩЕЛЕПНОЇ СЛИННОЇ ЗАЛОЗИ НАПРИКІНЦІ 4-ГО ТИЖНЯ ЕКСПЕРИМЕНТАЛЬНОГО ОПІОЇДНОГО ВПЛИВУ

2020 ◽  
pp. 3-6
Author(s):  
Mykhalevych Marta
Keyword(s):  
Endoplasmic Reticulum ◽  
Salivary Gland ◽  
Experimental Research ◽  
Smooth Endoplasmic Reticulum ◽  
Secretory Granules ◽  
Acinar Cells ◽  
Secretory Protein ◽  
Ultrastructural Changes ◽  
Submandibular Salivary Gland ◽  
Apical Area

This publication demonstrates the ultrastructural changes of the submandibular salivary gland under the opioid effect at the 4th week of the experimental research. After 28 days of experimental opioid effect, we found that in exocrinocytes of the end secretory departments of acinar cells revealed the destruction of organelles, especially granular and smooth endoplasmic reticulum, mitochondria, as well as reducing the content of secretory granules in the apical area of glandulocytes. In some exocrinocytes, as a result of the increase in destructive changes, a decrease in the volume of the nucleus was noted, which moved to the peripheral parts of the cell. Necrotic changes developed in individual exocrinocytes of the final secretory protein divisions. In such cells, the nucleus was reduced in volume, filled with heterochromatin.

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