scholarly journals IMPACT OF BONE MARROW STEM CELLS APPLICATION ON THE METHOTREXATE INDUCED SUBMANDIBULAR SALIVARY GLAND DEGENERATIVE CHANGES IN ALBINO RATS (HISTOLOGICAL AND IMMUNO-HISTOCHEMICAL STUDY)

2019 ◽  
Vol 65 (2) ◽  
pp. 1751-1762
Author(s):  
Heba El Emam ◽  
Nesreen Abd El Salam ◽  
Shaimaa Ghazy
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Salivary Gland ◽  
Histochemical Study ◽  
Bone Marrow Stem Cells ◽  
Degenerative Changes ◽  
Albino Rats ◽  
Submandibular Salivary Gland

Exosomes Derived from Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSC) Protect Submandibular Glands in Diabetic Rats

2021 ◽  
Vol 11 (11) ◽  
pp. 2168-2173
Author(s):  
Cong Zhang ◽  
Xiaohong Zhang ◽  
Min Zhang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Salivary Gland ◽  
Salivary Glands ◽  
Serum Amylase ◽  
Diabetic Rats ◽  
Submandibular Salivary Gland ◽  
Amylase Level ◽  
Group I

Our study assess whether exosomes derived from bone marrow mesenchymal stem cells (BM-MSC) ameliorates diabetic salivary gland complications. 10 SD rats were assigned into diabetes group I and exosome treatment group II. Diabetic rats were induced by streptozotocin (STZ) and injected with DMSO or exosomes through tail vein followed by collection of submandibular salivary gland samples for histological analysis and TGFβ, Smad2 and Smad3 level by PCR, saliva IgA and serum amylase level. Compared with control mice, exosome treatment mice showed less fibrosis of the submandibular salivary glands and duct components with a more complete structure. Exosome treatment inhibited TGFβ, Smad2 and Smad3 level to reduce diabetic salivary gland complications, effectively decreased blood sugar level, improved salivary glands function with significantly reduced serum amylase and salivary IgA levels. In conclusion, BM-MSC-derived exosomes may be a new therapeutic strategy for treating diabetic salivary gland complications.

scholarly journals Effect of mesenchymal stem cells on cytochrome-c release and inflammation in colon cancer induced by 1,2-dimethylhydrazine in Wistar albino rats

2021 ◽  
Vol 41 (3) ◽  
Author(s):  
Afrah F. Alkhuriji ◽  
Seham G. Alsaiari ◽  
Suliman Y. Alomar ◽  
Alaa A. Alnafjan ◽  
Hussah Alobaid ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Colon Cancer ◽  
Mesenchymal Stem Cells ◽  
Inflammatory Cells ◽  
Redox Status ◽  
Bone Marrow Stem Cells ◽  
Albino Rats ◽  
Cytochrome C Release ◽  
Antitumor Effects

Abstract Colon cancer is one of the most common causes of deaths by cancer worldwide. Stem cells have immunosuppressive properties that promote tumor targeting and circumvent obstacles currently in gene therapy. Bone marrow stem cells are believed to have anticancer potential. The transplantation of mesenchymal stem cells (MSCs), a type of bone marrow stem cells, has been considered a potential therapy for patients with solid tumors due to their capability to enhance the immune response; MSC transplantation has received renewed interest in recent years. The present study aimed to evaluate the antiapoptotic effects of the MSCs on 1,2-dimethylhydrazine (DMH)-induced inflammation in the rat model of colorectal cancer. The rats were randomly allocated into four groups: control, treated with MSCs, induced by DMH, and induced by DMH and treated with MSCs. The MSCs were intra-rectally injected, and DMH was subcutaneously injected at 20 mg/kg body weight once a week for 15 weeks. The administration of MSCs into rats starting from day 0 of the DMH injection was found to enhance the histopathological picture. The MSC treatment resulted in fewer inflammatory cells than in the DMH group. Therefore, our findings suggest that BMCs have antitumor effects by modulating the cellular redox status and down-regulating the pro-inflammatory genes. Thus, BMCs may provide therapeutic value for colon cancer treatment.

scholarly journals The Effect of In Vivo Mobilization of Bone Marrow Stem Cells on the Pancreas of Diabetic Albino Rats (A Histological & Immunohistochemical Study)

2013 ◽  
Vol 6 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Zeinab Mohamed Kamel Ismail ◽  
Ashraf Mahmoud Fawzy Kamel ◽  
Mira Farouk Youssef Yacoub ◽  
Alshaymaa Gamal Aboulkhair
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Immunohistochemical Study ◽  
Bone Marrow Stem Cells ◽  
Albino Rats

Bone marrow stem cells make hepatocytes with replicative potential

2001 ◽  
Vol 120 (5) ◽  
pp. A62-A62
Author(s):  
S FORBES ◽  
M ALISON ◽  
K HODIVALADILKE ◽  
R JEFFERY ◽  
R POULSOM ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Bone Marrow Stem Cells

Autologous 5-azacytidine-cultured bone-marrow stem cells in surgical treatment of heart failure

2008 ◽  
Vol 7 ◽  
pp. 114-115
Author(s):  
R AKCHURIN ◽  
T RAKHMATZADE ◽  
E SKRIDLEVSKAYA ◽  
L SAMOYLENKO ◽  
V SERGIENKO ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cells ◽  
Bone Marrow ◽  
Surgical Treatment ◽  
Bone Marrow Stem Cells
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