In vivo toxicity studies of fusarium mycotoxins in the last decade: A review

2015 ◽  
Vol 78 ◽  
pp. 185-206 ◽  
Author(s):  
L. Escrivá ◽  
G. Font ◽  
L. Manyes
Keyword(s):  
Fusarium Mycotoxins ◽  
In Vivo Toxicity ◽  
Toxicity Studies

In Vivo Toxicity Studies of Chitosan-Coated Cobalt Ferrite Nanocomplex for Its Application as MRI Contrast Dye

2020 ◽  
Vol 3 (11) ◽  
pp. 7952-7964
Author(s):  
Md. Salman Shakil ◽  
Md. Ashraful Hasan ◽  
Md. Forhad Uddin ◽  
Aminul Islam ◽  
Arijun Nahar ◽  
...  
Keyword(s):  
Cobalt Ferrite ◽  
Mri Contrast ◽  
In Vivo Toxicity ◽  
Toxicity Studies

scholarly journals Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies

2019 ◽  
Vol 70 (6) ◽  
pp. 1903-1907
Author(s):  
Roxana Liana Stan ◽  
Bogdan Sevastre ◽  
Adriana Corina Hangan ◽  
Sanda Bota ◽  
Daniela Hanganu ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Artemisia Annua ◽  
Histopathological Examination ◽  
Haematological Toxicity ◽  
Chemical Characterization ◽  
In Vivo Toxicity ◽  
Artemisia Annua L ◽  
Toxicity Studies

The purpose of the study was to demonstrate in vitro antioxidant activity and in vivo toxicity of the Artemisia Annua L. extract. The plant was harvested from Bihor area (Crisul Repede and Negru river valleys), Romania. Preparation of the plant product and of the lyophilizated extract was carried out in accordance with the Romanian Pharmacopeia Xth Edition. Lyophilized extract was evaluated in terms of polyphenol content using HPLC method. Antioxidant activity was highlighted using the DPPH, ABTS and FRAP methods. Hepatic, renal and haematological toxicity studies have been performed on laboratory mice. For this purpose blood and organs were collected. Biochemical and haematological parameters were determined on the blood samples and histopathological examination was performed on organs. In vitro antioxidant effect of Artemisia Annua L extract and its lack of in vivo toxicity were demonstrated. It is desirable to obtain a new phytoproduct harvested from spontaneous flora of Romania with antioxidant / antitumoral properties and which is devoid of toxicity.

In vitro and in vivo toxicity studies of copper sulfide nanoplates for potential photothermal applications

2015 ◽  
Vol 11 (4) ◽  
pp. 901-912 ◽  
Author(s):  
Wei Feng ◽  
Wei Nie ◽  
Yanhua Cheng ◽  
Xiaojun Zhou ◽  
Liang Chen ◽  
...  
Keyword(s):  
Copper Sulfide ◽  
In Vivo Toxicity ◽  
Toxicity Studies

Biologically Synthesized Plant-Derived Nanomedicines and Their In vitro-- In vivo Toxicity Studies in Various Cancer Therapeutics: Regulatory Perspectives

2021 ◽  
pp. 217-260
Author(s):  
Mohamed Sheik Tharik Abdul Azeeze ◽  
Santhosh Shanthi Bhupathi ◽  
Elmutaz Belah Mohammad ◽  
Durairaj Kaliannan ◽  
Balamuralikrishnan Balasubramanian ◽  
...  
Keyword(s):  
Cancer Therapeutics ◽  
In Vivo Toxicity ◽  
Toxicity Studies

In Vivo Toxicity Profile of NN-32 and Nanogold Conjugated GNP-NN-32 from Indian Spectacled Cobra Venom

2020 ◽  
Vol 21 (14) ◽  
pp. 1479-1488
Author(s):  
Saurabh S. Attarde ◽  
Sangeeta V. Pandit
Keyword(s):  
Chronic Toxicity ◽  
Significant Inhibition ◽  
Toxicity Profile ◽  
Naja Naja ◽  
In Vivo Toxicity ◽  
Toxicity Studies ◽  
Serum Biochemical ◽  
Reduced Toxicity

Background: NN-32 toxin, which was obtained from Naja naja venom and showed cytotoxicity on cancer cell lines. As the toxicity of NN-32 is the main hurdle in the process of drug development; hence, we have conjugated NN-32 toxin with gold nanoparticles (GNP-NN-32) in order to decrease the toxicity of NN-32 without reducing its efficacy, GNP-NN-32 alleviated the toxicity of NN-32 in in vitro studies during the course of earlier studies. In continuation, we are evaluating in vivo toxicity profile of NN-32 and GNP-NN-32 in the present study. Objective: To study in vivo toxicity profile of NN-32 and nanogold conjugated GNP-NN-32 from Naja naja venom. Materials and Methods: We have carried out in vivo acute toxicity study to determine LD50 dose of GNP-NN-32, in vivo sub-chronic toxicity for 30 days, haematology, serum biochemical parameters and histopathology study on various mice tissues and in vitro cellular and tissue toxicity studies. Results: The LD50 dose of GNP-NN-32 was found to be 2.58 mg/kg (i.p.) in Swiss male albino mice. In vivo sub-chronic toxicity showed significantly reduced toxicity of GNP-NN-32 as compared to NN-32 alone. Discussion: In vitro cellular toxicity studies on human lymphocyte and mouse peritoneal macrophage showed significant inhibition of cells by NN-32 alone. Conclusion: Conjugated GNP-NN-32 toxin showed less in vivo toxicity as compared to pure NN-32.

In vivo toxicity studies of nanoparticles

2008 ◽  
Vol 180 ◽  
pp. S222 ◽  
Author(s):  
Alexander Nikitin ◽  
Yi Wang ◽  
Emmanuel Giannelis
Keyword(s):  
In Vivo Toxicity ◽  
Toxicity Studies
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