Maternal nicotine exposure leads to higher liver oxidative stress and steatosis in adult rat offspring

2015 ◽  
Vol 78 ◽  
pp. 52-59 ◽  
Author(s):  
E.P. Conceição ◽  
N. Peixoto-Silva ◽  
C.R. Pinheiro ◽  
E. Oliveira ◽  
E.G. Moura ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nicotine Exposure ◽  
Adult Rat ◽  
Rat Offspring

scholarly journals Intravenous gestational nicotine exposure results in increased motivation for sucrose reward in adult rat offspring

2012 ◽  
Vol 124 (3) ◽  
pp. 299-306 ◽  
Author(s):  
Ryan T. Lacy ◽  
Lauren L. Hord ◽  
Amanda J. Morgan ◽  
Steven B. Harrod
Keyword(s):  
Nicotine Exposure ◽  
Sucrose Reward ◽  
Adult Rat ◽  
Rat Offspring ◽  
Gestational Nicotine

Maternal nicotine exposure during lactation alters food preference, anxiety-like behavior and the brain dopaminergic reward system in the adult rat offspring

2015 ◽  
Vol 149 ◽  
pp. 131-141 ◽  
Author(s):  
C.R. Pinheiro ◽  
E.G. Moura ◽  
A.C. Manhães ◽  
M.C. Fraga ◽  
S. Claudio-Neto ◽  
...  
Keyword(s):  
Food Preference ◽  
Reward System ◽  
Nicotine Exposure ◽  
Adult Rat ◽  
Rat Offspring ◽  
The Brain

Intrauterine ethanol exposure results in hypothalamic oxidative stress and neuroendocrine alterations in adult rat offspring

2006 ◽  
Vol 291 (3) ◽  
pp. R796-R802 ◽  
Author(s):  
Korami Dembele ◽  
Xing-Hai Yao ◽  
Li Chen ◽  
B. L. Grégoire Nyomba
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Neuropeptide Y ◽  
Adult Life ◽  
Female Rats ◽  
Protein Carbonyls ◽  
Adult Offspring ◽  
Mrna Levels ◽  
Adult Rat ◽  
Rat Offspring

Prenatal ethanol (EtOH) exposure is associated with low birth weight, followed by increased appetite, catch-up growth, insulin resistance, and impaired glucose tolerance in the rat offspring. Because EtOH can induce oxidative stress, which is a putative mechanism of insulin resistance, and because of the central role of the hypothalamus in the regulation of energy homeostasis and insulin action, we investigated whether prenatal EtOH exposure causes oxidative damage to the hypothalamus, which may alter its function. Female rats were given EtOH by gavage throughout pregnancy. At birth, their offspring were smaller than those of non-EtOH rats. Markers of oxidative stress and expression of neuropeptide Y and proopiomelanocortin (POMC) were determined in hypothalami of postnatal day 7 (PD7) and 3-mo-old (adult) rat offspring. In both PD7 and adult rats, prenatal EtOH exposure was associated with decreased levels of glutathione and increased expression of MnSOD. The concentrations of lipid peroxides and protein carbonyls were normal in PD7 EtOH-exposed offspring, but were increased in adult EtOH-exposed offspring. Both PD7 and adult EtOH-exposed offspring had normal neuropeptide Y and POMC mRNA levels, but the adult offspring had reduced POMC protein concentration. Thus only adult offspring preexposed to EtOH had increased hypothalamic tissue damage and decreased levels of POMC, which could impair melanocortin signaling. We conclude that prenatal EtOH exposure causes hypothalamic oxidative stress, which persists into adult life and alters melanocortin action during adulthood. These neuroendocrine alterations may explain weight gain and insulin resistance in rats exposed to EtOH early in life.

scholarly journals Maternal Undernutrition Significantly Impacts Ovarian Follicle Number and Increases Ovarian Oxidative Stress in Adult Rat Offspring

PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e15558 ◽  
Author(s):  
Angelica B. Bernal ◽  
Mark H. Vickers ◽  
Mark B. Hampton ◽  
Rebecca A. Poynton ◽  
Deborah M. Sloboda
Keyword(s):  
Oxidative Stress ◽  
Ovarian Follicle ◽  
Adult Rat ◽  
Maternal Undernutrition ◽  
Rat Offspring

scholarly journals Selenium nanoparticles mitigate diabetic nephropathy and pancreatopathy in rat offspring via inhibition of oxidative stress

2021 ◽  
Vol 33 (1) ◽  
pp. 101265
Author(s):  
Iftekhar Hassan ◽  
Hossam Ebaid ◽  
Jameel Al-Tamimi ◽  
Mohamed A. Habila ◽  
Ibrahim M. Alhazza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Nephropathy ◽  
Selenium Nanoparticles ◽  
Rat Offspring

Breastfeeding undernutrition changes iBAT-involved thermogenesis protein expression and leads to a lean phenotype in adult rat offspring

2021 ◽  
pp. 108857
Author(s):  
Ginislene Dias Souza Miranda ◽  
Thalyne Aparecida Leite de Lima ◽  
Hercules de Oliveira Costermani ◽  
Camila Luiza Rodrigues dos Santos Ricken ◽  
Jocemara Patrícia Silva de Souza Parrela ◽  
...  
Keyword(s):  
Protein Expression ◽  
Adult Rat ◽  
Rat Offspring

The effects of prenatal “psychological” stressor exposure on lung inflammation and hyperresponsiveness in adult rat offspring

2016 ◽  
Vol 58 (8) ◽  
pp. 1076-1086 ◽  
Author(s):  
Maria Beatriz Barreto do Carmo ◽  
Renato Fraga Righetti ◽  
Iolanda de Fátima Lopes Calvo Tibério ◽  
Maria Helena Leite Hunziker
Keyword(s):  
Lung Inflammation ◽  
Adult Rat ◽  
Rat Offspring ◽  
Psychological Stressor
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