Medium optimization and potential hepatoprotective effect of mycelial polysaccharides from Pholiota dinghuensis Bi against carbon tetrachloride-induced acute liver injury in mice

2012 ◽  
Vol 50 (8) ◽  
pp. 2681-2688 ◽  
Author(s):  
Dan Gan ◽  
Liping Ma ◽  
Changxing Jiang ◽  
Mingchun Wang ◽  
Xiaoxiong Zeng
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Medium Optimization ◽  
Acute Liver Injury ◽  
Hepatoprotective Effect

Hepatoprotective Effect of Scoparia dulcis on Carbon Tetrachloride Induced Acute Liver Injury in Mice

2010 ◽  
Vol 38 (04) ◽  
pp. 761-775 ◽  
Author(s):  
Jen-Chieh Tsai ◽  
Wen-Huang Peng ◽  
Tai-Hui Chiu ◽  
Shun-Chieh Huang ◽  
Tai-Hung Huang ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
High Performance ◽  
Acute Liver Injury ◽  
Ethanol Extract ◽  
Significant Inhibition ◽  
Hepatoprotective Effect ◽  
Oxidative Enzymes ◽  
Active Constituents ◽  
Scoparia Dulcis

This study aims to investigate the hepatoprotective activity and active constituents of the ethanol extract of Scoparia dulcis (SDE). The hepatoprotective effect of SDE (0.1, 0.5 and 1 g/kg) was evaluated on the carbon tetrachloride ( CCl4 )-induced acute liver injury. The active constituents were detected by high performance liquid chromatography (HPLC). Mice pretreated orally with SDE (0.5 and 1.0 g/kg) and silymarin (200 mg/kg) for five consecutive days before the administering of a single dose of 0.2% CCl4 (10 ml/kg of bw, ip) showed a significant inhibition of the increase of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Histological analyses also showed that SDE (0.5 and 1.0 g/kg) and silymarin reduced the extent of liver lesions induced by CCl4 , including vacuole formation, neutrophil infiltration and necrosis. Moreover, SDE decreased the malondialdehyde (MDA) level and elevated the content of reduced glutathione (GSH) in the liver as compared to those in the CCl4 group. Furthermore, SDE (0.5 and 1.0 g/kg) enhanced the activities of anti-oxidative enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd) and glutathione-S-transferase (GST). The quantities of active constituents in SDE were about 3.1 mg luteolin/g extract and 1.1 mg apigenin/g extract. The hepatoprotective mechanisms of SDE were likely associated to the decrease in MDA level and increase in GSH level by increasing the activities of antioxidant enzymes such as SOD, GPx, GRd and GST. These results demonstrated that SDE could alleviate CCl4 -induced acute liver injury in mice.

Hepatoprotective effect of orally applied water-soluble pristine C60 fullerene against CCl4-induced acute liver injury in rats

RSC Advances ◽  
2016 ◽  
Vol 6 (102) ◽  
pp. 100046-100055 ◽  
Author(s):  
T. I. Halenova ◽  
I. M. Vareniuk ◽  
N. M. Roslova ◽  
M. E. Dzerzhynsky ◽  
O. M. Savchuk ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Oral Administration ◽  
Small Dose ◽  
Acute Liver Injury ◽  
Water Soluble ◽  
Hepatoprotective Effect ◽  
C60 Fullerene ◽  
Applied Water

Oral administration of water-soluble pristine C60 fullerene in small dose prevents acute liver injury caused by carbon tetrachloride in rats.

scholarly journals Hepatoprotective effect of the ethanol extract of Polygonum orientale on carbon tetrachloride-induced acute liver injury in mice

2018 ◽  
Vol 26 (1) ◽  
pp. 369-379 ◽  
Author(s):  
Yung-Jia Chiu ◽  
Shen-Chieh Chou ◽  
Chuan-Sung Chiu ◽  
Chun-Pin Kao ◽  
Kun-Chang Wu ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Ethanol Extract ◽  
Hepatoprotective Effect

Hepatoprotective Effect ofShidagonglaoon Acute Liver Injury Induced by Carbon Tetrachloride

2009 ◽  
Vol 37 (06) ◽  
pp. 1085-1097 ◽  
Author(s):  
Jung Chao ◽  
Meng-Shiou Lee ◽  
Sakae Amagaya ◽  
Jiunn-Wang Liao ◽  
Jin-Bin Wu ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Ethanol Extract ◽  
Neutrophil Infiltration ◽  
Treated Group ◽  
Hepatoprotective Activity ◽  
Hepatoprotective Effect ◽  
Oxidative Enzymes ◽  
Tnf Α

This study investigates the hepatoprotective activity of ethanol extract from Shidagonglao roots (SDGLEtOH). The hepatoprotective effect of SDGLEtOH(20, 100 and 500 mg/kg) was analyzed on carbon tetrachloride ( CCl4)-induced acute liver injury. Rats pretreated orally with SDGLEtOH(100 and 500 mg/kg) and silymarin (200 mg/kg) for 3 consecutive days prior to the administration of a single dose of 50% CCl4(0.10 ml/100 g of bw, ip) significantly prevented the increases in the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in CCl4-treated rats. Histological analysis also showed that SDGLEtOH(100 and 500 mg/kg) and silymarin reduced the incidence of liver lesions including vacuole formation, neutrophil infiltration and necrosis of hepatocytes induced by CCl4in rats. Moreover, the SDGLEtOH(100 and 500 mg/kg) increased the activities of anti-oxidative enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GRd) and decreased malondialdehyde (MDA) level in liver, as compared to those in the CCl4-treated group. Furthermore, SDGLEtOH(100 and 500 mg/kg) and silymarin attenuated the increased levels of tumor necrosis factor-α (TNF-α) in serum and nitric oxide ( NO ) in liver as compared to the CCl4-treated group. The hepatoprotective mechanisms of SDGLEtOHare likely related to inhibition of TNF-α, MDA and NO productions via increasing the activities of antioxidant enzymes (SOD, GPx and GRd). These experimental results suggest that SDGLEtOHcan attenuate CCl4-induced acute liver injury in rats.

Hepatoprotective effect of ghrelin on carbon tetrachloride-induced acute liver injury in rats

2011 ◽  
Vol 171 (1-3) ◽  
pp. 1-5 ◽  
Author(s):  
Ebru Çetin ◽  
Murat Kanbur ◽  
Nazmi Çetin ◽  
Gökhan Eraslan ◽  
Ayhan Atasever
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Hepatoprotective Effect
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