A 90-day toxicology study of high-amylose transgenic rice grain in Sprague–Dawley rats

2011 ◽  
Vol 49 (12) ◽  
pp. 3112-3118 ◽  
Author(s):  
Xing Hua Zhou ◽  
Ying Dong ◽  
Xiang Xiao ◽  
Yun Wang ◽  
Yong Xu ◽  
...  
Keyword(s):  
Transgenic Rice ◽  
Rice Grain ◽  
Sprague Dawley ◽  
Toxicology Study ◽  
Sprague Dawley Rats ◽  
High Amylose

A three generation reproduction study with Sprague–Dawley rats consuming high-amylose transgenic rice

2014 ◽  
Vol 74 ◽  
pp. 20-27 ◽  
Author(s):  
Xing Hua Zhou ◽  
Ying Dong ◽  
Yan Sheng Zhao ◽  
Xiang Xiao ◽  
Yun Wang ◽  
...  
Keyword(s):  
Transgenic Rice ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Reproduction Study ◽  
High Amylose

A 90-day toxicology study of transgenic lysine-rich maize grain (Y642) in Sprague–Dawley rats

2009 ◽  
Vol 47 (2) ◽  
pp. 425-432 ◽  
Author(s):  
Xiao Yun He ◽  
Mao Zhi Tang ◽  
Yun Bo Luo ◽  
Xin Li ◽  
Si Shuo Cao ◽  
...  
Keyword(s):  
Sprague Dawley ◽  
Toxicology Study ◽  
Sprague Dawley Rats ◽  
Maize Grain

A three generation study with high-lysine transgenic rice in Sprague–Dawley rats

2012 ◽  
Vol 50 (6) ◽  
pp. 1902-1910 ◽  
Author(s):  
Xing Hua Zhou ◽  
Ying Dong ◽  
Yun Wang ◽  
Xiang Xiao ◽  
Yong Xu ◽  
...  
Keyword(s):  
Transgenic Rice ◽  
Sprague Dawley ◽  
High Lysine ◽  
Sprague Dawley Rats

What is your diagnosis? Serum biochemical data from Sprague-Dawley rats in a toxicology study

2011 ◽  
Vol 40 (4) ◽  
pp. 559-560 ◽  
Author(s):  
Armando R. Irizarry Rovira ◽  
Bartley W. Halstead ◽  
Robert A. Jolly ◽  
Thomas K. Baker
Keyword(s):  
Biochemical Data ◽  
Sprague Dawley ◽  
Toxicology Study ◽  
Sprague Dawley Rats ◽  
Serum Biochemical

Chronic toxicity study in Sprague-Dawley rats on transgenic rice T1c-19 with cry1C* gene

2020 ◽  
Vol 140 ◽  
pp. 111324
Author(s):  
Xiaoqiao Tang ◽  
Yangfeng Wang ◽  
Lanjie Pei ◽  
Wenxiang Yang ◽  
Jun Fan ◽  
...  
Keyword(s):  
Transgenic Rice ◽  
Chronic Toxicity ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia–reperfusion injury in rats

2011 ◽  
Vol 107 (4) ◽  
pp. 485-492 ◽  
Author(s):  
Naomichi Nishimura ◽  
Hiroki Tanabe ◽  
Yumi Sasaki ◽  
Yui Makita ◽  
Misako Ohata ◽  
...  
Keyword(s):  
Dietary Fibre ◽  
Maize Starch ◽  
Sprague Dawley ◽  
Total Glutathione ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Sprague Dawley Rats ◽  
High Amylose ◽  
Dose Dependent Increase ◽  
Dose Dependent

We investigated whether the feeding of high H2-generating dietary fibre and resistant starch (RS) could suppress hepatic ischaemia–reperfusion (IR) injury, which results from oxidative stress, in rats fed a pectin (Pec) or high-amylose maize starch (HAS) diet. Male Sprague–Dawley rats were fed a control (C) diet, with or without Pec (0–5 % Pec) or HAS (0–30 % HAS) supplementation for 7 d. Portal H2 concentration showed a significant dose-dependent increase with the amount of Pec or HAS supplementation. Plasma alanine and aspartate aminotransferase activities remarkably increased in the C rats (5 % cellulose) due to IR treatment, while it decreased significantly or showed tendencies to decrease in 5 % Pec and 20 % HAS diet-fed rats. The hepatic oxidised glutathione (GSSG):total glutathione ratio increased significantly in IR rats maintained on the C diet compared with sham-operated rats. On the other hand, reduced glutathione (GSH):total glutathione and GSH:GSSG ratios decreased significantly. The GSSG:total glutathione ratio that increased due to IR treatment decreased significantly on HAS and Pec intake, while GSH:total glutathione and GSH:GSSG ratios increased significantly. Hepatic sinusoids of IR rats fed the C diet were occluded, but those of IR rats fed the Pec diet were similar to those in the sham-operated rats. In conclusion, we found that Pec or HAS, which enhance H2 generation in the large intestine, alleviated hepatic IR injury. The present study demonstrates another physiological significance of dietary fibre and RS.

A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results

2019 ◽  
Vol 132 ◽  
pp. 110728 ◽  
Author(s):  
L. Camacho ◽  
S.M. Lewis ◽  
M.M. Vanlandingham ◽  
G.R. Olson ◽  
K.J. Davis ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Sprague Dawley ◽  
Toxicology Study ◽  
Sprague Dawley Rats ◽  
Study Results ◽  
Core Study

scholarly journals A 90-Day Toxicology Study of Meat from Genetically Modified Sheep Overexpressing TLR4 in Sprague-Dawley Rats

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0121636 ◽  
Author(s):  
Hai Bai ◽  
Zhixian Wang ◽  
Rui Hu ◽  
Tongtong Kan ◽  
Yan Li ◽  
...  
Keyword(s):  
Genetically Modified ◽  
Sprague Dawley ◽  
Toxicology Study ◽  
Sprague Dawley Rats

scholarly journals Preclinical Acute Toxicology Study of Surfactant-Stabilized Ultrasound Contrast Agents in Adult Rats

2009 ◽  
Vol 29 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Flemming Forsberg ◽  
Ji-Bin Liu ◽  
Mihir Patel ◽  
Liping Liu ◽  
Ling Lin ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Clinical Signs ◽  
Blood Parameters ◽  
Ultrasound Contrast Agents ◽  
Dose Dependency ◽  
Sprague Dawley ◽  
Adult Rats ◽  
Toxicology Study ◽  
Ultrasound Contrast ◽  
Sprague Dawley Rats

Gas-filled microbubbles are used as contrast agents in diagnostic ultrasound imaging. A preclinical, acute toxicity study of 2 surfactant-stabilized ultrasound contrast agents (ST68 and ST44) was conducted. Subjects were 104 Sprague-Dawley rats (experimental doses, 0.1, 0.2, 0.8, and 1.0 mL/kg; control, 1.0 mL/kg saline) that were studied for 14 days after contrast; clinical signs, weight, blood, and urine were evaluated. Histopathology was performed following euthanasia. Of the 40 animals receiving ST44, 4 died prematurely and a dose dependency was demonstrated ( P = .011), whereas in the ST68 groups only 1 death occurred (no dose dependency; P = .48). Only the weight of rats injected with ST44 varied significantly ( P = .0003). This dependency was also found for 3 of 5 urine parameters and 4 of 36 blood parameters ( P < .05). For ST68, only 1 urine parameter showed significance ( P < .0001). Giant cell infiltration in the lungs was significantly higher than controls in the ST44 0.1 mL/kg and the ST68 0.8-1.0 mL/kg groups ( P < .01). It is concluded that the prudent choice for future nonrodent, toxicology studies and potentially for human clinical trials is ST68 (given the deaths in the ST44 groups).

Sign in / Sign up

Export Citation Format

Share Document