A 90-day toxicology study of transgenic lysine-rich maize grain (Y642) in Sprague–Dawley rats

2009 ◽  
Vol 47 (2) ◽  
pp. 425-432 ◽  
Author(s):  
Xiao Yun He ◽  
Mao Zhi Tang ◽  
Yun Bo Luo ◽  
Xin Li ◽  
Si Shuo Cao ◽  
...  
Keyword(s):  
Sprague Dawley ◽  
Toxicology Study ◽  
Sprague Dawley Rats ◽  
Maize Grain

Subchronic feeding study of DAS-59122-7 maize grain in Sprague-Dawley rats

2007 ◽  
Vol 45 (7) ◽  
pp. 1277-1292 ◽  
Author(s):  
Linda A. Malley ◽  
Nancy E. Everds ◽  
Julia Reynolds ◽  
Peter C. Mann ◽  
Ian Lamb ◽  
...  
Keyword(s):  
Sprague Dawley ◽  
Feeding Study ◽  
Sprague Dawley Rats ◽  
Maize Grain

Thirteen week feeding study with transgenic maize grain containing event DAS-Ø15Ø7-1 in Sprague–Dawley rats

2007 ◽  
Vol 45 (4) ◽  
pp. 551-562 ◽  
Author(s):  
Susan A. MacKenzie ◽  
Ian Lamb ◽  
Jean Schmidt ◽  
Lora Deege ◽  
Michael J. Morrisey ◽  
...  
Keyword(s):  
Transgenic Maize ◽  
Sprague Dawley ◽  
Feeding Study ◽  
Sprague Dawley Rats ◽  
Maize Grain

What is your diagnosis? Serum biochemical data from Sprague-Dawley rats in a toxicology study

2011 ◽  
Vol 40 (4) ◽  
pp. 559-560 ◽  
Author(s):  
Armando R. Irizarry Rovira ◽  
Bartley W. Halstead ◽  
Robert A. Jolly ◽  
Thomas K. Baker
Keyword(s):  
Biochemical Data ◽  
Sprague Dawley ◽  
Toxicology Study ◽  
Sprague Dawley Rats ◽  
Serum Biochemical

A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results

2019 ◽  
Vol 132 ◽  
pp. 110728 ◽  
Author(s):  
L. Camacho ◽  
S.M. Lewis ◽  
M.M. Vanlandingham ◽  
G.R. Olson ◽  
K.J. Davis ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Sprague Dawley ◽  
Toxicology Study ◽  
Sprague Dawley Rats ◽  
Study Results ◽  
Core Study

scholarly journals A 90-Day Toxicology Study of Meat from Genetically Modified Sheep Overexpressing TLR4 in Sprague-Dawley Rats

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0121636 ◽  
Author(s):  
Hai Bai ◽  
Zhixian Wang ◽  
Rui Hu ◽  
Tongtong Kan ◽  
Yan Li ◽  
...  
Keyword(s):  
Genetically Modified ◽  
Sprague Dawley ◽  
Toxicology Study ◽  
Sprague Dawley Rats

scholarly journals Preclinical Acute Toxicology Study of Surfactant-Stabilized Ultrasound Contrast Agents in Adult Rats

2009 ◽  
Vol 29 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Flemming Forsberg ◽  
Ji-Bin Liu ◽  
Mihir Patel ◽  
Liping Liu ◽  
Ling Lin ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Clinical Signs ◽  
Blood Parameters ◽  
Ultrasound Contrast Agents ◽  
Dose Dependency ◽  
Sprague Dawley ◽  
Adult Rats ◽  
Toxicology Study ◽  
Ultrasound Contrast ◽  
Sprague Dawley Rats

Gas-filled microbubbles are used as contrast agents in diagnostic ultrasound imaging. A preclinical, acute toxicity study of 2 surfactant-stabilized ultrasound contrast agents (ST68 and ST44) was conducted. Subjects were 104 Sprague-Dawley rats (experimental doses, 0.1, 0.2, 0.8, and 1.0 mL/kg; control, 1.0 mL/kg saline) that were studied for 14 days after contrast; clinical signs, weight, blood, and urine were evaluated. Histopathology was performed following euthanasia. Of the 40 animals receiving ST44, 4 died prematurely and a dose dependency was demonstrated ( P = .011), whereas in the ST68 groups only 1 death occurred (no dose dependency; P = .48). Only the weight of rats injected with ST44 varied significantly ( P = .0003). This dependency was also found for 3 of 5 urine parameters and 4 of 36 blood parameters ( P < .05). For ST68, only 1 urine parameter showed significance ( P < .0001). Giant cell infiltration in the lungs was significantly higher than controls in the ST44 0.1 mL/kg and the ST68 0.8-1.0 mL/kg groups ( P < .01). It is concluded that the prudent choice for future nonrodent, toxicology studies and potentially for human clinical trials is ST68 (given the deaths in the ST44 groups).

Ovarian changes in Sprague-Dawley rats produced by nocturnal exposure to low intensity light

1995 ◽  
Vol 29 (3) ◽  
pp. 335-338 ◽  
Author(s):  
Eric Beys ◽  
Gerhard J. Nohynek ◽  
Keyword(s):  
Control Group ◽  
Corpora Lutea ◽  
Light Cycle ◽  
Sprague Dawley ◽  
Dark Cycle ◽  
Control Female ◽  
Low Intensity ◽  
Toxicology Study ◽  
Sprague Dawley Rats ◽  
Minimal Intensity

This study was performed to investigate the potential effects of nocturnal, low-intensity light upon ovarian morphology of female Sprague-Dawley rats and to investigate the cause for ovarian changes which had been observed in an earlier study following transient exposure of control female Sprague-Dawley rats to indirect light of minimal intensity during the nocturnal 12-h dark cycle. Twenty female Sprague-Dawley CD rats (initial age: 5 weeks) were kept for 8 weeks under our standard laboratory conditions including a daily 12-h light cycle (light intensity: approximately 200 lux) followed by a 12-h dark cycle with exposure to an indirect light source of low intensity (approximately 30 lux). Ten female control rats of comparable age from a concurrent toxicology study housed in an adjacent animal room under our standard 12 h light/dark cycle served as controls. At the end of the study the rats were sacrificed, necropsied and the ovaries were evaluated histopathologically. In 5 of the 20 animals we found ovarian atrophy consisting of decreased number and size of corpora lutea and increased number of tertiary follicles and/or follicular cysts. Most corpora lutea present in these ovaries were old, indicating the absence of recent ovulations. In contrast, the incidence of ovarian changes in the control group was 0/10. In conclusion, nocturnal exposure of female Sprague-Dawley rats to light of minimal intensity produced a substantial incidence of ovarian changes and suggests that the incidence of ovarian atrophy observed in a previous study may have been due to transient exposure to indirect nocturnal light of minimal intensity.

A 90-day toxicology study of high-amylose transgenic rice grain in Sprague–Dawley rats

2011 ◽  
Vol 49 (12) ◽  
pp. 3112-3118 ◽  
Author(s):  
Xing Hua Zhou ◽  
Ying Dong ◽  
Xiang Xiao ◽  
Yun Wang ◽  
Yong Xu ◽  
...  
Keyword(s):  
Transgenic Rice ◽  
Rice Grain ◽  
Sprague Dawley ◽  
Toxicology Study ◽  
Sprague Dawley Rats ◽  
High Amylose
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