Saponins from the roots of Platycodon grandiflorum stimulate osteoblast differentiation via p38 MAPK- and ERK-dependent RUNX2 activation

2010 ◽  
Vol 48 (12) ◽  
pp. 3362-3368 ◽  
Author(s):  
Hyung Min Jeong ◽  
Eun Hee Han ◽  
Yun Hey Jin ◽  
Yong Pil Hwang ◽  
Hyung Gyun Kim ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Osteoblast Differentiation ◽  
Platycodon Grandiflorum ◽  
Stimulate Osteoblast Differentiation

Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK

2020 ◽  
Vol 35 (12) ◽  
pp. 1318-1325
Author(s):  
Mi‐Ae Kang ◽  
Jongsung Lee ◽  
See‐Hyoung Park
Keyword(s):  
P38 Mapk ◽  
Osteoblast Differentiation

Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation

Bone ◽  
2009 ◽  
Vol 45 (6) ◽  
pp. 1125-1132 ◽  
Author(s):  
Shinsuke Kido ◽  
Rika Kuriwaka-Kido ◽  
Takeshi Imamura ◽  
Yuji Ito ◽  
Daisuke Inoue ◽  
...  
Keyword(s):  
Mechanical Stress ◽  
Osteoblast Differentiation ◽  
Interleukin 11 ◽  
Stimulate Osteoblast Differentiation

scholarly journals Berberine Promotes Osteoblast Differentiation by Runx2 Activation With p38 MAPK

2008 ◽  
Vol 23 (8) ◽  
pp. 1227-1237 ◽  
Author(s):  
Hyun Woo Lee ◽  
Jung Hee Suh ◽  
Hyun-Nam Kim ◽  
A Young Kim ◽  
So Yun Park ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Osteoblast Differentiation

scholarly journals Peptide drugs accelerate BMP‐2‐induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling

BioEssays ◽  
2016 ◽  
Vol 38 (8) ◽  
pp. 717-725 ◽  
Author(s):  
Yasutaka Sugamori ◽  
Setsuko Mise‐Omata ◽  
Chizuko Maeda ◽  
Shigeki Aoki ◽  
Yasuhiko Tabata ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Osteoblast Differentiation ◽  
Peptide Drugs ◽  
Calvarial Bone ◽  
Mtorc1 Signaling ◽  
Stimulate Osteoblast Differentiation

scholarly journals Activation of p38 Mitogen-Activated Protein Kinase Is Required for Osteoblast Differentiation

Endocrinology ◽  
2003 ◽  
Vol 144 (5) ◽  
pp. 2068-2074 ◽  
Author(s):  
Yuanyu Hu ◽  
Emily Chan ◽  
Sherry X. Wang ◽  
Baojie Li
Keyword(s):  
Bone Marrow ◽  
P38 Mapk ◽  
Osteoblast Differentiation ◽  
Specific Inhibitor ◽  
Dominant Negative ◽  
Mitogen Activated Protein Kinase ◽  
Bone Morphogenetic Protein 2 ◽  
Differentiation Markers ◽  
Mineral Deposition ◽  
Calvarial Osteoblast

p38 MAPK is a conserved subfamily of MAPKs involved in inflammatory response, stress response, cell growth and survival, as well as differentiation of a variety of cell types. In this report we demonstrated that p38 MAPK played an important role in osteoblast differentiation using primary calvarial osteoblast, bone marrow osteoprecursor culture, and a murine cell line, MC3T3-E1. We found that p38 MAPK was activated as calvarial osteoblast differentiates along with extracellular signal-regulated kinases (ERKs). When p38 MAPK is inhibited with a specific inhibitor, the expression of differentiation markers, such as alkaline phosphatase and mineral deposition, were significantly reduced. MC3T3-E1 cells expressing dominant negative p38 MAPK also displayed signs of delay in ALP and mineral deposition. Differentiation of the bone marrow osteoprecursors was also impeded by the p38 MAPK inhibitor, justified by the same markers. Yet the inhibitory effects observed in calvarial osteoblasts and bone marrow osteoprogenitor cells could be partially prevailed by bone morphogenetic protein-2. Inhibition of ERKs with a specific drug did not significantly affect osteoblast differentiation even though ERK1/2 were also activated during osteoblast differentiation. These results taken together indicate that p38 MAPK, but not ERKs, is necessary for osteoblast differentiation.

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