Intrinsic apoptosis and NF-κB signaling are potential molecular targets for chemoprevention by black tea polyphenols in HepG2 cells in vitro and in a rat hepatocarcinogenesis model in vivo

2010 ◽  
Vol 48 (11) ◽  
pp. 3281-3287 ◽  
Author(s):  
R. Senthil Murugan ◽  
R. Vidya Priyadarsini ◽  
K. Ramalingam ◽  
Y. Hara ◽  
D. Karunagaran ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
Molecular Targets ◽  
Black Tea ◽  
Tea Polyphenols ◽  
Intrinsic Apoptosis ◽  
Black Tea Polyphenols

Prevention of diet-induced obesity by dietary black tea polyphenols extract in vitro and in vivo

Nutrition ◽  
2011 ◽  
Vol 27 (3) ◽  
pp. 287-292 ◽  
Author(s):  
Satoshi Uchiyama ◽  
Yoshimasa Taniguchi ◽  
Akiko Saka ◽  
Aruto Yoshida ◽  
Hiroaki Yajima
Keyword(s):  
Black Tea ◽  
Tea Polyphenols ◽  
Diet Induced Obesity ◽  
Black Tea Polyphenols

scholarly journals Colon Bioaccessibility and Antioxidant Activity of White, Green and Black Tea Polyphenols Extract after In Vitro Simulated Gastrointestinal Digestion

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1711 ◽  
Author(s):  
Giuseppe Annunziata ◽  
Maria Maisto ◽  
Connie Schisano ◽  
Roberto Ciampaglia ◽  
Patricia Daliu ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Inflammatory Diseases ◽  
Black Tea ◽  
Tea Polyphenols ◽  
Array Detector ◽  
Total Phenol Content ◽  
Beneficial Effects ◽  
Polyphenolic Extract

The beneficial effects of the tea beverage are well-known and mainly attributed to polyphenols which, however, have poor bioaccessibility and bioavailability. The purpose of the present study was the evaluation of colon bioaccessibility and antioxidant activity of tea polyphenolic extract. An 80% methanolic extract (v/v) of tea polyphenols was obtained from green (GT), white (WT) and black tea (BT). Simulated gastrointestinal (GI) digestion was performed on acid-resistant capsules containing tea polyphenolic extract. The main tea polyphenols were monitored by HPLC-diode-array detector (DAD) method; in addition, Total Phenol Content (TPC) and antioxidant activity were evaluated. After GI digestion, the bioaccessibility in the colon stage was significantly increased compared to the duodenal stage for both tea polyphenols and TPC. Similarly, the antioxidant activity in the colon stage was significantly higher than that in the duodenal stage. Reasonably, these results could be attributable in vivo to the activity of gut microbiota, which is able to metabolize these compounds, generating metabolites with a greater antioxidant activity. Our results may guide the comprehension of the colon digestion of polyphenols, suggesting that, although poorly absorbed in the duodenum, they can exert their antioxidant and anti-inflammatory activities in the lower gut, resulting in a novel strategy for the management of gut-related inflammatory diseases.

Anticlastogenic effects of black tea polyphenols theaflavins and thearubigins in human lymphocytes in vitro

2006 ◽  
Vol 20 (5) ◽  
pp. 608-613 ◽  
Author(s):  
Babli Halder ◽  
Swapan Pramanick ◽  
Sibabrata Mukhopadhyay ◽  
Ashok Kumar Giri
Keyword(s):  
Human Lymphocytes ◽  
Black Tea ◽  
Tea Polyphenols ◽  
Black Tea Polyphenols

Gene expression profiling of HepG2 cells after treatment with black tea polyphenols

BIOCELL ◽  
2018 ◽  
Vol 42 (3) ◽  
pp. 99-104 ◽  
Author(s):  
Jie ZHONG ◽  
Li DENG ◽  
Yu JIANG ◽  
Lianhong ZOU ◽  
Huabing YUAN ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Hepg2 Cells ◽  
Black Tea ◽  
Tea Polyphenols ◽  
Black Tea Polyphenols
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