28 Days repeated oral dose toxicity test of aqueous extracts of mahwangyounpae-tang, a polyherbal formula

2010 ◽  
Vol 48 (8-9) ◽  
pp. 2477-2482 ◽  
Author(s):  
Mee-Yeon Park ◽  
Hae-Yun Choi ◽  
Jong-Dae Kim ◽  
Hyeung-Sik Lee ◽  
Sae-Kwang Ku
Keyword(s):  
Oral Dose ◽  
Toxicity Test ◽  
Aqueous Extracts

scholarly journals Mouse Single Oral Dose Toxicity Test of Lactobacillus-fermented Araliae Continentalis Radix Aqueous Extracts (fACR)

2016 ◽  
Vol 26 (2) ◽  
pp. 204-211
Author(s):  
Young-Mi Jung ◽  
Sae-Kwang Ku ◽  
Dong Sub Lee ◽  
Kisang Kwon
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Toxicity Test ◽  
Aqueous Extracts

scholarly journals Mouse Single Oral Dose Toxicity Test of Bupleuri Radix Aqueous Extracts

2012 ◽  
Vol 28 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Kyung-Hu Kim ◽  
Cheol-Ou Gam ◽  
Seong-Hun Choi ◽  
Sae-Kwang Ku
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Toxicity Test ◽  
Aqueous Extracts ◽  
Bupleuri Radix

scholarly journals Single Oral Dose Toxicity Test of Persicae Semen Aqueous Extracts in Mice

2013 ◽  
Vol 28 (3) ◽  
pp. 17-24
Author(s):  
Hun-Bum Cho ◽  
Ji-Ha Park ◽  
Bu-Il Seo ◽  
Su-Yeon Cho ◽  
Kyu-Ryul Park ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Toxicity Test ◽  
Aqueous Extracts ◽  
Persicae Semen

scholarly journals Acute and sub-acute oral toxicity of aqueous whole leaf and green rind extracts of Aloe vera in Wistar rats

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Florence Nalimu ◽  
Joseph Oloro ◽  
Emanuel L. Peter ◽  
Patrick Engeu Ogwang
Keyword(s):  
Toxicity Test ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Aloe Vera ◽  
Female Rats ◽  
Male Rats ◽  
Aqueous Extracts ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Leaf Extracts

Abstract Background Several local communities in Central, Western, Eastern, and Northern regions of Uganda have been using the whole leaf extracts of Aloe vera (L.) Burm. f. (Asphodelaceae) in the treatment of various ailments. Also, several commercial companies sell A. vera as soft drinks in Uganda. However, there are inadequate reports on the toxicities of such preparations. This paper reports the acute and sub-acute oral toxicity of aqueous extracts of whole leaf and green rind of A. vera in Wistar rats. Methods Acute oral toxicity test was carried out in female Wistar rats at doses of 175, 550, 1750, and 5000 mg/kg, p.o. The animals were observed for signs of toxicity for 14 days. Similarly, a sub-acute oral toxicity test was performed in both sexes of rats at doses of 200, 400, and 800 mg/kg, p.o. daily for 28 days. All the groups of animals were monitored for behavioral, morphological, biochemical, and physiological changes, including mortality and compared with respective controls. Body weights were measured weekly while the animals’ relative organ weights, hematological, biochemical, gross, and microscopic pathology were examined on day 29. Results There was no mortality or apparent behavioral changes at the doses tested in acute and sub-acute oral toxicity tests. Thus, the Median Lethal Dose (LD50) of green rind and whole leaf aqueous extracts was above 5000 mg/kg. Gross anatomy revealed that the rats’ relative spleen weight in green rind extract at 200 mg/kg significantly decreased compared to the control group. The creatinine levels in female rats that received green rind extract and the chloride ion levels in male rats administered whole leaf extract were significantly elevated. Conversely, Mean Corpuscular Hemoglobin Concentration (MCHC) levels significantly decreased at lower doses of the green rind extract compared to the control. Histopathology of the kidney revealed the renal interstitium’s inflammation at doses of 200 and 800 mg/kg of the whole leaf extract. Conclusion The findings demonstrated that A. vera green rind and whole leaf extracts are non-toxic at relatively high doses when used for a short duration. Prolonged use of the aqueous whole leaf extract might be associated with kidney toxicity.

A 26-Week Repeated Oral Dose Toxicity Test and a 4-Week Recovery Test of Cassia tora L. Water Extract in Sprague-Dawley Rats

2018 ◽  
Vol 26 (2) ◽  
pp. 157-169
Author(s):  
Jong Hyun Nho ◽  
Jong Choon Kim ◽  
Hyun Woo Cho ◽  
Mu Jin Lee ◽  
Ho Kyung Jung ◽  
...  
Keyword(s):  
Oral Dose ◽  
Toxicity Test ◽  
Water Extract ◽  
Sprague Dawley ◽  
Cassia Tora ◽  
Recovery Test ◽  
Sprague Dawley Rats
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