Isolation, purification and identification of ellagic acid derivatives, catechins, and procyanidins from the root bark of Anisophyllea dichostyla R. Br.

2007 ◽  
Vol 45 (3) ◽  
pp. 472-485 ◽  
Author(s):  
F. Khallouki ◽  
R. Haubner ◽  
W.E. Hull ◽  
G. Erben ◽  
B. Spiegelhalder ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Root Bark ◽  
Ellagic Acid Derivatives

New Camptothecin and Ellagic Acid Analogues from the Root Bark ofCamptotheca acuminata

Planta Medica ◽  
2004 ◽  
Vol 70 (12) ◽  
pp. 1216-1221 ◽  
Author(s):  
Zhizhen Zhang ◽  
Shiyou Li ◽  
Shanmin Zhang ◽  
Chun Liang ◽  
David Gorenstein ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Root Bark

ChemInform Abstract: DNA Gyrase Inhibitory Activity of Ellagic Acid Derivatives.

ChemInform ◽  
2010 ◽  
Vol 29 (18) ◽  
pp. no-no
Author(s):  
M. A. WEIDNER-WELLS ◽  
J. ALTOM ◽  
J. FERNANDEZ ◽  
S. A. FRAGA-SPANO ◽  
J. HILLIARD ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Inhibitory Activity ◽  
Dna Gyrase ◽  
Ellagic Acid Derivatives

scholarly journals Cytotoxic and antioxidant potentials of ellagic acid derivatives from Conocarpus lancifolius (Combretaceae)

2020 ◽  
Vol 19 (5) ◽  
pp. 1037-1080
Author(s):  
Malik Saadullah ◽  
Muhammad Asif ◽  
Abdul Sattar ◽  
Kanwal Rehman ◽  
Shahid Shah ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Antioxidant Properties ◽  
Human Colon ◽  
Antioxidant Compounds ◽  
Phytochemical Analysis ◽  
Human Colon Cancer ◽  
Chemical Structures ◽  
Ellagic Acid Derivatives ◽  
Layer Chromatography

Purpose: Isolation, characterisation and structure elucidation of compounds obtained from Conocarpus lancifolius and screening of their pharmacological effects in vitro.Methods: After collection, authentication and extraction from whole C. lancifolius plants, screening for secondary metabolites, thin-layer  chromatography and subsequent open column chromatography were performed for phytochemical analysis and subsequent purification of the compounds. The chemical structures of the isolated compounds were elucidated using spectroscopic (UV-visible, infrared and mass) spectroscopy, and nuclear magnetic resonance (1H-NMR, 13C-NMR including BB, DEPT-135, 90 and two-dimensional correlation techniques, including HMBC and HSQC). The cytotoxic and antioxidant potentials of extracts and compounds obtained from C. lancifolius were evaluated using in vitro models.Results: Two ellagic acid derivatives, 2,3,8-tri-o-methylellagic acid (A) and 3-O-methylellagic acid 4-O-β-D-glucopyranoside (B), were isolated. Both compounds (A and B) were cytotoxic in a variety of cancer cell lines, including murine lymphocytic leukaemia (P-388, half-maximal inhibitory concentration (IC50) =3.60 and 2.40 μg/mL, respectively), human colon cancer (Col-2, IC50 = 0.76 and 0.92 μg/mL, respectively) and human breast cancer (MCF-7, IC50 = 0.65 and 0.54 μg/mL, respectively). Moreover, both compounds showed significant antioxidant potential in vitro.Conclusion: C. lancifolius extract and isolated ellagic acid derivatives (compounds A and B) possess cytotoxic and antioxidant properties. These findings suggest that C. lancifolius contains bioactive compounds that can be potentially developed as natural cytotoxic and antioxidant compounds. Keywords: Conocarpus lancifolius, Ellagic acid, Combretaceae, Cytotoxic activity, Antioxidant

scholarly journals Ellagic Acid Derivatives from Syzygium cumini Stem Bark: Investigation of their Antiplasmodial Activity

2009 ◽  
Vol 4 (10) ◽  
pp. 1934578X0900401 ◽  
Author(s):  
Claudia A. Simões-Pires ◽  
Sandra Vargas ◽  
Andrew Marston ◽  
Jean-Robert Ioset ◽  
Marçal Q. Paulo ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Ellagic Acid ◽  
Stem Bark ◽  
Antimalarial Drugs ◽  
Antiplasmodial Activity ◽  
Hydroxyl Groups ◽  
Syzygium Cumini ◽  
Free Hydroxyl ◽  
Ellagic Acid Derivatives

Bioguided fractionation of Syzygium cumini (Myrtaceae) bark decoction for antiplasmodial activity was performed, leading to the isolation of three known ellagic acid derivatives (ellagic acid, ellagic acid 4-O-α-L-2″-acetylrhamnopyranoside, 3-O-methylellagic acid 3′-O-α-L-rhamnopyranoside), as well as the new derivative 3-O-methylellagic acid 3′-O-β-D-glucopyranoside. Activity investigation was based on the reduction of P. falciparum (PfK1) parasitaemia in vitro and the inhibition of β-hematin formation, a known mechanism of action of some antimalarial drugs. Among the investigated ellagic acid derivatives, only ellagic acid was able to reduce P. falciparum parasitaemia in vitro and inhibit β-hematin formation, suggesting that free hydroxyl groups are necessary for activity within this class of compounds.

New Antioxidant and Antimicrobial Ellagic Acid Derivatives from Pteleopsis hylodendron

Planta Medica ◽  
2001 ◽  
Vol 67 (4) ◽  
pp. 335-339 ◽  
Author(s):  
Atta-Ur-Rahman ◽  
F. N. Ngounou ◽  
M. Iqbal Choudhary ◽  
Shahid Malik ◽  
Talat Makhmoor ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Ellagic Acid Derivatives

ChemInform Abstract: Ellagic Acid Derivatives from the Leaves of Eugenia jambos Linn.

ChemInform ◽  
2010 ◽  
Vol 30 (25) ◽  
pp. no-no
Author(s):  
Ajit Kumar Chakravarty ◽  
Binayak Das ◽  
Tapas Sarkar ◽  
Kazuo Masuda ◽  
Kenji Shiojima
Keyword(s):  
Ellagic Acid ◽  
Ellagic Acid Derivatives

DNA gyrase inhibitory activity of ellagic acid derivatives

1998 ◽  
Vol 8 (1) ◽  
pp. 97-100 ◽  
Author(s):  
Michele A Weidner-Wells ◽  
Jason Altom ◽  
Jeffrey Fernandez ◽  
Stephanie A Fraga-Spano ◽  
Jamese Hilliard ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Inhibitory Activity ◽  
Dna Gyrase ◽  
Ellagic Acid Derivatives
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