Chronic toxicity and carcinogenicity of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin displays a distinct dose/time toxicity threshold (c×t=k) and a life-prolonging subthreshold effect

2005 ◽  
Vol 43 (5) ◽  
pp. 729-740 ◽  
Author(s):  
Karl K. Rozman ◽  
Margitta Lebofsky ◽  
David M. Pinson
Keyword(s):  
Chronic Toxicity ◽  
Toxicity Threshold ◽  
Dose Time

Dose/time-dependent modulation of the endothelial function through immunosuppressive agents

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
I. Kanzler ◽  
N. Bogert ◽  
F. Guo ◽  
A. Moritz ◽  
A. Beiras-Fernandez
Keyword(s):  
Endothelial Function ◽  
Immunosuppressive Agents ◽  
Time Dependent ◽  
Dose Time

In Vitro Effects of Urokinase — Prevention by Different Inhibitors

1990 ◽  
Vol 64 (03) ◽  
pp. 402-406 ◽  
Author(s):  
M D Oethinger ◽  
E Seifried
Keyword(s):  
In Vitro Study ◽  
Thrombin Time ◽  
Plasma Samples ◽  
Temperature Dependent ◽  
Chloromethyl Ketone ◽  
Control Value ◽  
Dose Time ◽  
In Vitro Effects ◽  
Full Protection

SummaryThe present in vitro study investigated dose-, time- and temperature-dependent effects of two-chain urokinase plasminogen activato(u-PA, urokinase) on normal citrated plasma. When 10 μg/ml u-PA wereadded to pooled normal plasma and incubated for 30 min at an ambient temperature (25° C), α2-antiplas-min decreased to 8% of the control value. Incubation on ice yielded a decrease to 45% of control,whereas α2-antiplasmin was fully consumed at 37° C. Fibrinogen and plasminogen fell to 46% and 39%, respectively, after a 30 min incubation at 25° C. Thrombin time prolonged to 190% of control.Various inhibitors were studied with respect to their suitability and efficacy to prevent these in vitro effects. Aprotinin exhibited a good protective effect on fibrinogen at concentrations exceeding 500 KlU/ml plasma. Its use, however, was limited due to interferences with some haemostatic assays. We could demonstrate that L-Glutamyl-L-Glycyl-L-Arginyl chloromethyl ketone (GGACK) and a specific polyclonal anti-u-PA-antibody (anti-u-PA-IgG) effectively inhibited urokinase-induced plasmin generation without interfering with haemostatic assays. The anti-u-PA-antibody afforded full protection ofα2-antiplasmin at therapeutic levels of u-PA.It is concluded that u-PA in plasma samples from patients during thrombolytic therapy may induce in vitro effects which should be prevented by the use of a suitable inhibitor such as GGACK or specific anti-u-PA-antibody.

Carcinogenicity and Chronic Toxicity of Para-Chloronitrobenzene in Rats and Mice by Two-Year Feeding

2006 ◽  
Vol 25 (3) ◽  
pp. 571-584 ◽  
Author(s):  
Michiharu Matsumoto ◽  
Shigetoshi Aiso ◽  
Hideki Senoh ◽  
Kazunori Yamazaki ◽  
Heihachiro Arito ◽  
...  
Keyword(s):  
Chronic Toxicity ◽  
Rats And Mice

Acute and chronic toxicity studies on Polygonum glabrum in experimental animals

2020 ◽  
Vol 3 (1) ◽  
pp. 7-10
Author(s):  
Saravanakumar A ◽  
Gandhimathi R
Keyword(s):  
Chronic Toxicity ◽  
Clinical Stage ◽  
Herbal Medicines ◽  
Plant Roots ◽  
Root Extract ◽  
Experimental Animals ◽  
Toxicity Studies ◽  
Acute And Chronic Toxicity ◽  
Diuretic Agents

Polygonum glabrum is being used in traditional and folklore medicine to treat pneumonia and jaundice. Plant roots are used in ayurvedic preparations to treat fever and colic. The leaves are used as diuretic agents and process vermifuge action. Plant decoction is also used in the treatment of Rheumatism. Besides having many uses and folklore claims, herbal medicines are to be thoroughly investigated for their toxicity also. Therefore this work is being carried out to examine the toxicity of the drug and established dose is safe to use in the clinical stage. The current research studied the acute and chronic toxicity of Polygonum glabrum root extract in rats. It is proved that there was no change in any parameter tested both in acute and chronic toxicity, which means the extract is safe and non-toxic at the dose of 2g/kg also.

ECOLOGICAL AND TOXICOLOGICAL ASSESSMENT OF HAZARD, POSED BY WATER CONTAMINATION OF WATER BODIES WITH POLYVINYL NITRATE

2018 ◽  
pp. 12-19 ◽  
Author(s):  
A. A. Maslennikov ◽  
S. A. Demidova ◽  
A. V. Ryabova
Keyword(s):  
Biochemical Oxygen Demand ◽  
Water Contamination ◽  
Chronic Toxicity ◽  
Negative Impact ◽  
Oxygen Demand ◽  
Water Bodies ◽  
Organoleptic Properties ◽  
Toxicological Assessment ◽  
Threshold Levels ◽  
Polyvinyl Nitrate

Water containing polyvinyl nitrate was experimentally assessed on the basis of organoleptic, general sanitary and toxicological indicators of harmfulness. It was established that that the compound did not change water organoleptic properties but produced a negative impact on viability of saprophytic microflora , nitrification processes and biochemical oxygen demand. Besides, in tests on animals. the substance caused acute, sub-acute and chronic toxicity. Based on those signs of harmfulness, threshold levels of exposure were established. Data obtained were taken into account for substantiation of MAC (Maximum allowable concentration) of polyvinyl nitrate in water bodies.

Chronic toxicity of zinc sulphate in Procambarus clarkii

2013 ◽  
Vol 19 (1) ◽  
pp. 126-137
Author(s):  
Quan WANG ◽  
Jianguo WANG ◽  
Hongda LU ◽  
Liangwei XIONG ◽  
Jian AN
Keyword(s):  
Chronic Toxicity ◽  
Zinc Sulphate ◽  
Procambarus Clarkii

Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

2018 ◽  
Vol 68 (12) ◽  
pp. 2925-2918
Author(s):  
Gabriela Cioca ◽  
Maricel Agop ◽  
Marcel Popa ◽  
Simona Bungau ◽  
Irina Butuc
Keyword(s):  
Drug Release ◽  
Tannic Acid ◽  
Release Rate ◽  
Controlled Drug Release ◽  
Toxicity Threshold ◽  
Release System ◽  
Liposomal Formulations ◽  
Cross Linker ◽  
Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

Study of acute and chronic toxicity of homeopathic syrup Stodal

2020 ◽  
pp. 53-58
Author(s):  
S. V. Alekseeva ◽  
A. V. Sorokina ◽  
V. V. Zabrodina ◽  
I. A. Miroshkina ◽  
A. S. Lapitskaya
Keyword(s):  
Chronic Toxicity ◽  
Acute And Chronic Toxicity

Vitamin E as antioxidant in female african catfish (Clarias gariepinus) exposed to chronic toxicity of atrazine

2012 ◽  
Vol 16 (2) ◽  
pp. 83-98 ◽  
Author(s):  
Shadia Kadry ◽  
Afnan Amer ◽  
Mohamed Marzouk ◽  
Magdy Hanna ◽  
Amal Azmy ◽  
...  
Keyword(s):  
Vitamin E ◽  
Chronic Toxicity ◽  
Clarias Gariepinus ◽  
African Catfish
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