High homocysteine and epistasis between MTHFR and APOE: association with cognitive performance in the elderly

2016 ◽  
Vol 76 ◽  
pp. 9-16 ◽  
Author(s):  
Letizia Polito ◽  
Tino Emanuele Poloni ◽  
Roberta Vaccaro ◽  
Simona Abbondanza ◽  
Michela Mangieri ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
The Elderly

Effects of a Group Program to Increase Cognitive Performance Through Cognitively Stimulating Leisure Activities in Healthy Older Subjects

GeroPsych ◽  
2011 ◽  
Vol 24 (2) ◽  
pp. 83-92 ◽  
Author(s):  
Valentina A. Tesky ◽  
Christian Thiel ◽  
Winfried Banzer ◽  
Johannes Pantel
Keyword(s):  
Cognitive Function ◽  
Cognitive Performance ◽  
Older Persons ◽  
Intervention Program ◽  
Leisure Activities ◽  
The Elderly ◽  
Cognitive Stimulation ◽  
Group Program ◽  
Positive Effects ◽  
Older Subjects

To investigate the effects of leisure activities on cognitive performance of healthy older subjects, an innovative intervention program was developed. Frequent participation in cognitively stimulating activities (i.e., reading, playing chess, or playing music) is associated with reduced risk of dementia. AKTIVA (active cognitive stimulation – prevention in the elderly) is an intervention program designed to enhance cognitive stimulation in everyday life by increasing cognitive stimulating leisure activities. The present study determines the effects of AKTIVA on cognitive function, mood and attitude toward aging in a sample of older participants from the general population. Several measurement instruments were used including the Alzheimer’s Disease Assessment Scale (ADAS-Cog), the Trail-Making Test (TMT), and the Memory Complaint Questionnaire (MAC-Q). Initially, the sample consisted of 307 older persons (170 female, 72 ± 7 years). The intervention was evaluated with a randomized, controlled pre-post follow-up design. Participants were randomly assigned to one of three conditions: AKTIVA intervention (n = 126), AKTIVA intervention plus nutrition and exercise counseling (n = 84), no-intervention control group (n = 97). The AKTIVA intervention consisted of 8 weekly sessions and two booster sessions after a break of 4 months. Participation in the group program resulted in positive effects on cognitive function and attitude toward aging for subassembly groups. Older persons (≥ 75 years) showed enhanced speed of information processing (by TMT Version A) (F = 4.17*, p < .05); younger participants (< 75 years) showed an improvement in subjective memory decline (by MAC-Q) (F = 2.55*, p < .05). Additionally, AKTIVA enhanced the frequency of activities for leisure activities for subassembly groups. The results of this study suggest that the AKTIVA program can be used to increase cognitively stimulating leisure activities in the elderly. Further research is necessary to identify the long-term effects of this intervention particularly with respect to the prevention of dementia.

scholarly journals Evidence for the association of the S100β gene with low cognitive performance and dementia in the elderly

2007 ◽  
Vol 12 (9) ◽  
pp. 870-880 ◽  
Author(s):  
J-C Lambert ◽  
S Ferreira ◽  
J Gussekloo ◽  
L Christiansen ◽  
G Brysbaert ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
The Elderly

scholarly journals Prevalência, desempenho cognitivo e funcionalidade de idosos com Doença de Alzheimer em instituições de longa permanência de Bento Gonçalves

2017 ◽  
Vol 5 (1) ◽  
pp. 23 ◽  
Author(s):  
Daniela Fernandes Tonholi ◽  
Gisele Oltramari
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Performance ◽  
Junior High School ◽  
Functional Independence Measure ◽  
The Elderly ◽  
Functional Independence ◽  
Cross Sectional Study ◽  
Functional Evaluation ◽  
Cross Sectional

Aims: To determine the prevalence, cognitive performance and functionality of elderly people with Alzheimer's disease in long-stay institutions for the elderlyin the city of Bento Gonçalves. Methods: Cross-sectional study including 24 elderly residents in long-stay institutions for the elderly, sociodemographic datawere obtained, and the elderly were subjected to functional evaluation by the Functional Independence Measure and evaluation of cognitive performancethrough the mental state the Mini (MMSE). Results: Most of the residents were female (83%), as 54.2% schooling had completed junior high school, mostof the elderly (70.8%) was admitted by the will of the family, 100% of the elderly showed cognitive performance bad, and the smaller the more dependentcognitive performance was the individual. Conclusion: institutionalized elderly with Alzheimer's disease had negative results on cognitive performance,as well as deficits in their ability to perform activities of daily living, thus altering their functionality.Keywords: aging; functionality; cognition; Alzheimer Disease; long-stay institutions.

scholarly journals Cognitive reserve in elderly: neuropsychological aspects and the education role in the latest findings

2015 ◽  
Vol 94 (3) ◽  
pp. 136
Author(s):  
João Gabriel Magalhães Dias ◽  
Pablo Rodrigo Andrade da Silva ◽  
Tânia Corrêa de Toledo Ferraz Alvez
Keyword(s):  
Executive Function ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Cognitive Abilities ◽  
Elderly Population ◽  
Cognitive Reserve ◽  
The Elderly ◽  
Cortical Atrophy ◽  
Print Exposure ◽  
Cognitive Markers

The elderly population is growing worldwide, and therefore cognitive decline and dementia is a major problem for healthcare system. However, many elders do not develop dementia or significant cognitive impairment even though present brain lesions, such as cortical atrophy and/or lesions, leading to the concept of Cognitive Reserve (CR). The main objective of this review is to establish the recent findings of CR in elderly cognition and explore some of the cognitive markers related to CR. In order to accomplish that we carried out a search for papers published either in English or Portuguese language in the last 5 years in the Medline database using as keywords cognitive reserve, elderly and aging/ageing. We filtered 14 studies that specifically approached the neuropsychological aspects (e.g, memory, attention, orientation, executive function) and reviewed them in detail. Based on these papers regarding old-aged individuals, education appears to have several implications on CR by strengthening cognitive abilities, however does not appear to impact on cognitive decline. Besides, we realized that cognitive performance is one of the form to measure CR, even though the methods cannot be standardized, which may be the cause of some varied conclusions. Regarding CR, education was the most prevalent measure, and CR seems to have a beneficial effect on executive function and episodic memory and it seems to act by both neural reserve and neural compensation. Print exposure appears as a potential variable positively related to cognitive performance and CR.

scholarly journals Comparison of the cognitive performance of elderly caregivers with and without chronic pain

2017 ◽  
Vol 51 (0) ◽  
Author(s):  
Marielli Terassi ◽  
Estefani Serafim Rossetti ◽  
Karina Gramani-Say ◽  
Tiago da Silva Alexandre ◽  
Priscilla Hortense ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Data Collection ◽  
Cognitive Performance ◽  
Scientific Knowledge ◽  
Elderly Person ◽  
Family Health ◽  
The Elderly ◽  
Initial Hypothesis ◽  
Objective Understanding ◽  
Elderly Caregivers

Abstract OBJECTIVE Understanding and characterizing chronic pain in elderly caregivers, verifying the cognitive performance of the elderly of the sample and verifying whether there is difference in the cognitive performance of elderly caregivers with and without chronic pain. METHOD Participants were people aged 60 years or older who lived with another elderly person in the same household and who were registered in Family Health Units. Data collection took place at participants' homes. Pain was assessed by the EMADOR and cognition was assessed by ACE-R. Statistical analyzes were performed using Shapiro-Wilk's and Mann-Whitney U tests. RESULTS The study included 187 elderly caregivers with chronic pain and 133 without chronic pain, with a higher frequency of women. Chronic pain was present in 58.4% of the participants. Regarding the sociodemographic variables, there was no difference between the groups except for the gender variable (p=0.025). No difference was found in cognitive performance among the elderly with chronic pain and those without chronic pain for any domain of the ACE-R instrument. CONCLUSION The results contradicted the initial hypothesis that there would be a difference between the groups; however, there is a gap in the scientific knowledge on chronic pain and cognition, especially in elderly caregivers, opening perspectives for future investigations.

scholarly journals Effect of Milk and Other Dairy Products on the Risk of Frailty, Sarcopenia, and Cognitive Performance Decline in the Elderly: A Systematic Review

2019 ◽  
Vol 10 (suppl_2) ◽  
pp. S105-S119 ◽  
Author(s):  
Federico Cuesta-Triana ◽  
Carlos Verdejo-Bravo ◽  
Cristina Fernández-Pérez ◽  
Francisco J Martín-Sánchez
Keyword(s):  
Systematic Review ◽  
Cognitive Performance ◽  
Dairy Products ◽  
The Elderly ◽  
Performance Decline

Prestroke Physical Activity and Poststroke Cognitive Performance

2020 ◽  
Vol 49 (6) ◽  
pp. 632-638
Author(s):  
Andreas Gammelgaard Damsbo ◽  
Janne Kaergaard Mortensen ◽  
Kristian Lundsgaard Kraglund ◽  
Søren Paaske Johnsen ◽  
Grethe Andersen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cognitive Impairment ◽  
Functional Outcome ◽  
Cognitive Performance ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Protective Measure ◽  
Multivariable Analyses ◽  
State Examination ◽  
Physical Activity Scale

<b><i>Introduction:</i></b> Physical activity (PA) is associated with a lower risk of stroke and stroke mortality as well as a favorable stroke outcome. PA may also prevent general cognitive decline. Poststroke cognitive impairment is both common and disabling, and focusing on all possible preventive measures is important. Studies on the effect of PA on poststroke cognitive performance are sparse, however. We therefore aimed to examine the association between prestroke PA and poststroke cognitive performance. <b><i>Methods:</i></b> We studied the correlation between prestroke PA and poststroke cognitive performance in a prespecified analysis in The Efficacy of Citalopram Treatment in Acute Ischemic Stroke (TALOS) trial. We used the Physical Activity Scale for the Elderly (PASE) to collect information on PA during the 7-day period before stroke. PA was quantified, and patients were stratified into quartiles based on their PASE score. Cognitive performance was measured using the Symbol Digit Modalities Test (SDMT) at 1 and 6 months and the Mini-Mental State Examination (MMSE) at 6 months. The functional outcome was assessed using the modified Rankin Scale (mRS). <b><i>Results:</i></b> In total, 625 of 642 patients (97%) completed the PASE questionnaire. The median age was 69 (interquartile range [IQR]: 60–77), and the median PASE score was 137 (82–205). Higher prestroke PASE quartiles (2nd, 3rd, and 4th, each compared to the 1st) were independently associated with a higher SDMT score at 1 month in the both the univariable and multivariable analyses (2nd: 3.99 points, 95% confidence interval [CI]: 1.01–6.97; 3rd: 3.6, CI: 0.6–6.61; 4th: 4.1, CI: 0.95–7.24). This association remained at 6 months. PA was not statistically associated with the MMSE score or mRS. <b><i>Conclusion:</i></b> Higher prestroke PA was associated with a better cognitive performance as measured by the SDMT at 1 and 6 months poststroke. We found no significant association between prestroke PA and functional outcome. Our results are encouraging and support further investigations of PA as a protective measure against poststroke cognitive impairment.

scholarly journals Impact of cognitive performance on the functional capacity of an elderly population in Natal, Brazil

2008 ◽  
Vol 66 (4) ◽  
pp. 809-813 ◽  
Author(s):  
Keithlen Cruz Moreira de Castro ◽  
Ricardo Oliveira Guerra
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Performance ◽  
Functional Capacity ◽  
Elderly Population ◽  
Population Sample ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Elderly Persons ◽  
Cross Sectional ◽  
State Examination

Functional incapacity and cognitive impairment are conditions related to the process of human aging. Cognitive impairment is considered an important predicitve factor for functional impairment in elderly populations. This cross-sectional study analyzes the association between cognitive performance and functional capacity in an elderly population sample in Natal, Brazil. A total of 213 elderly persons were assessed by the BOAS Multidimensional Questionnaire (Brazil Old Age Schedule) and the Mini-Mental State Examination (MMSE). The results of multivariate analysis and linear regression showed that age and schooling level are factors associated with cognitive performance in the elderly of this study. The final explicative model, elaborated by logistic regression, found that cognitive performance was the only predicitve variable of functional incapacity for the activities of daily living even when adjusted for sociodemographic variables.

scholarly journals Intense physical activity is associated with cognitive performance in the elderly

2012 ◽  
Vol 2 (11) ◽  
pp. e191-e191 ◽  
Author(s):  
B M Brown ◽  
◽  
J J Peiffer ◽  
H R Sohrabi ◽  
A Mondal ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cognitive Performance ◽  
The Elderly ◽  
Intense Physical Activity
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