Low-dose and combined effects of oral exposure to bisphenol A and diethylstilbestrol on the male reproductive system in adult Sprague-Dawley rats

2016 ◽  
Vol 43 ◽  
pp. 94-102 ◽  
Author(s):  
Xiao Jiang ◽  
Hong-qiang Chen ◽  
Zhi-hong Cui ◽  
Li Yin ◽  
Wen-long Zhang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Reproductive System ◽  
Low Dose ◽  
Male Reproductive System ◽  
Oral Exposure ◽  
Combined Effects ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Oral exposure to low-dose bisphenol A induces hyperplasia of dorsolateral prostate and upregulates EGFR expression in adult Sprague-Dawley rats

2019 ◽  
Vol 35 (10) ◽  
pp. 647-659 ◽  
Author(s):  
Shuangshuang Wu ◽  
Dongyan Huang ◽  
Xin Su ◽  
Han Yan ◽  
Jianhui Wu ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Low Dose ◽  
Synergetic Effect ◽  
Oral Exposure ◽  
Signal Pathways ◽  
Sprague Dawley ◽  
Sd Rats ◽  
Egfr Expression ◽  
Endocrine Hormone ◽  
Prostate Diseases

Prostate is sensitive to endocrine hormone level, and the synergetic effect of estrogen and androgen is critical in prostate growth. The change of signal pathways caused by the imbalance of estrogen and androgen might function in the occurrence of prostate diseases. As a well-known endocrine disruptor compound, bisphenol A (BPA) can disturb the normal function of endocrine hormone and affect prostate development. This study aims to investigate effects of BPA on the dorsolateral prostate (DLP) and the related gene expression of the tissue in adult Sprague- Dawley (SD) rats and to explore the mechanism for the effect of low-dose BPA on DLP hyperplasia. Three-month-old male SD rats were treated with BPA (10.0, 30.0, or 90.0 µg (kg.day)−1, gavage) or vehicle (gavage) for 4 weeks. BPA significantly increased the DLP weight, the DLP organ coefficient, and the prostate epithelium height ( p < 0.01) of rats dose-dependently. Microarray analysis and quantitative real-time polymerase chain reaction showed that BPA significantly upregulated the transcriptional levels of some genes, including pituitary tumor transforming gene 1, epidermal growth factor, Sh3kbp1, and Pcna. Furthermore, the expression of PCNA ( p < 0.01), androgen receptor ( p < 0.01), and EGF receptor (EGFR) ( p < 0.001) in DLP was increased significantly by BPA treatment, and the expression of estrogen receptor alpha was also upregulated. The findings evidenced that low-dose BPA could induce DLP hyperplasia in adult rats, and the upregulated EGF/EGFR pathway that was responsive to estrogen and androgen might play an essential role in the DLP hyperplasia induced by low-dose BPA.

scholarly journals Dose-dependent acceleration in the delayed effects of neonatal oral exposure to low-dose 17α-ethynylestradiol on reproductive functions in female Sprague-Dawley rats

2015 ◽  
Vol 40 (6) ◽  
pp. 727-738 ◽  
Author(s):  
Mariko Shirota ◽  
Jun Kawashima ◽  
Tomohiro Nakamura ◽  
Junichi Kamiie ◽  
Kinji Shirota ◽  
...  
Keyword(s):  
Low Dose ◽  
Oral Exposure ◽  
Sprague Dawley ◽  
Delayed Effects ◽  
Sprague Dawley Rats ◽  
Dose Dependent

LOW DOSE MIXTURE EFFECTS OF BISPHENOL A AND ISOBUTYLPARABEN FOR THE MALE REPRODUCTIVE SYSTEM

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Yun-jung Yang ◽  
Mun-seo Park ◽  
Sang-yon Kim ◽  
Lee-so Maeng ◽  
Soon-chul Myoung ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Reproductive System ◽  
Low Dose ◽  
Male Reproductive System ◽  
Mixture Effects

Independent and Combined Effects of Bisphenol A and Diethylhexyl Phthalate on Gestational Outcomes and Offspring Development in Sprague‐Dawley Rats

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Josephine Bou Dagher ◽  
Elyssa Campbell ◽  
Amrita Kaimal ◽  
Coral Hahn-Townsend ◽  
Maryam Hazim Al Mansi ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Combined Effects ◽  
Sprague Dawley ◽  
Diethylhexyl Phthalate ◽  
Offspring Development ◽  
Sprague Dawley Rats

Independent and combined effects of Bisphenol A and Diethylhexyl Phthalate on gestational outcomes and offspring development in Sprague-Dawley rats

Chemosphere ◽  
2021 ◽  
Vol 263 ◽  
pp. 128307
Author(s):  
Josephine Bou Dagher ◽  
Coral K. Hahn-Townsend ◽  
Amrita Kaimal ◽  
Maryam Al Mansi ◽  
Joseph E. Henriquez ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Combined Effects ◽  
Sprague Dawley ◽  
Diethylhexyl Phthalate ◽  
Offspring Development ◽  
Sprague Dawley Rats

scholarly journals Oral exposure to low-dose of nonylphenol impairs memory performance in Sprague-Dawley rats

2015 ◽  
Vol 40 (1) ◽  
pp. 43-53 ◽  
Author(s):  
Shinichiro Kawaguchi ◽  
Rika Kuwahara ◽  
Yumi Kohara ◽  
Yutaro Uchida ◽  
Yushi Oku ◽  
...  
Keyword(s):  
Low Dose ◽  
Memory Performance ◽  
Oral Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Bisphenol-A Dose-dependently Regulates The Development of Ovary and Uterus through Differential Expression of METTL3

2020 ◽  
Author(s):  
Zhe Zhang ◽  
Yuan Zhu ◽  
Zhifan Zhang ◽  
Daojuan Wang ◽  
Hongwei Wang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Soybean Oil ◽  
Reproductive System ◽  
Low Dose ◽  
Polycystic Ovary ◽  
Female Rats ◽  
Control Group ◽  
Sprague Dawley ◽  
Blank Group ◽  
Rna Methylation

Abstract Background: Environmental endocrine disruptors, which have a profound impact on the reproductive system, can cause endocrine and reproductive disorders, such as polycystic ovary syndrome (PCOS). Bisphenol-A (BPA) is a common endocrine disruptor which can affect the function of the reproductive system under low-dose conditions. However, the mechanism by which this molecule disrupts normal reproduction is still unclear. In this study, we investigated the effects of BPA on the RNA methyltransferase METTL3 in adolescent female rats which may be a possible mode of action of BPA. Methods: 4-week-old Sprague-Dawley (SD) rats were intragastrically treated for 10 weeks, which were divided into blank group (n = 8), control group (soybean oil, n = 8), three BPA-treatment groups (0.5 mg/kg BPA + soybean oil, 5 mg/kg BPA + soybean oil, 50 mg/kg BPA + soybean oil, n = 8). Results: The results showed that low-dose BPA (0.5 mg/kg) increased the coefficient of uteri and ovaries, and promoted the growth of uteri in rats without causing hyperandrogenism and ovarian polycystic changes. Oral BPA disturbed the expression of CYP17A1, CYP11A1 and METTL3 in ovaries and effected the level of serum testosterone. Conclusions: Our results suggested that oral BPA might interfere uterine and ovarian morphology and the level of hormone with RNA methylation by disturbing the expression level of METTL3. RNA methylation will be a new way to explain the interference mechanism of BPA.

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