Advanced adipose-derived stem cell protein extracts with antioxidant activity modulates matrix metalloproteinases in human dermal fibroblasts

2012 ◽  
Vol 34 (2) ◽  
pp. 263-271 ◽  
Author(s):  
Yong-Byung Chae ◽  
Jae Seol Lee ◽  
Hye-Jung Park ◽  
In-Hwan Park ◽  
Moon-Moo Kim ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Stem Cell ◽  
Matrix Metalloproteinases ◽  
Dermal Fibroblasts ◽  
Cell Protein ◽  
Human Dermal Fibroblasts ◽  
Adipose Derived Stem Cell

SIRT1 modulates expression of matrix metalloproteinases in human dermal fibroblasts

2010 ◽  
Vol 163 (4) ◽  
pp. 689-694 ◽  
Author(s):  
K. Ohguchi ◽  
T. Itoh ◽  
Y. Akao ◽  
H. Inoue ◽  
Y. Nozawa ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts

scholarly journals Inonotus obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis

Cosmetics ◽  
2020 ◽  
Vol 7 (2) ◽  
pp. 36
Author(s):  
Young Joo Kim ◽  
Hwa Jun Cha
Keyword(s):  
Oxidative Stress ◽  
Matrix Metalloproteinases ◽  
Mrna Expression ◽  
Transcriptional Activity ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Inonotus Obliquus ◽  
The Family ◽  
Normal Human ◽  
Normal Human Dermal Fibroblasts

Inonotus obliquus, which is parasitic on birch and other trees, is a fungus in the family Hymenochaetaceae. In this study, we investigated whether Inonotus obliquus extracts used in traditional medicine were decreased in the expression of matrix metalloproteinases-1 (MMP-1) in the normal human dermal fibroblasts. As shown in our results, extracts of Inonotus obliquus decreased MMP1 expression in oxidative stress-exposed normal human dermal fibroblasts. Additionally, Inonotus obliquus extracts decreased AP-1 transcriptional activity and phospho-JNK in oxidative stress-exposed normal human dermal fibroblasts. Oxidative stress mediated the elevation of MMP1 mRNA expression and was well regulated by the JNK-AP-1 axis. Therefore, the results suggest that Inonotus obliquus extracts decreased MMP1 mRNA expression by regulating JNK-AP-1 axis. Additionally, Inonotus obliquus extracts have the potential to reduce collagen destruction and the formation of wrinkles and to be used as a cosmetic ingredient.

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