Michelia alba extract attenuates UVB-induced expression of matrix metalloproteinases via MAP kinase pathway in human dermal fibroblasts

2012 ◽  
Vol 50 (12) ◽  
pp. 4260-4269 ◽  
Author(s):  
Hsiu-Mei Chiang ◽  
Hsin-Chun Chen ◽  
Tsen-Jung Lin ◽  
I-Chen Shih ◽  
Kuo-Ching Wen
Keyword(s):  
Matrix Metalloproteinases ◽  
Map Kinase ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Induced Expression ◽  
Map Kinase Pathway ◽  
Kinase Pathway

scholarly journals Complementation of Defective Colony-Stimulating Factor 1 Receptor Signaling and Mitogenesis by Raf and v-Src

1999 ◽  
Vol 19 (2) ◽  
pp. 1101-1115 ◽  
Author(s):  
Natasha Aziz ◽  
Holly Cherwinski ◽  
Martin McMahon
Keyword(s):  
Map Kinase ◽  
Cyclin D1 ◽  
Colony Stimulating Factor ◽  
3T3 Cells ◽  
Mitogenic Response ◽  
Induced Expression ◽  
Map Kinase Pathway ◽  
Nih 3T3 ◽  
Kinase Pathway ◽  
Stimulating Factor

ABSTRACT Ras-activated signal transduction pathways are implicated in the control of cell proliferation, differentiation, apoptosis, and tumorigenesis, but the molecular mechanisms mediating these diverse functions have yet to be fully elucidated. Conditionally active forms of Raf, v-Src, and MEK1 were used to identify changes in gene expression that participate in oncogenic transformation, as well as in normal growth control. Activation of Raf, v-Src, and MEK1 led to induced expression of c-Myc and cyclin D1. Induction of c-Myc mRNA by Raf was an immediate-early response, whereas the induction of cyclin D1 mRNA was delayed and inhibited by cycloheximide. Raf activation also resulted in the induction of an established c-Myc target gene, ornithine decarboxylase (ODC). ODC induction by Raf was mediated, in part, by tandem E-boxes contained in the first intron of the gene. Activation of the human colony-stimulating factor 1 (CSF-1) receptor in NIH 3T3 cells leads to activation of the mitogen-activated protein (MAP) kinase pathway and induced expression of c-Fos, c-Myc, and cyclin D1, leading to a potent mitogenic response. By contrast, a mutated form of this receptor fails to activate the MAP kinases or induce c-Myc and cyclin D1 expression and fails to elicit a mitogenic response. The biological significance of c-Myc and cyclin D1 induction by Raf and v-Src was confirmed by the demonstration that both of these protein kinases complemented the signaling and mitogenic defects of cells expressing this mutated form of the human CSF-1 receptor. Furthermore, the induction of c-Myc and cyclin D1 by oncogenes and growth factors was inhibited by PD098059, a specific MAP kinase kinase (MEK) inhibitor. These data suggest that the Raf/MEK/MAP kinase pathway plays an important role in the regulation of c-Myc and cyclin D1 expression in NIH 3T3 cells. The ability of oncogenes such as Raf and v-Src to regulate the expression of these proteins reveals new lines of communication between cytosolic signal transducers and the cell cycle machinery.

cAMP-induced expression of ABCA1 is associated with MAP-kinase-pathway activation

2007 ◽  
Vol 363 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Thomas Witzlack ◽  
Tina Wenzeck ◽  
Joachim Thiery ◽  
Matthias Orth
Keyword(s):  
Map Kinase ◽  
Induced Expression ◽  
Pathway Activation ◽  
Map Kinase Pathway ◽  
Kinase Pathway

577: The RAF/MAP Kinase Pathway Influences Survival in Androgen-Insensitive Prostate Cancer

2005 ◽  
Vol 173 (4S) ◽  
pp. 157-158
Author(s):  
Rono Mukherjee ◽  
Sarath K. Nalagatla ◽  
Mark A. Undenvood ◽  
John M.S. Bartlett ◽  
Joanne Edwards
Keyword(s):  
Prostate Cancer ◽  
Map Kinase ◽  
Map Kinase Pathway ◽  
Kinase Pathway

SIRT1 modulates expression of matrix metalloproteinases in human dermal fibroblasts

2010 ◽  
Vol 163 (4) ◽  
pp. 689-694 ◽  
Author(s):  
K. Ohguchi ◽  
T. Itoh ◽  
Y. Akao ◽  
H. Inoue ◽  
Y. Nozawa ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts
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