scholarly journals Maternal phthalate exposure during pregnancy is associated with DNA methylation of LINE-1 and Alu repetitive elements in Mexican-American children

2016 ◽  
Vol 148 ◽  
pp. 55-62 ◽  
Author(s):  
Karen Huen ◽  
Antonia M. Calafat ◽  
Asa Bradman ◽  
Paul Yousefi ◽  
Brenda Eskenazi ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mexican American ◽  
Repetitive Elements ◽  
Phthalate Exposure ◽  
Exposure During Pregnancy ◽  
American Children

scholarly journals DNA methylation of LINE-1 and Alu repetitive elements in relation to sex hormones and pubertal timing in Mexican-American children

2016 ◽  
Vol 79 (6) ◽  
pp. 855-862 ◽  
Author(s):  
Karen Huen ◽  
Kim Harley ◽  
Katherine Kogut ◽  
Stephen Rauch ◽  
Brenda Eskenazi ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Sex Hormones ◽  
Mexican American ◽  
Pubertal Timing ◽  
Repetitive Elements ◽  
American Children

scholarly journals Maternal bisphenol a exposure during pregnancy and its association with adipokines in Mexican-American children

2013 ◽  
Vol 54 (8) ◽  
pp. 621-628 ◽  
Author(s):  
Vitaly Volberg ◽  
Kim Harley ◽  
Antonia M. Calafat ◽  
Veronica Davé ◽  
Jessica McFadden ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Mexican American ◽  
Exposure During Pregnancy ◽  
American Children

scholarly journals DNA methylation of imprinted genes in Mexican–American newborn children with prenatal phthalate exposure

Epigenomics ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 1011-1026 ◽  
Author(s):  
Gwen Tindula ◽  
Susan K Murphy ◽  
Carole Grenier ◽  
Zhiqing Huang ◽  
Karen Huen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mexican American ◽  
Imprinted Genes ◽  
Phthalate Exposure ◽  
Newborn Children

Prenatal phthalate exposure, birth outcomes and DNA methylation of Alu and LINE-1 repetitive elements: A pilot study in China

Chemosphere ◽  
2018 ◽  
Vol 206 ◽  
pp. 759-765 ◽  
Author(s):  
Li-Li Huang ◽  
Bin Zhou ◽  
Song-Hua Ai ◽  
Pan Yang ◽  
Ying-Jun Chen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Pilot Study ◽  
Birth Outcomes ◽  
Repetitive Elements ◽  
Phthalate Exposure

scholarly journals PON1 DNA methylation and neurobehavior in Mexican-American children with prenatal organophosphate exposure

2018 ◽  
Vol 121 ◽  
pp. 31-40 ◽  
Author(s):  
Karen Huen ◽  
Olivia Solomon ◽  
Katherine Kogut ◽  
Brenda Eskenazi ◽  
Nina Holland
Keyword(s):  
Dna Methylation ◽  
Mexican American ◽  
American Children

scholarly journals Epigenome-wide association study of lung function in Latino children and youth with asthma

2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Esther Herrera-Luis ◽  
Annie Li ◽  
Angel C. Y. Mak ◽  
Javier Perez-Garcia ◽  
Jennifer R. Elhawary ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Lung Function ◽  
Association Study ◽  
Whole Blood ◽  
Mexican Americans ◽  
Mexican American ◽  
Puerto Ricans ◽  
Cpg Sites ◽  
Significance Threshold ◽  
American Children

Abstract Introduction DNA methylation studies have associated methylation levels at different CpG sites or genomic regions with lung function. Moreover, genetic ancestry has been associated with lung function in Latinos. However, no epigenome-wide association study (EWAS) of lung function has been performed in this population. Here, we aimed to identify DNA methylation patterns associated with lung function in pediatric asthma among Latinos. Results We conducted an EWAS in whole blood from 250 Puerto Rican and 148 Mexican American children and young adults with asthma. A total of five CpGs exceeded the genome-wide significance threshold of p = 1.17 × 10−7 in the combined analyses from Puerto Ricans and Mexican Americans: cg06035600 (MAP3K6, p = 6.13 × 10−8) showed significant association with pre-bronchodilator Tiffeneau–Pinelli index, the probes cg00914963 (TBC1D16, p = 1.04 × 10−7), cg16405908 (MRGPRE, p = 2.05 × 10−8), and cg07428101 (MUC2, p = 5.02 × 10−9) were associated with post-bronchodilator forced vital capacity (FVC), and cg20515679 (KCNJ6) with post-bronchodilator Tiffeneau–Pinelli index (p = 1.13 × 10−8). However, these markers did not show significant associations in publicly available data from Europeans (p > 0.05). A methylation quantitative trait loci analysis revealed that methylation levels at these CpG sites were regulated by genetic variation in Latinos and the Biobank-based Integrative Omics Studies (BIOS) consortium. Additionally, two differentially methylated regions in REXOC and AURKC were associated with pre-bronchodilator Tiffeneau–Pinelli index (adjusted p < 0.05) in Puerto Ricans and Mexican Americans. Moreover, we replicated some of the previous differentially methylated signals associated with lung function in non-Latino populations. Conclusions We replicated previous associations of epigenetic markers with lung function in whole blood and identified novel population-specific associations shared among Latino subgroups.

1337-P: Prediction of Insulin Sensitivity Using Serum Carotenoid Concentrations and Pediatric Metabolic Index in Mexican-American Children

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1337-P
Author(s):  
SRINIVAS MUMMIDI ◽  
JOSELIN HERNANDEZ-RUIZ ◽  
VIDYA S. FAROOK ◽  
LAVANYA REDDIVARI ◽  
ALVARO DIAZ-BADILLO ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Mexican American ◽  
Metabolic Index ◽  
American Children

2093-P: Acanthosis Nigricans as a Composite Marker of Cardiometabolic Risk and Its Complex Association with Obesity and Insulin Resistance in Mexican-American Children

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2093-P
Author(s):  
JUAN C. LOPEZ-ALVARENGA ◽  
RECTOR ARYA ◽  
GEETHA CHITTOOR ◽  
SOLOMON FRANKLIN PAUL ◽  
SOBHA R. PUPPALA ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Mexican American ◽  
Acanthosis Nigricans ◽  
Cardiometabolic Risk ◽  
American Children

scholarly journals Associations among phthalate exposure, DNA methylation of TSLP, and childhood allergy

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Wan-Ru Wang ◽  
Nai-Tzu Chen ◽  
Nai-Yun Hsu ◽  
I-Ying Kuo ◽  
Hsin-Wen Chang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Methylation Level ◽  
Respiratory Symptoms ◽  
Smoking Status ◽  
Phthalate Esters ◽  
Allergic Diseases ◽  
Percentage Increase ◽  
Phthalate Exposure ◽  
Settled Dust ◽  
Butyl Phthalate

Abstract Background Dysregulation of thymic stromal lymphopoietin (TSLP) expressions is linked to asthma and allergic disease. Exposure to phthalate esters, a widely used plasticizer, is associated with respiratory and allergic morbidity. Dibutyl phthalate (DBP) causes TSLP upregulation in the skin. In addition, phthalate exposure is associated with changes in environmentally induced DNA methylation, which might cause phenotypic heterogeneity. This study examined the DNA methylation of the TSLP gene to determine the potential mechanism between phthalate exposure and allergic diseases. Results Among all evaluated, only benzyl butyl phthalate (BBzP) in the settled dusts were negatively correlated with the methylation levels of TSLP and positively associated with children’s respiratory symptoms. The results revealed that every unit increase in BBzP concentration in the settled dust was associated with a 1.75% decrease in the methylation level on upstream 775 bp from the transcription start site (TSS) of TSLP (β =  − 1.75, p = 0.015) after adjustment for child’s sex, age, BMI, parents’ smoking status, allergic history, and education levels, PM2.5, formaldehyde, temperature; and relative humidity. Moreover, every percentage increase in the methylation level was associated with a 20% decrease in the risk of morning respiratory symptoms in the children (OR 0.80, 95% CI 0.65–0.99). Conclusions Exposure to BBzP in settled dust might increase children’s respiratory symptoms in the morning through decreasing TSLP methylation. Therefore, the exposure to BBzP should be reduced especially for the children already having allergic diseases.

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