scholarly journals PON1 DNA methylation and neurobehavior in Mexican-American children with prenatal organophosphate exposure

2018 ◽  
Vol 121 ◽  
pp. 31-40 ◽  
Author(s):  
Karen Huen ◽  
Olivia Solomon ◽  
Katherine Kogut ◽  
Brenda Eskenazi ◽  
Nina Holland
Keyword(s):  
Dna Methylation ◽  
Mexican American ◽  
American Children

scholarly journals DNA methylation of LINE-1 and Alu repetitive elements in relation to sex hormones and pubertal timing in Mexican-American children

2016 ◽  
Vol 79 (6) ◽  
pp. 855-862 ◽  
Author(s):  
Karen Huen ◽  
Kim Harley ◽  
Katherine Kogut ◽  
Stephen Rauch ◽  
Brenda Eskenazi ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Sex Hormones ◽  
Mexican American ◽  
Pubertal Timing ◽  
Repetitive Elements ◽  
American Children

scholarly journals Epigenome-wide association study of lung function in Latino children and youth with asthma

2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Esther Herrera-Luis ◽  
Annie Li ◽  
Angel C. Y. Mak ◽  
Javier Perez-Garcia ◽  
Jennifer R. Elhawary ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Lung Function ◽  
Association Study ◽  
Whole Blood ◽  
Mexican Americans ◽  
Mexican American ◽  
Puerto Ricans ◽  
Cpg Sites ◽  
Significance Threshold ◽  
American Children

Abstract Introduction DNA methylation studies have associated methylation levels at different CpG sites or genomic regions with lung function. Moreover, genetic ancestry has been associated with lung function in Latinos. However, no epigenome-wide association study (EWAS) of lung function has been performed in this population. Here, we aimed to identify DNA methylation patterns associated with lung function in pediatric asthma among Latinos. Results We conducted an EWAS in whole blood from 250 Puerto Rican and 148 Mexican American children and young adults with asthma. A total of five CpGs exceeded the genome-wide significance threshold of p = 1.17 × 10−7 in the combined analyses from Puerto Ricans and Mexican Americans: cg06035600 (MAP3K6, p = 6.13 × 10−8) showed significant association with pre-bronchodilator Tiffeneau–Pinelli index, the probes cg00914963 (TBC1D16, p = 1.04 × 10−7), cg16405908 (MRGPRE, p = 2.05 × 10−8), and cg07428101 (MUC2, p = 5.02 × 10−9) were associated with post-bronchodilator forced vital capacity (FVC), and cg20515679 (KCNJ6) with post-bronchodilator Tiffeneau–Pinelli index (p = 1.13 × 10−8). However, these markers did not show significant associations in publicly available data from Europeans (p > 0.05). A methylation quantitative trait loci analysis revealed that methylation levels at these CpG sites were regulated by genetic variation in Latinos and the Biobank-based Integrative Omics Studies (BIOS) consortium. Additionally, two differentially methylated regions in REXOC and AURKC were associated with pre-bronchodilator Tiffeneau–Pinelli index (adjusted p < 0.05) in Puerto Ricans and Mexican Americans. Moreover, we replicated some of the previous differentially methylated signals associated with lung function in non-Latino populations. Conclusions We replicated previous associations of epigenetic markers with lung function in whole blood and identified novel population-specific associations shared among Latino subgroups.

1337-P: Prediction of Insulin Sensitivity Using Serum Carotenoid Concentrations and Pediatric Metabolic Index in Mexican-American Children

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1337-P
Author(s):  
SRINIVAS MUMMIDI ◽  
JOSELIN HERNANDEZ-RUIZ ◽  
VIDYA S. FAROOK ◽  
LAVANYA REDDIVARI ◽  
ALVARO DIAZ-BADILLO ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Mexican American ◽  
Metabolic Index ◽  
American Children

2093-P: Acanthosis Nigricans as a Composite Marker of Cardiometabolic Risk and Its Complex Association with Obesity and Insulin Resistance in Mexican-American Children

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2093-P
Author(s):  
JUAN C. LOPEZ-ALVARENGA ◽  
RECTOR ARYA ◽  
GEETHA CHITTOOR ◽  
SOLOMON FRANKLIN PAUL ◽  
SOBHA R. PUPPALA ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Mexican American ◽  
Acanthosis Nigricans ◽  
Cardiometabolic Risk ◽  
American Children
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