Early life exposure to ambient air pollution and childhood asthma in China

2015 ◽  
Vol 143 ◽  
pp. 83-92 ◽  
Author(s):  
Qihong Deng ◽  
Chan Lu ◽  
Dan Norbäck ◽  
Carl-Gustaf Bornehag ◽  
Yinping Zhang ◽  
...  
Keyword(s):  
Air Pollution ◽  
Childhood Asthma ◽  
Early Life ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Early Life Exposure

scholarly journals Early life exposure to air pollution induces adult cardiac dysfunction

2014 ◽  
Vol 307 (9) ◽  
pp. H1353-H1360 ◽  
Author(s):  
Matthew W. Gorr ◽  
Markus Velten ◽  
Timothy D. Nelin ◽  
Dane J. Youtz ◽  
Qinghua Sun ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cardiac Dysfunction ◽  
Early Life ◽  
Ambient Air ◽  
Left Ventricular ◽  
Average Concentration ◽  
Ambient Air Pollution ◽  
Adrenergic Stimulation ◽  
Reduced Ejection Fraction ◽  
Early Life Exposure

Exposure to ambient air pollution contributes to the progression of cardiovascular disease, particularly in susceptible populations. The objective of the present study was to determine whether early life exposure to air pollution causes persistent cardiovascular consequences measured at adulthood. Pregnant FVB mice were exposed to filtered (FA) or concentrated ambient particulate matter (PM2.5) during gestation and nursing. Mice were exposed to PM2.5at an average concentration of 51.69 μg/m3from the Columbus, OH region for 6 h/day, 7 days/wk in utero until weaning at 3 wk of age. Birth weight was reduced in PM2.5pups compared with FA (1.36 ± 0.12 g FA, n = 42 mice; 1.30 ± 0.15 g PM2.5, n = 67 P = 0.012). At adulthood, mice exposed to perinatal PM2.5had reduced left ventricular fractional shortening compared with FA-exposed mice (43.6 ± 2.1% FA, 33.2 ± 1.6% PM2.5, P = 0.001) with greater left ventricular end systolic diameter. Pressure-volume loops showed reduced ejection fraction (79.1 ± 3.5% FA, 35.5 ± 9.5% PM2.5, P = 0.005), increased end-systolic volume (10.4 ± 2.5 μl FA, 39.5 ± 3.8 μl PM2.5, P = 0.001), and reduced dP/d t maximum (11,605 ± 200 μl/s FA, 9,569 ± 800 μl/s PM2.5, P = 0.05) and minimum (−9,203 ± 235 μl/s FA, −7,045 ± 189 μl/s PM2.5, P = 0.0005) in PM2.5-exposed mice. Isolated cardiomyocytes from the hearts of PM2.5-exposed mice had reduced peak shortening (%PS, 8.53 ± 2.82% FA, 6.82 ± 2.04% PM2.5, P = 0.003), slower calcium reuptake (τ, 0.22 ± 0.09 s FA, 0.26 ± 0.07 s PM2.5, P = 0.048), and reduced response to β-adrenergic stimulation compared with cardiomyocytes isolated from mice that were exposed to FA. Histological analyses revealed greater picro-sirius red-positive-stained areas in the PM2.5vs. FA group, indicative of increased collagen deposition. We concluded that these data demonstrate the detrimental role of early life exposure to ambient particulate air pollution in programming of adult cardiovascular diseases and the potential for PM2.5to induce persistent cardiac dysfunction at adulthood.

Effects of ambient air pollution on childhood asthma exacerbation in the Philadelphia metropolitan Region, 2011–2014

2021 ◽  
Vol 197 ◽  
pp. 110955
Author(s):  
Wanyu Huang ◽  
Leah H. Schinasi ◽  
Chén C. Kenyon ◽  
Kari Moore ◽  
Steven Melly ◽  
...  
Keyword(s):  
Air Pollution ◽  
Childhood Asthma ◽  
Asthma Exacerbation ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Metropolitan Region

scholarly journals Prenatal and early life exposures to ambient air pollution and development

2019 ◽  
Vol 174 ◽  
pp. 170-175 ◽  
Author(s):  
Sandie Ha ◽  
Edwina Yeung ◽  
Erin Bell ◽  
Tabassum Insaf ◽  
Akhgar Ghassabian ◽  
...  
Keyword(s):  
Air Pollution ◽  
Early Life ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Early Life Exposures

scholarly journals Effect of Early Life Exposure to Air Pollution on Development of Childhood Asthma

2010 ◽  
Vol 118 (2) ◽  
pp. 284-290 ◽  
Author(s):  
Nina Annika Clark ◽  
Paul A. Demers ◽  
Catherine J. Karr ◽  
Mieke Koehoorn ◽  
Cornel Lencar ◽  
...  
Keyword(s):  
Air Pollution ◽  
Childhood Asthma ◽  
Early Life ◽  
Early Life Exposure

scholarly journals Satellite-based Estimates of Ambient Air Pollution and Global Variations in Childhood Asthma Prevalence

2012 ◽  
Vol 120 (9) ◽  
pp. 1333-1339 ◽  
Author(s):  
H. Ross Anderson ◽  
Barbara K. Butland ◽  
Aaron van Donkelaar ◽  
Michael Brauer ◽  
David P. Strachan ◽  
...  
Keyword(s):  
Air Pollution ◽  
Childhood Asthma ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Asthma Prevalence

Changes in the relationship between childhood asthma and ambient air pollution in Taiwan: Results from a nationwide survey repeated 5 years apart

2018 ◽  
Vol 30 (2) ◽  
pp. 188-194 ◽  
Author(s):  
Bing-Yu Chen ◽  
Chi-Hsien Chen ◽  
Yu-Chen Chuang ◽  
Ying-Hsuan Wu ◽  
Shih-Chun Pan ◽  
...  
Keyword(s):  
Air Pollution ◽  
Childhood Asthma ◽  
Nationwide Survey ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
The Relationship
Sign in / Sign up

Export Citation Format

Share Document