scholarly journals Tropical Geometries and Dynamics of Biochemical Networks Application to Hybrid Cell Cycle Models

2012 ◽  
Vol 284 ◽  
pp. 75-91 ◽  
Author(s):  
Vincent Noel ◽  
Dima Grigoriev ◽  
Sergei Vakulenko ◽  
Ovidiu Radulescu
Keyword(s):  
Cell Cycle ◽  
Hybrid Cell ◽  
Biochemical Networks ◽  
Cell Cycle Models

Limitations of cell kinetics in distinguishing cell cycle models

Nature ◽  
1981 ◽  
Vol 293 (5834) ◽  
pp. 648-650 ◽  
Author(s):  
J. A. Smith ◽  
D. J. R. Laurence ◽  
P. S. Rudland
Keyword(s):  
Cell Cycle ◽  
Cell Kinetics ◽  
Cell Cycle Models

Identification of Cell Cycle Models by Flow Cytometry

1994 ◽  
Vol 27 (1) ◽  
pp. 421-422
Author(s):  
Lorenzo Cazzador ◽  
Luigi Mariani
Keyword(s):  
Cell Cycle ◽  
Flow Cytometry ◽  
Cell Cycle Models

Cell cycle models and mother-daughter correlation

1988 ◽  
Vol 131 (2) ◽  
pp. 255-262 ◽  
Author(s):  
Gilles Hejblum ◽  
Dominique Costagliola ◽  
Alain-Jacques Valleron ◽  
Jean-Yves Mary
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Models

Age-dependent Cell Cycle Models

2001 ◽  
Vol 213 (1) ◽  
pp. 89-101 ◽  
Author(s):  
JOANNA TYRCHA
Keyword(s):  
Cell Cycle ◽  
Age Dependent ◽  
Dependent Cell ◽  
Cell Cycle Models

Cotargeting signaling pathways driving survival and cell cycle circumvents resistance to Kit inhibitors in leukemia

Blood ◽  
2012 ◽  
Vol 119 (18) ◽  
pp. 4228-4241 ◽  
Author(s):  
Dorothée Buet ◽  
Isabelle Gallais ◽  
Evelyne Lauret ◽  
Nicole Denis ◽  
Bérangère Lombard ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Targeted Therapy ◽  
Signaling Pathways ◽  
Synergistic Effects ◽  
Leukemia Cell ◽  
Biochemical Networks ◽  
Mass Spectrometry Analysis ◽  
Leukemia Cell Line ◽  
Signaling Networks ◽  
Spectrometry Analysis

Abstract Oncogenic mutations leading to persistent kinase activities are associated with malignancies. Therefore, deciphering the signaling networks downstream of these oncogenic stimuli remains a challenge to gather insights into targeted therapy. To elucidate the biochemical networks connecting the Kit mutant to leukemogenesis, in the present study, we performed a global profiling of tyrosine-phosphorylated proteins from mutant Kit-driven murine leukemia proerythroblasts and identified Shp2 and Stat5 as proximal effectors of Kit. Shp2 or Stat5 gene depletion by sh-RNA, combined with pharmacologic inhibition of PI3kinase or Mek/Erk activities, revealed 2 distinct and independent signaling pathways contributing to malignancy. We demonstrate that cell survival is driven by the Kit/Shp2/Ras/Mek/Erk1/2 pathway, whereas the G1/S transition during the cell cycle is accelerated by both the Kit/Stat5 and Kit/PI3K/Akt pathways. The combined use of the clinically relevant drugs NVP-BEZ235, which targets the cell cycle, and Obatoclax, which targets survival, demonstrated synergistic effects to inhibit leukemia cell growth. This synergy was confirmed with a human mast leukemia cell line (HMC-1.2) that expresses mutant Kit. The results of the present study using liquid chromatography/tandem mass spectrometry analysis have elucidated signaling networks downstream of an oncogenic kinase, providing a molecular rationale for pathway-targeted therapy to treat cancer cells refractory to tyrosine kinase inhibitors.

scholarly journals Novel chromosome organization pattern in actinomycetales–overlapping replication cycles combined with diploidy

2016 ◽  
Author(s):  
Kati Böhm ◽  
Fabian Meyer ◽  
Agata Rhomberg ◽  
Jörn Kalinowski ◽  
Catriona Donovan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Chromosome Segregation ◽  
Chromosome Organization ◽  
Model Species ◽  
Chromosomal Organization ◽  
Dna Segregation ◽  
Rate Dependent ◽  
Dependent Cell ◽  
Underlying Mechanisms ◽  
Cell Cycle Models

AbstractBacteria regulate chromosome replication and segregation tightly with cell division to ensure faithful segregation of DNA to daughter generations. The underlying mechanisms have been addressed in several model species. It became apparent that bacteria have evolved quite different strategies to regulate DNA segregation and chromosomal organization. We have investigated here how the actinobacteriumCorynebacterium glutamicumorganizes chromosome segregation and DNA replication. Unexpectedly, we find thatC. glutamicumcells are at least diploid under all conditions tested and that these organisms have overlapping C-periods during replication with both origins initiating replication simultaneously. Based on experimentally obtained data we propose growth rate dependent cell cycle models forC. glutamicum.

On the existence of the stable birth-type distribution in a general branching process cell cycle model with unequal cell division

2001 ◽  
Vol 38 (03) ◽  
pp. 685-695 ◽  
Author(s):  
Marina Alexandersson
Keyword(s):  
Cell Cycle ◽  
Branching Process ◽  
Critical Size ◽  
Birth Size ◽  
Cycle Model ◽  
Frobenius Theorem ◽  
Type Distribution ◽  
A Cell ◽  
Cell Cycle Models ◽  
Birth Type

We use multi-type branching process theory to construct a cell population model, general enough to include a large class of such models, and we use an abstract version of the Perron-Frobenius theorem to prove the existence of the stable birth-type distribution. The generality of the model implies that a stable birth-size distribution exists in most size-structured cell cycle models. By adding the assumption of a critical size that each cell has to pass before division, called the nonoverlapping case, we get an explicit analytical expression for the stable birth-type distribution.

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