Limitations of cell kinetics in distinguishing cell cycle models

Nature ◽  
1981 ◽  
Vol 293 (5834) ◽  
pp. 648-650 ◽  
Author(s):  
J. A. Smith ◽  
D. J. R. Laurence ◽  
P. S. Rudland
Keyword(s):  
Cell Cycle ◽  
Cell Kinetics ◽  
Cell Cycle Models

scholarly journals Responsiveness of Hematopoietic Tissue to Erythropoietin in Relation to the Time of Administration and Duration of Action of the Hormone

Blood ◽  
1965 ◽  
Vol 25 (5) ◽  
pp. 795-808 ◽  
Author(s):  
JOHN C. SCHOOLEY
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Stem Cell ◽  
Life Cycle ◽  
Cell Kinetics ◽  
Limited Time ◽  
Hematopoietic Tissue ◽  
Duration Of Action ◽  
Time Of Administration ◽  
Different Doses

Abstract Following the injection of erythropoietin either in a single large dose or in multiple doses, a change in the responsiveness of the hematopoietic tissue occurs. The fact that different doses of erythropoietin stimulate erythropoiesis to the same extent when the action of the hormone is limited to 6 hours by the injection of antibody suggests that the stem cells are receptive to the action of erythropoietin only at some limited time in their individual life cycle. It is suggested that this period is sometime after metaphase and before the commencement of DNA synthesis in the interphase state of individual stem cells. It is further suggested that the increased responsiveness of the hematopoietic tissue to erythropoietin following injection is due to recruitment of stem cells into this receptive state. This recruitment may be due to both the division of stem cells and the movement of cells through cell cycle into the receptive state. The results are discussed in relation to two recent models of stem cell kinetics.

Identification of Cell Cycle Models by Flow Cytometry

1994 ◽  
Vol 27 (1) ◽  
pp. 421-422
Author(s):  
Lorenzo Cazzador ◽  
Luigi Mariani
Keyword(s):  
Cell Cycle ◽  
Flow Cytometry ◽  
Cell Cycle Models

Cell cycle models and mother-daughter correlation

1988 ◽  
Vol 131 (2) ◽  
pp. 255-262 ◽  
Author(s):  
Gilles Hejblum ◽  
Dominique Costagliola ◽  
Alain-Jacques Valleron ◽  
Jean-Yves Mary
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Models

Age-dependent Cell Cycle Models

2001 ◽  
Vol 213 (1) ◽  
pp. 89-101 ◽  
Author(s):  
JOANNA TYRCHA
Keyword(s):  
Cell Cycle ◽  
Age Dependent ◽  
Dependent Cell ◽  
Cell Cycle Models

scholarly journals Novel chromosome organization pattern in actinomycetales–overlapping replication cycles combined with diploidy

2016 ◽  
Author(s):  
Kati Böhm ◽  
Fabian Meyer ◽  
Agata Rhomberg ◽  
Jörn Kalinowski ◽  
Catriona Donovan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Chromosome Segregation ◽  
Chromosome Organization ◽  
Model Species ◽  
Chromosomal Organization ◽  
Dna Segregation ◽  
Rate Dependent ◽  
Dependent Cell ◽  
Underlying Mechanisms ◽  
Cell Cycle Models

AbstractBacteria regulate chromosome replication and segregation tightly with cell division to ensure faithful segregation of DNA to daughter generations. The underlying mechanisms have been addressed in several model species. It became apparent that bacteria have evolved quite different strategies to regulate DNA segregation and chromosomal organization. We have investigated here how the actinobacteriumCorynebacterium glutamicumorganizes chromosome segregation and DNA replication. Unexpectedly, we find thatC. glutamicumcells are at least diploid under all conditions tested and that these organisms have overlapping C-periods during replication with both origins initiating replication simultaneously. Based on experimentally obtained data we propose growth rate dependent cell cycle models forC. glutamicum.

On the existence of the stable birth-type distribution in a general branching process cell cycle model with unequal cell division

2001 ◽  
Vol 38 (03) ◽  
pp. 685-695 ◽  
Author(s):  
Marina Alexandersson
Keyword(s):  
Cell Cycle ◽  
Branching Process ◽  
Critical Size ◽  
Birth Size ◽  
Cycle Model ◽  
Frobenius Theorem ◽  
Type Distribution ◽  
A Cell ◽  
Cell Cycle Models ◽  
Birth Type

We use multi-type branching process theory to construct a cell population model, general enough to include a large class of such models, and we use an abstract version of the Perron-Frobenius theorem to prove the existence of the stable birth-type distribution. The generality of the model implies that a stable birth-size distribution exists in most size-structured cell cycle models. By adding the assumption of a critical size that each cell has to pass before division, called the nonoverlapping case, we get an explicit analytical expression for the stable birth-type distribution.

Differential mitosis and degeneration patterns in relation to the alterations in the shape of the embryonic ectoderm of early post-implantation mouse embryos

Development ◽  
1980 ◽  
Vol 55 (1) ◽  
pp. 33-51
Author(s):  
R. E. Poelmann
Keyword(s):  
Cell Cycle ◽  
Cell Kinetics ◽  
Tritiated Thymidine ◽  
Primitive Streak ◽  
Cell Number ◽  
Mouse Embryos ◽  
Surface Ectoderm ◽  
Dividing Cells ◽  
Post Implantation ◽  
Embryonic Ectoderm

The shape of the embryonic ectoderm of early post-implantation mouse embryos changes greatly in the period of 6·2–7·3 days post coitum. The subcellular morphology of the embryonic ectoderm remains unchanged, except in the primitive-streak region. Cell kinetics differ between ectodermal regions. These differences may be related to the changes in the shape of the ectoderm. The increase in cell number in the lateral ectoderm (the prospective surface ectoderm) exceeds that in the frontal ectoderm (the future neurectoderm). This is not due to differences in the duration of the cell cycle. It can be explained, however, by the occurrence of different relative numbers of dividing and non-dividing cells. These numbers vary between the two regions. The percentage of non-dividing cells in the frontal ectoderm may reach 45, whereas in the lateral ectoderm this percentage is not higher than 15. Autoradiography in tritiated thymidine-treated embryos combined with the mitotic indices gave us all of the parameters necessary to present a model capable of clarifying the growth of the ectoderm during gastrulation, as well as the changes in the shape of the ectoderm.

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