scholarly journals RNAIII-inhibiting Peptide and/or Nisin Inhibit Experimental Vascular Graft Infection with Methicillin-susceptible and Methicillin-resistant Staphylococcus epidermidis

2004 ◽  
Vol 27 (6) ◽  
pp. 603-607 ◽  
Author(s):  
R Ghiselli ◽  
A Giacometti ◽  
O Cirioni ◽  
G Dell'Acqua ◽  
F Mocchegiani ◽  
...  
Keyword(s):  
Staphylococcus Epidermidis ◽  
Vascular Graft ◽  
Graft Infection ◽  
Vascular Graft Infection ◽  
Methicillin Resistant

scholarly journals Temporin A Soaking in Combination with Intraperitoneal Linezolid Prevents Vascular Graft Infection in a Subcutaneous Rat Pouch Model of Infection with Staphylococcus epidermidis with Intermediate Resistance to Glycopeptides

2004 ◽  
Vol 48 (8) ◽  
pp. 3162-3164 ◽  
Author(s):  
Andrea Giacometti ◽  
Oscar Cirioni ◽  
Roberto Ghiselli ◽  
Fiorenza Orlando ◽  
Giuseppina D'Amato ◽  
...  
Keyword(s):  
Staphylococcus Epidermidis ◽  
Vascular Graft ◽  
Graft Infection ◽  
Prosthetic Graft ◽  
Vascular Graft Infection ◽  
Methicillin Resistant ◽  
Prosthetic Graft Infection ◽  
Intermediate Resistance ◽  
Temporin A

ABSTRACT The efficacy of linezolid and temporin A in the prevention of prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides was investigated in a subcutaneous rat pouch model. Linezolid and temporin A, alone or combined, greatly reduced the bacterial numbers compared to the effect with control drugs.

Risk factors for methicillin-resistant staphylococcal vascular graft infection in an 11-year cohort study

2012 ◽  
Vol 64 (4) ◽  
pp. 441-444 ◽  
Author(s):  
Laurence Legout ◽  
Piervito D’Elia ◽  
Patrick Devos ◽  
Nicolas Ettahar ◽  
Beatrice Sarraz-Bournet ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Vascular Graft ◽  
Graft Infection ◽  
Vascular Graft Infection ◽  
Methicillin Resistant

Experimental Treatment of Vascular Graft Infection due to Staphylococcus epidermidis by In Situ Replacement with a Rifampin-bonded Polyester Graft

2001 ◽  
Vol 15 (4) ◽  
pp. 421-429 ◽  
Author(s):  
Marc Coggia ◽  
Olivier Goëau-Brissonnière ◽  
Véronique Leflon ◽  
Marie-Hélène Nicolas ◽  
Jean-Claude Pechère
Keyword(s):  
Staphylococcus Epidermidis ◽  
Vascular Graft ◽  
Graft Infection ◽  
Experimental Treatment ◽  
Vascular Graft Infection ◽  
In Situ Replacement

scholarly journals Polycationic Peptides as Prophylactic Agents against Methicillin-Susceptible or Methicillin-Resistant Staphylococcus epidermidis Vascular Graft Infection

2000 ◽  
Vol 44 (12) ◽  
pp. 3306-3309 ◽  
Author(s):  
Andrea Giacometti ◽  
Oscar Cirioni ◽  
Roberto Ghiselli ◽  
Luigi Goffi ◽  
Federico Mocchegiani ◽  
...  
Keyword(s):  
Rat Model ◽  
Staphylococcus Epidermidis ◽  
Subcutaneous Tissue ◽  
Bacterial Species ◽  
Graft Infection ◽  
Prosthetic Graft ◽  
Control Group ◽  
Vascular Graft Infection ◽  
Agar Culture ◽  
Methicillin Resistant

ABSTRACT Several polycationic peptides isolated from animals, plants, and bacterial species possess a broad spectrum of antimicrobial activity. A rat model was used to investigate the efficacies of two peptides, ranalexin and buforin II, in the prevention of vascular prosthetic graft infections. The effect of peptide-soaked collagen-sealed Dacron was compared to that of rifampin-soaked collagen-sealed Dacron in the rat model of graft infection caused by methicillin-susceptible rifampin-susceptible Staphylococcus epidermidis and methicillin-resistant rifampin-susceptible S. epidermidis. Graft infections were established in the back subcutaneous tissue of 240 adult male Wistar rats by implantation of 1-cm2 Dacron prostheses, followed by topical inoculation with 2 × 107 CFU of S. epidermidis. The study included a control group (no graft contamination), two contaminated groups that did not receive any antibiotic prophylaxis, two contaminated groups to which perioperative intraperitoneal cefazolin prophylaxis (30 mg/kg of body weight) was administered, six contaminated groups that received a peptide- or rifampin-soaked graft, and six contaminated groups that received a peptide- or rifampin-soaked graft and perioperative intraperitoneal cefazolin prophylaxis (30 mg/kg). The grafts were sterilely removed 7 days after implantation, and the infection was evaluated by using sonication and quantitative agar culture. Overall, the efficacies of the polycationic peptides against the methicillin-susceptible and methicillin-resistant strains were not significantly different from that of rifampin. Nevertheless, the combinations of ranalexin- and buforin II-coated grafts with cefazolin treatment demonstrated efficacies significantly higher than that of the combination of rifampin-coated grafts and cefazolin treatment against the methicillin-resistant strain.

Dalbavancin as a second-line treatment in methicillin-resistant Staphylococcus aureus prosthetic vascular graft infection

Infection ◽  
2019 ◽  
Vol 48 (2) ◽  
pp. 309-310 ◽  
Author(s):  
Arturo Ciccullo ◽  
Gabriele Giuliano ◽  
Francesco Vladimiro Segala ◽  
Eleonora Taddei ◽  
Damiano Farinacci ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Vascular Graft ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Graft Infection ◽  
Line Treatment ◽  
Second Line ◽  
Vascular Graft Infection ◽  
Methicillin Resistant ◽  
Prosthetic Vascular Graft Infection
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