Prognostic factors and recurrence pattern in node-negative advanced gastric cancer

2013 ◽  
Vol 39 (2) ◽  
pp. 136-140 ◽  
Author(s):  
I.S. Lee ◽  
J.H. Yook ◽  
T.H. Kim ◽  
H.S. Kim ◽  
K.C. Kim ◽  
...  
2017 ◽  
Vol 23 (45) ◽  
pp. 8000-8007 ◽  
Author(s):  
Gian Luca Baiocchi ◽  
Sarah Molfino ◽  
Carla Baronchelli ◽  
Simone Giacopuzzi ◽  
Daniele Marrelli ◽  
...  

2017 ◽  
Vol 28 ◽  
pp. iii51
Author(s):  
Beatriz Caldeira ◽  
Hugo Santos-Sousa ◽  
Mariana Fernandes ◽  
Bárbara Castro ◽  
Vítor Devezas ◽  
...  

2019 ◽  
Vol 45 (2) ◽  
pp. e77
Author(s):  
E. Martins ◽  
H. Santos-Sousa ◽  
J. Nogueiro ◽  
J. Barbosa ◽  
J. Costa-Maia

2010 ◽  
Vol 101 (7) ◽  
pp. 622-625 ◽  
Author(s):  
Hiroaki Saito ◽  
Hirohiko Kuroda ◽  
Tomoyuki Matsunaga ◽  
Kenji Fukuda ◽  
Shigeru Tatebe ◽  
...  

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Shanshan Yang ◽  
Xinjia He ◽  
Ying Liu ◽  
Xiao Ding ◽  
Haiping Jiang ◽  
...  

Purpose. In this study, we aim to evaluate the prognostic role of serum uric acid and gamma-glutamyltransferase in advanced gastric cancer patients. Methods. A total of 180 patients pathologically diagnosed with advanced gastric cancer were included in this retrospective study. We used time-dependent receiver operating characteristic (ROC) curves to identify the optimal cut-off value of serum uric acid (UA) and gamma-glutamyltransferase (GGT). Survival analysis was performed using the Kaplan–Meier method and log-rank test, and multivariate Cox regression analyses were applied. A nomogram was formulated, and the calibration and discrimination of the nomogram were determined by calibration curve and concordance index (C-index). We validated the results using bootstrap resampling and a separate study on 60 patients collected from 2015 to 2017 using the same criteria in other medical center. Results. Both higher serum uric acid (>228 μmol/L) and higher gamma-glutamyltransferase (>14 U/L) had worse OS and PFS. Univariate analysis indicated that serum uric acid (UA) (p<0.001 and p<0.001) and gamma-glutamyltransferase (GGT) (p<0.001 and p=0.044) were significantly related to overall survival (OS) and progression-free survival (PFS), respectively. Multivariate analysis revealed serum uric acid (UA) and gamma-glutamyltransferase (GGT) were independent prognostic factors for OS (p=0.012, p=0.001). The optimal agreement between actual observation and nomogram prediction was shown by calibration curves. The C-indexes of the nomogram for predicting OS and PFS were 0.748 (95% CI: 0.70-0.79) and 0.728 (95% CI: 0.6741-0.7819), respectively. The results were confirmed in the validation cohort. Conclusion. We observed that both serum UA and GGT were poor prognostic factors in patients with advanced gastric cancer. And we also formulated and validated a nomogram which can predict individual survival for advanced gastric cancer patients.


2002 ◽  
Vol 9 (6) ◽  
pp. 562-567 ◽  
Author(s):  
Woo Jin Hyung ◽  
Jun Ho Lee ◽  
Seung Ho Choi ◽  
Jin Sik Min ◽  
Sung Hoon Noh

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