Carboplatin loaded Surface modified PLGA nanoparticles: Optimization, characterization, and in vivo brain targeting studies

2016 ◽  
Vol 142 ◽  
pp. 307-314 ◽  
Author(s):  
S. Jose ◽  
B.C. Juna ◽  
T.A. Cinu ◽  
H. Jyoti ◽  
N.A. Aleykutty
Keyword(s):  
Plga Nanoparticles ◽  
Brain Targeting ◽  
Loaded Surface ◽  
Surface Modified

Revaprazan-loaded surface-modified solid dispersion: physicochemical characterization and in vivo evaluation

2019 ◽  
Vol 24 (6) ◽  
pp. 788-793 ◽  
Author(s):  
Jong Hyuck Park ◽  
Jung Hyun Cho ◽  
Dong Shik Kim ◽  
Jung Suk Kim ◽  
Fakhar Ud Din ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Physicochemical Characterization ◽  
In Vivo Evaluation ◽  
Loaded Surface ◽  
Surface Modified

scholarly journals Toxicity, pharmacokinetics, and in vivo efficacy of biotinylated chitosan surface-modified PLGA nanoparticles for tumor therapy

2016 ◽  
Vol 45 (6) ◽  
pp. 1115-1122 ◽  
Author(s):  
Hongli Chen ◽  
WenBin Nan ◽  
Xiangjuan Wei ◽  
Yan Wang ◽  
Feng Lv ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Plga Nanoparticles ◽  
In Vivo Efficacy ◽  
Surface Modified

PLGA nanoparticles for nose to brain delivery of Clonazepam: formulation, optimization by 32 Factorial design, in vitro and in vivo evaluation

2020 ◽  
Vol 17 ◽  
Author(s):  
Pranav Shah ◽  
Jayant Sarolia ◽  
Bhavin Vyas ◽  
Priti Wagh ◽  
Kaul Ankur ◽  
...  
Keyword(s):  
Particle Size ◽  
Factorial Design ◽  
Intranasal Administration ◽  
Plga Nanoparticles ◽  
Brain Targeting ◽  
Rabbit Brain ◽  
Histopathological Study ◽  
In Vivo Evaluation

Background: Intranasal administration of biodegradable nanoparticles has been extensively studied for targeting the drug directly to CNS through olfactory or trigeminal route bypassing blood brain barrier. Objective: The objective of the present study was to optimize Clonazepam loaded PLGA nanoparticles (CLO-PNPs) by investigating the effect of process variables on the responses using 32 full factorial design. Methods: Effect of two independent factors-amount of PLGA and concentration of Poloxamer 188, were studied at low, medium and high levels on three dependent responses-%Entrapment efficiency, Particle size (nm) and %cumulative drug release at 24hr. Results: %EE, Particle size and %CDR at 24hr of optimized batch was 63.7%, 165.1 nm and 86.96% respectively. Nanoparticles were radiolabeled with 99mTc and biodistribution was investigated in BALB/c mice after intranasal & intravenous administrations. Significantly higher brain/blood uptake ratios and AUC values in brain following intranasal administration of CLO-PNPs indicated more effective brain targeting of CLO. Higher brain uptake of intranasal CLO-PNPs was confirmed by rabbit brain scintigraphy imaging. Histopathological study performed on goat nasal mucosa revealed no adverse response of nanoparticles. TEM image exhibited spherical shaped particles in nano range. DSC and XRD studies suggested Clonazepam encapsulation within PLGA matrix. The onset of occurrence of PTZ-induced seizures in rats was significantly delayed by intranasal nanoparticles as compared to intranasal & intravenous CLO-SOL. Conclusion: This investigation exhibits rapid rate and higher extent of CLO transport in brain with intranasal CLO-PNPs suggesting a better option as compared to oral & parenteral route in management of acute status epilepticus.

Surface modified PLGA nanoparticles for brain targeting of Bacoside-A

2014 ◽  
Vol 63 ◽  
pp. 29-35 ◽  
Author(s):  
S. Jose ◽  
S. Sowmya ◽  
T.A. Cinu ◽  
N.A. Aleykutty ◽  
S. Thomas ◽  
...  
Keyword(s):  
Plga Nanoparticles ◽  
Brain Targeting ◽  
Bacoside A ◽  
Surface Modified

scholarly journals Ligand Decorated Embelin Loaded PLGA Nanoparticles for Management of Alcohol Induced Hepatotoxicity

2020 ◽  
Vol 10 (1) ◽  
pp. 72-80
Author(s):  
Ajay Kumar ◽  
M. Nikhat Khan ◽  
Jovita Kanoujia ◽  
Amandeep Singh ◽  
Neeraj Mishra
Keyword(s):  
High Performance ◽  
In Vitro Release ◽  
Plga Nanoparticles ◽  
Hep G2 ◽  
Release Studies ◽  
Plga Nanoparticle ◽  
Surface Modified ◽  
Vitro Release

Preparation of surface modified Embelin loaded nanoparticles (GA-PEG-PLGA) for the management of hepatotoxicity. Surface modified Embelin loaded GA-PEG-PLGA NPs were evaluated by NMR, FTIR, TEM techniques and in vitro release studies. The biodistribution of the nanoparticles was assessed by High-performance liquid chromatography (HPLC), and the cellular uptake study was evaluated using Hep G2 cells (liver cells lines). The hepatoprotecttive effect of the surface modified Embelin loaded GA-PEG-PLGA NPs was investigated in-vitro and in-vivo. The surface modified Embelin loaded GA-PEG-PLGA nanoparticles significantly increases the uptake of drug in liver by 2.5 folds more than plain drug. Keywords: Glycyrrhetinic acid, Receptor mediated, Surface functionalization, Embelin, PLGA nanoparticle.

scholarly journals Clopidogrel Napadisilate Monohydrate Loaded Surface-Modified Solid Dispersion: Physicochemical Characterization and in Vivo Evaluation

2015 ◽  
Vol 38 (7) ◽  
pp. 1033-1040 ◽  
Author(s):  
Young Hun Kim ◽  
Dong Wuk Kim ◽  
Min Seok Kwon ◽  
Kwan Hyung Cho ◽  
Jong Oh Kim ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Physicochemical Characterization ◽  
Loaded Surface ◽  
Surface Modified

Targeting liver cancer via ASGP receptor using 5-FU-loaded surface-modified PLGA nanoparticles

2014 ◽  
Vol 31 (5) ◽  
pp. 479-487 ◽  
Author(s):  
Ruchi Dangi ◽  
Pooja Hurkat ◽  
Ankit Jain ◽  
Satish Shilpi ◽  
Ashish Jain ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Plga Nanoparticles ◽  
Loaded Surface ◽  
Surface Modified
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