Chitosan coated sodium alginate–chitosan nanoparticles loaded with 5-FU for ocular delivery: In vitro characterization and in vivo study in rabbit eye

2012 ◽  
Vol 47 (4) ◽  
pp. 678-685 ◽  
Author(s):  
Ramesh C. Nagarwal ◽  
Rakesh Kumar ◽  
J.K. Pandit
Keyword(s):  
Sodium Alginate ◽  
Chitosan Nanoparticles ◽  
In Vivo Study ◽  
Ocular Delivery ◽  
Rabbit Eye ◽  
In Vitro Characterization

scholarly journals Fabrication of Transgelosomes for Enhancing the Ocular Delivery of Acetazolamide: Statistical Optimization, In Vitro Characterization, and In Vivo Study

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 465 ◽  
Author(s):  
Eman A. Mazyed ◽  
Abdelaziz E. Abdelaziz
Keyword(s):  
Ex Vivo ◽  
Entrapment Efficiency ◽  
Tween 80 ◽  
Ocular Delivery ◽  
Ethanol Injection ◽  
In Vitro Characterization ◽  
Span 60 ◽  
In Vivo Characterization

Acetazolamide (ACZ) is a potent carbonic anhydrase inhibitor that is used for the treatment of glaucoma. Its oral administration causes various undesirable side effects. This study aimed to formulate transgelosomes (TGS) for enhancing the ocular delivery of ACZ. ACZ-loaded transfersomes were formulated by the ethanol injection method, using phosphatidylcholine (PC) and different edge activators, including Tween 80, Span 60, and Cremophor RH 40. The effects of the ratio of lipid to surfactant and type of surfactant on % drug released after 8 h (Q8h) and entrapment efficiency (EE%) were investigated by using Design-Expert software. The optimized formula was formulated as TGS, using poloxamers as gelling agents. In vitro and in vivo characterization of ACZ-loaded TGS was performed. According to optimization study, F8 had the highest desirability value and was chosen as the optimized formula for preparing TGS. F8 appeared as spherical elastic nanovesicles with Q8h of 93.01 ± 3.76% and EE% of 84.44 ± 2.82. Compared to a free drug, TGS exhibited more prolonged drug release of 71.28 ± 0.46% after 8 h, higher ex vivo permeation of 66.82 ± 1.11% after 8 h and a significant lowering of intraocular pressure (IOP) for 24 h. Therefore, TGS provided a promising technique for improving the corneal delivery of ACZ.

scholarly journals Chitosan Nanoparticles of 5-Fluorouracil for Ophthalmic Delivery: Characterization, in-Vitro and in-Vivo Study

2011 ◽  
Vol 59 (2) ◽  
pp. 272-278 ◽  
Author(s):  
Ramesh Chand Nagarwal ◽  
Paras Nath Singh ◽  
Shri Kant ◽  
Pralay Maiti ◽  
Jayanta Kumar Pandit
Keyword(s):  
Chitosan Nanoparticles ◽  
In Vivo Study ◽  
Ophthalmic Delivery

In-vitro Characterization of Chitosan Nanoparticles of Fluconazole as a Carrier for Sustained Ocular Delivery

2017 ◽  
Vol 7 (1) ◽  
pp. 41-50 ◽  
Author(s):  
Kumaraswamy Santhi ◽  
Selvadurai Muralidharan ◽  
Young H. Yee ◽  
Fong M. Min ◽  
Chong Z. Ting ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Ocular Delivery ◽  
In Vitro Characterization
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