Correlations between acetylcholinesterase inhibition, acetylcholine levels and EEG changes during perfusion with neostigmine and N6-cyclopentyladenosine in rat brain

2007 ◽  
Vol 555 (2-3) ◽  
pp. 122-128 ◽  
Author(s):  
Marloes J.A. Joosen ◽  
Herman P.M. van Helden
Keyword(s):  
Rat Brain ◽  
Acetylcholinesterase Inhibition ◽  
Eeg Changes

Finasteride improves motor, EEG, and cellular changes in rat brain in thioacetamide-induced hepatic encephalopathy

2014 ◽  
Vol 307 (9) ◽  
pp. G931-G940 ◽  
Author(s):  
Dušan Mladenović ◽  
Dragan Hrnčić ◽  
Nataša Petronijević ◽  
Gordana Jevtić ◽  
Tatjana Radosavljević ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Rat Brain ◽  
Hepatic Coma ◽  
Treated Group ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Placement Test ◽  
Cellular Changes ◽  
Corneal Reflex ◽  
Male Wistar Rats ◽  
Eeg Changes

Neurosteroids are involved in the pathogenesis of hepatic encephalopathy (HE). This study evaluated the effects of finasteride, inhibitor of neurosteroid synthesis, on motor, EEG, and cellular changes in rat brain in thioacetamide-induced HE. Male Wistar rats were divided into the following groups: 1) control; 2) thioacetamide-treated group, TAA (300 mg·kg−1·day−1); 3) finasteride-treated group, FIN (50 mg·kg−1·day−1); and 4) group treated with FIN and TAA (FIN + TAA). Daily doses of TAA and FIN were administered in three subsequent days intraperitoneally, and in the FIN + TAA group FIN was administered 2 h before every dose of TAA. Motor and reflex activity was determined at 0, 2, 4, 6, and 24 h, whereas EEG activity was registered about 24 h after treatment. The expressions of neuronal (NeuN), astrocytic [glial fibrilary acidic protein (GFAP)], microglial (Iba1), and oligodendrocyte (myelin oligodendrocyte glycoprotein) marker were determined 24 h after treatment. While TAA decreased all tests, FIN pretreatment (FIN + TAA) significantly improved equilibrium, placement test, auditory startle, head shake reflex, motor activity, and exploratory behavior vs. the TAA group. Vital reflexes (withdrawal, grasping, righting and corneal reflex) together with mean EEG voltage were significantly higher ( P < 0.01) in the FIN + TAA vs. the TAA group. Hippocampal NeuN expression was significantly lower in TAA vs. control ( P < 0.05). Cortical Iba1 expression was significantly higher in experimental groups vs. control ( P < 0.05), whereas hippocampal GFAP expression was increased in TAA and decreased in the FIN + TAA group vs. control ( P < 0.05). Finasteride improves motor and EEG changes in TAA-induced HE and completely prevents the development of hepatic coma.

Oxygen Toxicity Is Reduced by Acetylcholinesterase Inhibition in the Developing Rat Brain

2013 ◽  
Vol 35 (2-3) ◽  
pp. 255-264 ◽  
Author(s):  
Marco Sifringer ◽  
Ivo Bendix ◽  
Clarissa von Haefen ◽  
Stefanie Endesfelder ◽  
Alexander Kalb ◽  
...  
Keyword(s):  
Rat Brain ◽  
Oxygen Toxicity ◽  
Acetylcholinesterase Inhibition ◽  
Developing Rat

Protective effect of l-phenylalanine on rat brain acetylcholinesterase inhibition induced by free radicals

2000 ◽  
Vol 33 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Stylianos Tsakiris ◽  
Panagoula Angelogianni ◽  
Kleopatra H. Schulpis ◽  
John C. Stavridis
Keyword(s):  
Free Radicals ◽  
Protective Effect ◽  
Rat Brain ◽  
Acetylcholinesterase Inhibition ◽  
Brain Acetylcholinesterase

cDNA cloning and expression of a gamma-aminobutyric acidA receptor epsilon-subunit in rat brain

2000 ◽  
Vol 12 (12) ◽  
pp. 4318-4330 ◽  
Author(s):  
Nathalie Moragues ◽  
Philippe Ciofi ◽  
Pierrette Lafon ◽  
Marie-Francoise Odessa ◽  
Gerard Tramu ◽  
...  
Keyword(s):  
Rat Brain ◽  
Cdna Cloning ◽  
Cloning And Expression ◽  
Epsilon Subunit
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