Electrochemical study of rat brain acetylcholinesterase inhibition by chlorofos: Kinetic aspects and analytical applications

2009 ◽  
Vol 55 (2) ◽  
pp. 516-520 ◽  
Author(s):  
Marcela Ovalle ◽  
Margarita Stoytcheva ◽  
Roumen Zlatev ◽  
Benjamin Valdez
Keyword(s):  
Rat Brain ◽  
Electrochemical Study ◽  
Acetylcholinesterase Inhibition ◽  
Analytical Applications ◽  
Brain Acetylcholinesterase

Protective effect of l-phenylalanine on rat brain acetylcholinesterase inhibition induced by free radicals

2000 ◽  
Vol 33 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Stylianos Tsakiris ◽  
Panagoula Angelogianni ◽  
Kleopatra H. Schulpis ◽  
John C. Stavridis
Keyword(s):  
Free Radicals ◽  
Protective Effect ◽  
Rat Brain ◽  
Acetylcholinesterase Inhibition ◽  
Brain Acetylcholinesterase

scholarly journals Binding of 125I-fasciculin to rat brain acetylcholinesterase. The complex still binds diisopropyl fluorophosphate

1993 ◽  
Vol 268 (17) ◽  
pp. 12458-12467
Author(s):  
P. Marchot ◽  
A. Khélif ◽  
Y.H. Ji ◽  
P. Mansuelle ◽  
P.E. Bougis
Keyword(s):  
Rat Brain ◽  
Diisopropyl Fluorophosphate ◽  
Brain Acetylcholinesterase

Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent

2004 ◽  
Vol 23 (4) ◽  
pp. 167-171 ◽  
Author(s):  
Kamil Kuča ◽  
Jiří Kassa
Keyword(s):  
Rat Brain ◽  
Brain Homogenate ◽  
Hi 6 ◽  
Brain Acetylcholinesterase

A comparison of one mono- and seven bisquaternary acetylcholinesterase (AChE) reactivators of acetylcholinesterase inhibited by VX agent was performed. As a source of the acetylcholinesterase, a rat brain homogenate was taken. There were significant differences in reactivation potency of all tested oximes. The oxime TO205 seems to be the most efficacious followed by TO046, HI-6, HS-6, K027, obidoxime, MMC and 2-PAM. In addition, the results of this study showed that the reactivation potency of the tested reactivators depends on many factors-such as the number of pyridinium rings, the number of oxime groups and their position, as well as the length and the shape of linkage bridge between two pyridinium rings.

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