Influence of polymer molecular weight on in vitro dissolution behavior and in vivo performance of celecoxib:PVP amorphous solid dispersions

2016 ◽  
Vol 101 ◽  
pp. 145-151 ◽  
Author(s):  
Matthias Manne Knopp ◽  
Julia Hoang Nguyen ◽  
Christian Becker ◽  
Nadine Monika Francke ◽  
Erling B. Jørgensen ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
In Vitro Dissolution ◽  
Dissolution Behavior ◽  
Polymer Molecular Weight ◽  
Amorphous Solid Dispersions

scholarly journals In Vitro and In Vivo Evaluation of Amorphous Solid Dispersions Generated by Different Bench-Scale Processes, Using Griseofulvin as a Model Compound

2013 ◽  
Vol 15 (2) ◽  
pp. 608-617 ◽  
Author(s):  
Po-Chang Chiang ◽  
Yong Cui ◽  
Yingqing Ran ◽  
Joe Lubach ◽  
Kang-Jye Chou ◽  
...  
Keyword(s):  
Model Compound ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
In Vivo Evaluation ◽  
Bench Scale

In Vitro and In Vivo Behaviors of KinetiSol and Spray-Dried Amorphous Solid Dispersions of a Weakly Basic Drug and Ionic Polymer

2020 ◽  
Vol 17 (8) ◽  
pp. 2789-2808 ◽  
Author(s):  
Scott V. Jermain ◽  
Michael B. Lowinger ◽  
Daniel J. Ellenberger ◽  
Dave A. Miller ◽  
Yongchao Su ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
Basic Drug ◽  
Ionic Polymer ◽  
Spray Dried

scholarly journals Effect of Polymer Molecular Weight on the Crystallization Behavior of Indomethacin Amorphous Solid Dispersions

2017 ◽  
Vol 17 (6) ◽  
pp. 3142-3150 ◽  
Author(s):  
Sarat Mohapatra ◽  
Subarna Samanta ◽  
Khushboo Kothari ◽  
Pinal Mistry ◽  
Raj Suryanarayanan
Keyword(s):  
Molecular Weight ◽  
Crystallization Behavior ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Polymer Molecular Weight ◽  
Amorphous Solid Dispersions

Solvent-Casted Films to Assist Polymer Selection for Amorphous Solid Dispersions During Preclinical Studies: In-vitro and In-vivo Exploration

2021 ◽  
Author(s):  
Laura I. Mosquera-Giraldo ◽  
Maria Donoso ◽  
Kevin Stefanski ◽  
Kimberly Foster ◽  
Christoph Gesenberg ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Amorphous Solid ◽  
Preclinical Studies ◽  
Amorphous Solid Dispersions ◽  
Selection For

scholarly journals Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation Challenges in Paediatric Populations

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1114
Author(s):  
Janine Boniatti ◽  
Patricija Januskaite ◽  
Laís B. da Fonseca ◽  
Alessandra L. Viçosa ◽  
Fábio C. Amendoeira ◽  
...  
Keyword(s):  
3D Printing ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Fold Increase ◽  
In Vitro Dissolution ◽  
Taste Masking ◽  
Fused Deposition Modelling ◽  
Amorphous Solid Dispersions ◽  
Fused Deposition

For the last 40 years, praziquantel has been the standard treatment for schistosomiasis, a neglected parasitic disease affecting more than 250 million people worldwide. However, there is no suitable paediatric formulation on the market, leading to off-label use and the splitting of commercial tablets for adults. In this study, we use a recently available technology, direct powder extrusion (DPE) three-dimensional printing (3DP), to prepare paediatric Printlets™ (3D printed tablets) of amorphous solid dispersions of praziquantel with Kollidon® VA 64 and surfactants (Span™ 20 or Kolliphor® SLS). Printlets were successfully printed from both pellets and powders obtained from extrudates by hot melt extrusion (HME). In vitro dissolution studies showed a greater than four-fold increase in praziquantel release, due to the formation of amorphous solid dispersions. In vitro palatability data indicated that the printlets were in the range of praziquantel tolerability, highlighting the taste masking capabilities of this technology without the need for additional taste masking excipients. This work has demonstrated the possibility of 3D printing tablets using pellets or powder forms obtained by HME, avoiding the use of filaments in fused deposition modelling 3DP. Moreover, the main formulation hurdles of praziquantel, such as low drug solubility, inadequate taste, and high and variable dose requirements, can be overcome using this technology.

scholarly journals Influence of Copolymer Composition on In Vitro and In Vivo Performance of Celecoxib-PVP/VA Amorphous Solid Dispersions

2016 ◽  
Vol 18 (2) ◽  
pp. 416-423 ◽  
Author(s):  
Matthias Manne Knopp ◽  
Julia Hoang Nguyen ◽  
Huiling Mu ◽  
Peter Langguth ◽  
Thomas Rades ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Amorphous Solid ◽  
Copolymer Composition ◽  
Amorphous Solid Dispersions

Predicting in vivo performance of fenofibrate amorphous solid dispersions using in vitro non-sink dissolution and dissolution permeation setup

2021 ◽  
pp. 121174
Author(s):  
Karoline Aagaard Lentz ◽  
Jakob Plum ◽  
Bente Steffansen ◽  
Per-Ola Arvidsson ◽  
Diana Højmark Omkvist ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions
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