Oxidative stress-mediated cytotoxicity and apoptosis induction by TiO2 nanofibers in HeLa cells

2012 ◽  
Vol 81 (2) ◽  
pp. 324-333 ◽  
Author(s):  
Kunga Mohan Ramkumar ◽  
Chinnasamy Manjula ◽  
Georgepeter GnanaKumar ◽  
Muzafar A. Kanjwal ◽  
Thillai V. Sekar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hela Cells ◽  
Apoptosis Induction ◽  
Tio2 Nanofibers

scholarly journals Cytotoxicity induced by new spiral mesoporous silica nanorods via specific surface area and ROS accumulation in HeLa cells

2020 ◽  
Vol 1 (9) ◽  
pp. 3556-3564
Author(s):  
Lan She ◽  
Miao Sun ◽  
Xinfang Li ◽  
Anfeng Kang ◽  
Feng Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mesoporous Silica ◽  
Cell Viability ◽  
Specific Surface ◽  
Surface Area ◽  
Specific Surface Area ◽  
Hela Cells ◽  
Ros Accumulation ◽  
Silica Nanorods

Results indicated that the effect of MSNRs on cell viability and cellular oxidative stress was related to specific surface area.

Promotion of HeLa cells apoptosis by cynaropicrin involving inhibition of thioredoxin reductase and induction of oxidative stress

2019 ◽  
Vol 135 ◽  
pp. 216-226 ◽  
Author(s):  
Tianyu Liu ◽  
Junmin Zhang ◽  
Xiao Han ◽  
Jianqiang Xu ◽  
Yueting Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hela Cells ◽  
Thioredoxin Reductase

scholarly journals Lysosome Dysfunction Enhances Oxidative Stress-Induced Apoptosis through Ubiquitinated Protein Accumulation in Hela Cells

2012 ◽  
Vol 296 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Chunyan Yu ◽  
Xiaowei Huang ◽  
Ye Xu ◽  
Hongyan LI ◽  
Jing Su ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hela Cells ◽  
Protein Accumulation ◽  
Ubiquitinated Protein ◽  
Induced Apoptosis

Apoptosis Induction by Pseudorabies Virus via Oxidative Stress and Subsequent DNA Damage Signaling

Intervirology ◽  
2019 ◽  
Vol 62 (3-4) ◽  
pp. 116-123 ◽  
Author(s):  
I-Hsiang Lai ◽  
Ching-Dong Chang ◽  
Wen-Ling Shih
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Pseudorabies Virus ◽  
Apoptosis Induction ◽  
Dna Damage Signaling

Zinc resistance impairs sensitivity to oxidative stress in hela cells: protection through metallothioneins expression

2001 ◽  
Vol 31 (10) ◽  
pp. 1179-1190 ◽  
Author(s):  
Fabrice Chimienti ◽  
Eric Jourdan ◽  
Alain Favier ◽  
Michel Seve
Keyword(s):  
Oxidative Stress ◽  
Hela Cells ◽  
Zinc Resistance

The involvement of oxidative stress in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in HeLa cells

2002 ◽  
Vol 182 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Myoung Woo Lee ◽  
Soon Cheol Park ◽  
Joung-Hun Kim ◽  
In-Ki Kim ◽  
Kun Soo Han ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Tumor Necrosis Factor ◽  
Hela Cells ◽  
Tumor Necrosis ◽  
Induced Apoptosis ◽  
Necrosis Factor

scholarly journals BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma

2010 ◽  
Vol 103 (12) ◽  
pp. 1808-1814 ◽  
Author(s):  
L Bodet ◽  
E Ménoret ◽  
G Descamps ◽  
C Pellat-Deceunynck ◽  
R Bataille ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Myeloma ◽  
Apoptosis Induction

scholarly journals Loss of Bif-1 Suppresses Bax/Bak Conformational Change and Mitochondrial Apoptosis

2005 ◽  
Vol 25 (21) ◽  
pp. 9369-9382 ◽  
Author(s):  
Yoshinori Takahashi ◽  
Mariusz Karbowski ◽  
Hirohito Yamaguchi ◽  
Aslamuzzaman Kazi ◽  
Jie Wu ◽  
...  
Keyword(s):  
Conformational Change ◽  
Hela Cells ◽  
Caspase 3 ◽  
Soft Agar ◽  
Mitochondrial Pathway ◽  
Apoptosis Induction ◽  
Mouse Embryonic Fibroblasts ◽  
Embryonic Fibroblasts ◽  
Intact Cells ◽  
Death Signals

ABSTRACT Bif-1, a member of the endophilin B protein family, interacts with Bax and promotes interleukin-3 withdrawal-induced Bax conformational change and apoptosis when overexpressed in FL5.12 cells. Here, we provide evidence that Bif-1 plays a regulatory role in apoptotic activation of not only Bax but also Bak and appears to be involved in suppression of tumorigenesis. Inhibition of endogenous Bif-1 expression in HeLa cells by RNA interference abrogated the conformational change of Bax and Bak, cytochrome c release, and caspase 3 activation induced by various intrinsic death signals. Similar results were obtained in Bif-1 knockout mouse embryonic fibroblasts. While Bif-1 did not directly interact with Bak, it heterodimerized with Bax on mitochondria in intact cells, and this interaction was enhanced by apoptosis induction and preceded the Bax conformational change. Moreover, suppression of Bif-1 expression was associated with an enhanced ability of HeLa cells to form colonies in soft agar and tumors in nude mice. Taken together, these findings support the notion that Bif-1 is an important component of the mitochondrial pathway for apoptosis as a novel Bax/Bak activator, and loss of this proapoptotic molecule may contribute to tumorigenesis.

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