Gellan gum blended PEI nanocomposites as gene delivery agents: Evidences from in vitro and in vivo studies

2011 ◽  
Vol 79 (1) ◽  
pp. 3-14 ◽  
Author(s):  
Ritu Goyal ◽  
S.K. Tripathi ◽  
Shilpa Tyagi ◽  
K. Ravi Ram ◽  
K.M. Ansari ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Gellan Gum ◽  
In Vivo Studies

Engineered PEI-piperazinyl nanoparticles as efficient gene delivery vectors: evidence from both in vitro and in vivo studies

RSC Advances ◽  
2012 ◽  
Vol 2 (10) ◽  
pp. 4335 ◽  
Author(s):  
Soma Patnaik ◽  
Ritu Goyal ◽  
Sushil K. Tripathi ◽  
Mohammed Arif ◽  
Kailash C. Gupta
Keyword(s):  
Gene Delivery ◽  
In Vivo Studies ◽  
Gene Delivery Vectors ◽  
Efficient Gene

Gellan gum and its methacrylated derivatives as in situ gelling mucoadhesive formulations of pilocarpine: In vitro and in vivo studies

2020 ◽  
Vol 577 ◽  
pp. 119093 ◽  
Author(s):  
Laura E. Agibayeva ◽  
Daulet B. Kaldybekov ◽  
Natalia N. Porfiryeva ◽  
Venera R. Garipova ◽  
Rauash A. Mangazbayeva ◽  
...  
Keyword(s):  
Gellan Gum ◽  
In Vivo Studies ◽  
In Situ Gelling

Development of floating in situ gelling system as an efficient anti-ulcer formulation: in vitro and in vivo studies

RSC Advances ◽  
2015 ◽  
Vol 5 (37) ◽  
pp. 28848-28856 ◽  
Author(s):  
C. Bothiraja ◽  
Vijay Kumbhar ◽  
Atmaram Pawar ◽  
Karimunnisa Shaikh ◽  
Ravindra Kamble
Keyword(s):  
Calcium Carbonate ◽  
Gellan Gum ◽  
In Vivo Studies ◽  
Model Drug ◽  
In Situ Gelling

The aim of the present work was to design gellan gum and calcium carbonate based floating in situ gel as an efficient anti-ulcer formulation using andrographolide (AG) as a model drug.

scholarly journals A Valid Bisphosphonate Modified Calcium Phosphate-Based Gene Delivery System: Increased Stability and Enhanced Transfection Efficiency In Vitro and In Vivo

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 468 ◽  
Author(s):  
Zhao ◽  
Li ◽  
Chen ◽  
Hu
Keyword(s):  
Calcium Phosphate ◽  
Gene Delivery ◽  
Tissue Specificity ◽  
Transfection Efficiency ◽  
Hybrid Nanoparticles ◽  
In Vivo Studies ◽  
Adsorptive Capacity ◽  
Low Cytotoxicity

Calcium phosphate (CaP) nanoparticles, as a promising vehicle for gene delivery, have been widely used owing to their biocompatibility, biodegradability and adsorptive capacity for nucleic acids. Unfortunately, their utility in vivo has been profoundly restricted due to numerous technical barriers such as the lack of tissue specificity and limited transfection efficiency, as well as uncontrollable aggregation over time. To address these issues, an effective conjugate folate-polyethylene glycol-pamidronate (shortened as FA-PEG-Pam) was designed and coated on the surface of CaP/NLS/pDNA (CaP/NDs), forming a versatile gene carrier FA-PEG-Pam/CaP/NDs. Inclusion of FA-PEG-Pam significantly reduced the size of CaP nanoparticles, thus inhibiting the aggregation of CaP nanoparticles. FA-PEG-Pam/CaP/NDs showed better cellular uptake than mPEG-Pam/CaP/NDs, which could be attributed to the high-affinity interactions between FA and highly expressed FR. Meanwhile, FA-PEG-Pam/CaP/NDs had low cytotoxicity and desired effect on inducing apoptosis (71.1%). Furthermore, FA-PEG-Pam/CaP/NDs showed admirable transfection efficiency (63.5%) due to the presence of NLS peptides. What’s more, in vivo studies revealed that the hybrid nanoparticles had supreme antitumor activity (IR% = 58.7%) among the whole preparations. Altogether, FA-PEG-Pam/CaP/NDs was expected to be a hopeful strategy for gene delivery.

In vitro and in vivo studies of new cationic Zn(II)‐benzonaphthoporphyrazines as photosensitizers for PDT

2001 ◽  
Vol 5 (8) ◽  
pp. 645-651
Author(s):  
M. Peeva ◽  
M. Shopova ◽  
U. Michelsen ◽  
D. Wöhrle ◽  
G. Petrov ◽  
...  
Keyword(s):  
In Vivo Studies

Effect of caffeine on theophyliine on cerebral blood flow response to brain activation: In vitro and in vivo studies

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S198-S198
Author(s):  
Joseph R Meno ◽  
Thien-son K Nguyen ◽  
Elise M Jensen ◽  
G Alexander West ◽  
Leonid Groysman ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Activation ◽  
In Vivo Studies ◽  
Blood Flow Response ◽  
Flow Response
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