scholarly journals Aggregated Nanotransfersomal Dry Powder Inhalation of Itraconazole for Pulmonary Drug Delivery

2016 ◽  
Vol 6 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Mehdi Hassanpour Aghdam ◽  
Saeed Ghanbarzadeh ◽  
Yousef Javadzadeh ◽  
Hamed Hamishehkar
Keyword(s):  
Drug Delivery ◽  
Pulmonary Drug Delivery ◽  
Dry Powder Inhalation ◽  
Dry Powder

scholarly journals Dry powder aerosol containing muco-inert particles for excipient enhanced growth pulmonary drug delivery

2020 ◽  
Vol 29 ◽  
pp. 102262
Author(s):  
Guihong Chai ◽  
Amr Hassan ◽  
Tuo Meng ◽  
Lihua Lou ◽  
Jonathan Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pulmonary Drug Delivery ◽  
Dry Powder ◽  
Inert Particles ◽  
Dry Powder Aerosol ◽  
Powder Aerosol

scholarly journals Development of a Carrier Free Dry Powder Inhalation Formulation of Ketotifen for Pulmonary Drug Delivery

Drug Research ◽  
2019 ◽  
Vol 70 (01) ◽  
pp. 26-32
Author(s):  
Fariba Azari ◽  
Saeed Ghanbarzadeh ◽  
Rezvan Safdari ◽  
Shadi Yaqoubi ◽  
Khosro Adibkia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Spray Drying ◽  
Dry Powder Inhaler ◽  
Ammonium Bicarbonate ◽  
Pulmonary Drug Delivery ◽  
Water Mixture ◽  
Dry Powder ◽  
Scanning Calorimetry ◽  
Aerodynamic Properties ◽  
Systemic Treatments

Abstract Background Pulmonary drug delivery route is gaining much attention because it enables to target the active ingredients directly to lung both for local and systemic treatments, which maximize the therapeutic effect and minimize unwanted systemic toxicity. Dry powder inhaler (DPI) systems for asthma therapy have shown several merits to the other pulmonary delivery systems such as nebulizers and metered dose inhalers. Purpose The present study aims to develop and optimize a DPI formulation for Ketotifen fumarate through spray drying technique. Methods Particles size and morphology, crystallinity, and drug-excipient interaction of fabricated DPI formulations were evaluated by scanning electron microscopy, X-ray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier Transform Infrared Spectroscopy methods, respectively. The aerosolization indexes and aerodynamic properties of dry powders were determined by next generation impactor. The powder flowability was assessed by measuring the Hausner ratio and compressibility index. Results Among solvent systems, ethanol-water mixture produced the most desirable powder property for inhalation after spray drying. Although co-spray dried formulations with ammonium bicarbonate resulted in the porous structure, it was not beneficial for DPI formulations due to the interaction with Ketotifen. DSC and XRD experiments proved the amorphous structure of prepared powders, which were stable for 12 months. Conclusion The results of this study demonstrate the potential of Ketotifen DPI formulation and pave a way to use it easily in an industrial scale.

A multilayer hollow nanocarrier for pulmonary co-drug delivery of methotrexate and doxorubicin in the form of dry powder inhalation formulation

2019 ◽  
Vol 99 ◽  
pp. 752-761 ◽  
Author(s):  
Saeideh Nozohouri ◽  
Roya Salehi ◽  
Saeed Ghanbarzadeh ◽  
Khosro Adibkia ◽  
Hamed Hamishehkar
Keyword(s):  
Drug Delivery ◽  
Dry Powder Inhalation ◽  
Dry Powder

Amorphous solid dispersion dry powder for pulmonary drug delivery: Advantages and challenges

2020 ◽  
Vol 587 ◽  
pp. 119711
Author(s):  
Khaled AboulFotouh ◽  
Yi Zhang ◽  
Mohammed Maniruzzaman ◽  
Robert O. Williams ◽  
Zhengrong Cui
Keyword(s):  
Drug Delivery ◽  
Solid Dispersion ◽  
Amorphous Solid ◽  
Pulmonary Drug Delivery ◽  
Amorphous Solid Dispersion ◽  
Dry Powder
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