Prognostic significance of DNMT3A alterations in Middle Eastern papillary thyroid carcinoma

2019 ◽  
Vol 117 ◽  
pp. 133-144 ◽  
Author(s):  
Abdul K. Siraj ◽  
Poyil Pratheeshkumar ◽  
Sandeep Kumar Parvathareddy ◽  
Rong Bu ◽  
Tariq Masoodi ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Middle Eastern ◽  
Prognostic Significance ◽  
Papillary Thyroid

scholarly journals Prognostic Significance of COX-2 Overexpression in BRAF-Mutated Middle Eastern Papillary Thyroid Carcinoma

2020 ◽  
Vol 21 (24) ◽  
pp. 9498
Author(s):  
Sandeep Kumar Parvathareddy ◽  
Abdul K. Siraj ◽  
Padmanaban Annaiyappanaidu ◽  
Saif S. Al-Sobhi ◽  
Fouad Al-Dayel ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Braf Mutation ◽  
Middle Eastern ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Papillary Thyroid ◽  
Mutation Status ◽  
Cox 2 ◽  
Braf Mutant

The cyclooxygenase-2 (COX-2)–prostaglandin E2 (PGE2) pathway has been implicated in carcinogenesis, with BRAF mutation shown to promote PGE2 synthesis. This study was conducted to evaluate COX-2 expression in a large cohort of Middle Eastern papillary thyroid carcinoma (PTC), and further evaluate the prognostic significance of COX-2 expression in strata of BRAF mutation status. BRAF mutation analysis was performed using Sanger sequencing, and COX-2 expression was evaluated immunohistochemically using tissue microarray (TMA). COX-2 overexpression, noted in 43.2% (567/1314) of cases, was significantly associated with poor prognostic markers such as extra-thyroidal extension, lymph-node metastasis, and higher tumor stage. COX-2 was also an independent predictor of poor disease-free survival (DFS). Most notably, the association of COX-2 expression with DFS differed by BRAF mutation status. COX-2 overexpression was associated with poor DFS in BRAF-mutant but not BRAF wild-type PTCs, with a multivariate-adjusted hazard ratio of 2.10 (95% CI = 1.52–2.92; p < 0.0001) for COX-2 overexpressed tumors in BRAF-mutant PTC. In conclusion, the current study shows that COX-2 plays a key role in prognosis of PTC patients, especially in BRAF-mutated tumors. Our data suggest the potential therapeutic role of COX-2 inhibition in patients with BRAF-mutated PTC.

Papillary thyroid carcinoma in Kanazawa, Japan: prognostic significance of histological subtypes

1992 ◽  
Vol 20 (3) ◽  
pp. 243-250 ◽  
Author(s):  
Y. MIZUKAMI ◽  
M. NOGUCHI ◽  
T. MICHIGISHI ◽  
A. NONOMURA ◽  
T. HASHIMOTO ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Prognostic Significance ◽  
Papillary Thyroid ◽  
Histological Subtypes

Abstract 3117: Pleiotrophin is a marker of poor prognosis in Middle Eastern papillary thyroid carcinoma

2016 ◽  
Author(s):  
Shaham Beg ◽  
Maqbool Ahmed ◽  
Azhar Hussein ◽  
Rong Bu ◽  
Zeeshan Qadri ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Poor Prognosis ◽  
Middle Eastern ◽  
Papillary Thyroid
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