Clinicopathologic and prognostic significance of the expression of mucins, simple mucin antigens and histoblood group antigens in papillary thyroid carcinoma

1999 ◽  
Vol 10 (4) ◽  
pp. 305-313 ◽  
Author(s):  
Pedro Alves ◽  
Paula Soares ◽  
Simone Rossi ◽  
Elsa Fonseca ◽  
Manuel Sobrinho-Simões
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Prognostic Significance ◽  
Papillary Thyroid ◽  
Simple Mucin Antigens

Papillary thyroid carcinoma in Kanazawa, Japan: prognostic significance of histological subtypes

1992 ◽  
Vol 20 (3) ◽  
pp. 243-250 ◽  
Author(s):  
Y. MIZUKAMI ◽  
M. NOGUCHI ◽  
T. MICHIGISHI ◽  
A. NONOMURA ◽  
T. HASHIMOTO ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Prognostic Significance ◽  
Papillary Thyroid ◽  
Histological Subtypes

Prognostic significance of DNMT3A alterations in Middle Eastern papillary thyroid carcinoma

2019 ◽  
Vol 117 ◽  
pp. 133-144 ◽  
Author(s):  
Abdul K. Siraj ◽  
Poyil Pratheeshkumar ◽  
Sandeep Kumar Parvathareddy ◽  
Rong Bu ◽  
Tariq Masoodi ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Middle Eastern ◽  
Prognostic Significance ◽  
Papillary Thyroid

scholarly journals The prognostic significance of tall cells in papillary thyroid carcinoma: A case-control study

Tumor Biology ◽  
2018 ◽  
Vol 40 (7) ◽  
pp. 101042831878772 ◽  
Author(s):  
Sebastian Stenman ◽  
Päivi Siironen ◽  
Harri Mustonen ◽  
Johan Lundin ◽  
Caj Haglund ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Adverse Outcome ◽  
Prognostic Significance ◽  
World Health ◽  
Papillary Thyroid ◽  
Cell Composition ◽  
Tall Cell Variant ◽  
Tall Cell ◽  
Cell Variant

The subtype of the papillary thyroid carcinoma tall-cell variant has a worse prognosis than does the conventional papillary type (papillary thyroid carcinoma). The new World Health Organization 2017 classification defines a tall-cell variant as a tumour consisting of over 30% of cells that are two or three times as tall as they are wide. However, thresholds have differed. Our aim was to study how tall cells affect the prognosis of papillary thyroid carcinoma patients and to determine, for such cells, a cut-off percentage. Our cohort included 65 papillary thyroid carcinoma patients who underwent surgery at Helsinki University Hospital between 1973 and 1996: originally, 36 otherwise-matched patient pairs, eventually comprising 34 patients with an adverse outcome plus 31 who had recovered. All samples were digitally scanned and scored by two investigators based on tall cell composition. The cohort was analysed with four tall cell thresholds: 10%, 30%, 50% and 70% with a median follow-up of 22 years. In survival analysis, only the 70% threshold showed a correlation with reduced overall survival, disease-specific survival and relapse-free survival. A correlation also emerged with death from papillary thyroid carcinoma. In multivariate analysis, a 70% cut-off and age at diagnosis significantly affected DSS. Increasing tall cell score correlated with increasing age and extrathyroidal extensions. A tall cell composition of 10%, 30% or 50% showed no correlation with adverse outcome and suggests that the choice of pathologists reporting tall-cell variant should be a 70% threshold.

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