OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis

Lucile Astorgues-Xerri; Maria E. Riveiro; Annemilaï Tijeras-Raballand; Maria Serova; Gabriel A. Rabinovich; Ivan Bieche; Michel Vidaud; Armand de Gramont; Mathieu Martinet; Esteban Cvitkovic; Sandrine Faivre; Eric Raymond

doi:10.1016/j.ejca.2014.06.015

OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis

European Journal of Cancer ◽

10.1016/j.ejca.2014.06.015 ◽

2014 ◽

Vol 50 (14) ◽

pp. 2463-2477 ◽

Cited By ~ 47

Author(s):

Lucile Astorgues-Xerri ◽

Maria E. Riveiro ◽

Annemilaï Tijeras-Raballand ◽

Maria Serova ◽

Gabriel A. Rabinovich ◽

...

Keyword(s):

Cell Proliferation ◽

Cancer Cell ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Cancer Cell Proliferation ◽

Tumour Angiogenesis ◽

Molecule Inhibitor

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Abstract 1640: A novel small molecule inhibitor of lysophosphatidic acid acyltransferase-beta inhibits pancreatic cancer cell proliferation and mTOR signaling

10.1158/1538-7445.am2014-1640 ◽

2014 ◽

Author(s):

Michelle A. Blaskovich ◽

Yunting Luo ◽

Yiyu Ge ◽

Saïd M. Sebti ◽

Harshani R. Lawrence ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cell Proliferation ◽

Cancer Cell ◽

Small Molecule ◽

Lysophosphatidic Acid ◽

Pancreatic Cancer Cell ◽

Small Molecule Inhibitor ◽

Mtor Signaling ◽

Cancer Cell Proliferation ◽

Molecule Inhibitor

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Novel Stat3 Small Molecule Inhibitor Selectively Inhibits Mesothelin-Overexpressing Pancreatic Cancer Cell Proliferation

Journal of Surgical Research ◽

10.1016/j.jss.2010.11.353 ◽

2011 ◽

Vol 165 (2) ◽

pp. 303

Author(s):

U. Bharadwaj ◽

D.J. Tweardy ◽

C. Chen ◽

Q. Yao

Keyword(s):

Pancreatic Cancer ◽

Cell Proliferation ◽

Cancer Cell ◽

Small Molecule ◽

Pancreatic Cancer Cell ◽

Small Molecule Inhibitor ◽

Cancer Cell Proliferation ◽

Molecule Inhibitor

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Small molecule inhibitor of TLR4 inhibits ovarian cancer cell proliferation: new insight into the anticancer effect of TAK-242 (Resatorvid)

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-019-03988-y ◽

2019 ◽

Vol 85 (1) ◽

pp. 47-59 ◽

Cited By ~ 6

Author(s):

Bahareh Kashani ◽

Zahra Zandi ◽

Davood Bashash ◽

Azam Zaghal ◽

Majid Momeny ◽

...

Keyword(s):

Ovarian Cancer ◽

Cell Proliferation ◽

Cancer Cell ◽

Small Molecule ◽

Ovarian Cancer Cell ◽

Small Molecule Inhibitor ◽

Cancer Cell Proliferation ◽

Anticancer Effect ◽

Molecule Inhibitor ◽

Insight Into

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Small Molecule Targeting of Oxysterol-Binding Protein (OSBP)-Related Protein 4 and OSBP Inhibits Ovarian Cancer Cell Proliferation in Monolayer and Spheroid Cell Models

ACS Pharmacology & Translational Science ◽

10.1021/acsptsci.0c00207 ◽

2021 ◽

Vol 4 (2) ◽

pp. 744-756

Author(s):

Ryan C. Bensen ◽

Gokhan Gunay ◽

Matthew C. Finneran ◽

Isha Jhingan ◽

Handan Acar ◽

...

Keyword(s):

Ovarian Cancer ◽

Cell Proliferation ◽

Cancer Cell ◽

Small Molecule ◽

Ovarian Cancer Cell ◽

Binding Protein ◽

Cancer Cell Proliferation ◽

Related Protein ◽

Cell Models ◽

Oxysterol Binding Protein

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Inhibition of Tumor Growth, Angiogenesis, and Tumor Cell Proliferation by a Small Molecule Inhibitor of c-Jun N-terminal Kinase

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.104.078873 ◽

2004 ◽

Vol 313 (1) ◽

pp. 325-332 ◽

Cited By ~ 46

Author(s):

Bruce W. Ennis ◽

Kimberly E. Fultz ◽

Kent A. Smith ◽

John K. Westwick ◽

Dan Zhu ◽

...

Keyword(s):

Cell Proliferation ◽

Tumor Growth ◽

Tumor Cell ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Tumor Cell Proliferation ◽

Molecule Inhibitor ◽

Inhibition Of Tumor Growth

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70 A Selective Small Molecule Inhibitor of Mcl-1 Induces Bak Dependent Apoptosis in Cancer Cell Lines

European Journal of Cancer ◽

10.1016/s0959-8049(12)71868-3 ◽

2012 ◽

Vol 48 ◽

pp. 23

Author(s):

D.C. Phillips ◽

Y. Xiao ◽

M. Bruncko ◽

C. Park ◽

H. Zhang ◽

...

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Small Molecule ◽

Cancer Cell Lines ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor

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A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts

PLoS ONE ◽

10.1371/journal.pone.0100993 ◽

2014 ◽

Vol 9 (6) ◽

pp. e100993 ◽

Cited By ~ 56

Author(s):

Fei Huang ◽

Alexander V. Mazin

Keyword(s):

Breast Cancer ◽

Cancer Cell ◽

Breast Cancer Cell ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Therapeutic Agents ◽

Cell Killing ◽

Molecule Inhibitor ◽

Human Rad51

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INC280, an orally available small molecule inhibitor of c-MET, reduces migration and adhesion in ovarian cancer cell models

Scientific Reports ◽

10.1038/srep11749 ◽

2015 ◽

Vol 5 (1) ◽

Cited By ~ 16

Author(s):

Kim Moran-Jones ◽

Laura M. Brown ◽

Goli Samimi

Keyword(s):

Ovarian Cancer ◽

Cancer Cell ◽

Small Molecule ◽

Ovarian Cancer Cell ◽

Small Molecule Inhibitor ◽

Cell Models ◽

Molecule Inhibitor

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Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not β-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation

Chemical Communications ◽

10.1039/c3cc48391f ◽

2014 ◽

Vol 50 (40) ◽

pp. 5388-5390 ◽

Cited By ~ 17

Author(s):

Michael J. Waring ◽

David M. Andrews ◽

Paul F. Faulder ◽

Vikki Flemington ◽

Jennifer C. McKelvie ◽

...

Keyword(s):

Cell Proliferation ◽

Cancer Cell ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Signaling Cascade ◽

Cancer Cell Proliferation ◽

Type Iii ◽

Phosphatidylinositol 4

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Faculty Opinions recommendation of MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725518097.793525480 ◽

2016 ◽

Author(s):

Scott Kaufmann ◽

Wei Meng

Keyword(s):

Breast Cancer ◽

Cell Survival ◽

Cancer Cell ◽

Breast Cancer Cell ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Molecule Inhibitor ◽

Cancer Cell Survival

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