Non-linear dose–response relationship between cigarette smoking and pancreatic cancer risk: Evidence from a meta-analysis of 42 observational studies

2014 ◽  
Vol 50 (1) ◽  
pp. 193-203 ◽  
Author(s):  
Li Zou ◽  
Rong Zhong ◽  
Na Shen ◽  
Wei Chen ◽  
Beibei Zhu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Cigarette Smoking ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Pancreatic Cancer Risk ◽  
Linear Dose

scholarly journals Vitamin B6, vitamin B12 and methionine and risk of pancreatic cancer: a meta-analysis

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Dan-Hong Wei ◽  
Qi-Qi Mao
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Vitamin B12 ◽  
Dose Response ◽  
Vitamin B6 ◽  
Meta Analysis ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Pancreatic Cancer Risk ◽  
Linear Dose

Abstract Background Nutrients involved in one-carbon metabolism may play a key role in pancreatic carcinogenesis. The aim of this study was to examine the association between pancreatic cancer risk and intake or blood levels of vitamins B6, B12 and methionine via meta-analysis. Methods A systematic search was performed in PubMed, Web of Knowledge and Chinese National Knowledge Infrastructure (CNKI) up to April 2020 to identify relevant studies. Risk estimates and their 95% confidence intervals (CIs) were retrieved from the studies and combined by a random-effect model. Results A total of 18 studies were included in this meta-analysis on the association of vitamin B6, B12 and methionine with pancreatic cancer risk. The combined risk estimate (95% CI) of pancreatic cancer for the highest vs lowest category of vitamin B6 intake and blood pyridoxal 5′-phosphate (PLP, active form of vitamin B6) levels was 0.63 (0.48–0.79) and 0.65 (0.52–0.79), respectively. The results indicated a non-linear dose-response relationship between vitamin B6 intake and pancreatic risk. Linear dose–response relationship was found, and the risk of pancreatic cancer decreased by 9% for every 10 nmol/L increment in blood PLP levels. No significant association were found between pancreatic cancer risk and vitamin B12 intake, blood vitamin B12 levels, methionine intake and blood methionine levels. Conclusion Our study suggests that high intake of vitamin B6 and high concentration of blood PLP levels may be protective against the development of pancreatic cancer. Further research are warranted to confirm the results.

scholarly journals A dose–response meta-analysis reveals an association between vitamin B12 and colorectal cancer risk

2015 ◽  
Vol 19 (8) ◽  
pp. 1446-1456 ◽  
Author(s):  
Nai-Hui Sun ◽  
Xuan-Zhang Huang ◽  
Shuai-Bo Wang ◽  
Yuan Li ◽  
Long-Yi Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dose Response ◽  
Meta Analysis ◽  
Dietary Vitamin ◽  
Vitamin B ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Total Vitamin ◽  
Linear Dose ◽  
Non Linear

AbstractObjectiveThe current meta-analysis evaluated the association between vitamin B12 intake and blood vitamin B12 level and colorectal cancer (CRC) risk.DesignThe PubMed and EMBASE databases were searched. A dose–response analysis was performed with generalized least squares regression, with the relative risk (RR) and 95 % CI as effect values.SettingThe meta-analysis included seventeen studies.SubjectsA total of 10 601 patients.ResultsThe non-linear dose–response relationship between total vitamin B12 intake and CRC risk was insignificant (P=0·690), but the relationship between dietary vitamin B12 intake and CRC risk was significant (P<0·001). Every 4·5 μg/d increment in total and dietary vitamin B12 intake was inversely associated with CRC risk (total intake: RR=0·963; 95 % CI 0·928, 0·999; dietary intake: RR=0·914; 95 % CI 0·856, 0·977). The inverse association between vitamin B12 intake and CRC risk was also significant when vitamin B12 intake was over a dosage threshold, enhancing the non-linear relationship. The non-linear dose–response relationship between blood vitamin B12 level and CRC risk was insignificant (P=0·219). There was an insignificant association between every 150 pmol/l increment in blood vitamin B12 level and CRC risk (RR=1·023; 95 % CI 0·881, 1·187).ConclusionsOur meta-analysis indicates that evidence supports the use of vitamin B12 for cancer prevention, especially among populations with high-dose vitamin B12 intake, and that the association between CRC risk and total vitamin B12 intake is stronger than between CRC risk and dietary vitamin B12 intake only.

scholarly journals Association between Smoking and Noise-Induced Hearing Loss: A Meta-Analysis of Observational Studies

2020 ◽  
Vol 17 (4) ◽  
pp. 1201
Author(s):  
Xiaowen Li ◽  
Xing Rong ◽  
Zhi Wang ◽  
Aihua Lin
Keyword(s):  
Hearing Loss ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
Fixed Effect Model ◽  
Noise Induced Hearing Loss ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Slow Decline ◽  
Former Smokers

The purpose of this study was to synthesize the results of previously published observational studies through meta-analysis to clarify the association between smoking and noise-induced hearing loss (NIHL). We searched several databases as of October 2019. Based on the results of heterogeneity analysis (Q statistic and I2 statistic), a fixed effect model (for no heterogeneity; Q test P > 0.1 and I2 ≤ 50%) or a random effects model (for heterogeneity) was used to calculate the pooled odds ratios (ORs). We explored the potential dose-response relationship between smoking and NIHL as well. In total, 27 studies involving 30,465 participants were included. Compared with non-smokers, the pooled OR of current smokers was 2.05 (95% Confidence interval (CI): 1.71–2.46), and of former smokers was 1.11 (95% CI: 1.05–1.18). We found a curve linear association between an increasing number of pack-years (packages/day × smoking years) and risk of NIHL. The dose-response meta-analysis suggested that when the number of pack-years was less than fifteen, the risk of NIHL was increasing, and the highest combined OR was 5.25 (95% CI: 2.30–11.96) for pack-years of fifteen. After fifteen pack-years, the pooled OR had a slow decline. Our study indicated that smoking is a risk factor for NIHL. Current smokers have a higher risk than former smokers, and there is a positive dose-response relationship between smoking and NIHL.

Folate intake and pancreatic cancer risk: an overall and dose–response meta-analysis

Public Health ◽  
2013 ◽  
Vol 127 (7) ◽  
pp. 607-613 ◽  
Author(s):  
H.L. Lin ◽  
Q.Z. An ◽  
Q.Z. Wang ◽  
C.X. Liu
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Folate Intake ◽  
Pancreatic Cancer Risk

scholarly journals Breastfeeding and the risk of childhood cancer: a systematic review and dose-response meta-analysis

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Qing Su ◽  
Xiaohui Sun ◽  
Liwen Zhu ◽  
Qin Yan ◽  
Peiwen Zheng ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Dose Response ◽  
Childhood Leukemia ◽  
Meta Analysis ◽  
Protective Role ◽  
Breastfeeding Duration ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Linear Dose ◽  
Non Linear

Abstract Background The aim of this study was to quantitatively summarize the available evidence on the association of breastfeeding with the risk of childhood cancer. Methods A literature search of PubMed and Embase databases was performed to identify eligible observational studies published from inception to July 17, 2020. The categorical and dose-response meta-analysis was conducted by pooling relative risk (RR) or odds ratio (OR) estimates with 95% confidence intervals (CIs). Potential sources of heterogeneity were detected by meta-regression and stratification analysis. Sensitivity analysis and publication bias test were also carried out. Results Forty-five articles involving 475,579 individuals were included in the meta-analysis. Among the thirty-three studies on the association between breastfeeding and risk of childhood leukemia, the pooled risk estimates were 0.77 (95% CI, 0.65–0.91) and 0.77 (95% CI 0.63–0.94) for ever versus non/occasional breastfeeding and longest versus shortest breastfeeding duration group, respectively. There was clear indication for non-linear dose-response relationship between breastfeeding duration and the risk of childhood leukemia (P non-linear < 0.001). The most protective effect (OR, 0.66, 95% CI 0.62–0.70) was observed at a breastfeeding duration of 9.6 months. Four studies examined, the association between breastfeeding and risk of childhood neuroblastoma, and significant inverse associations were consistently observed in both the comparisons of ever breastfeeding versus non/occasional breastfeeding (OR = 0.59, 95% CI 0.44–0.81) and longest versus shortest breastfeeding (OR = 0.61, 95% CI 0.44–0.83). However, no associations of breastfeeding with risk of other cancers were found. Conclusions Our study supports a protective role of breastfeeding on the risk of childhood leukemia, also suggesting a non-linear dose-response relationship. Further studies are warranted to confirm the association between breastfeeding and risk of childhood neuroblastoma.

scholarly journals Parity and Pancreatic Cancer Risk: A Dose-Response Meta-Analysis of Epidemiologic Studies

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e92738 ◽  
Author(s):  
Hong-Bo Guan ◽  
Lang Wu ◽  
Qi-Jun Wu ◽  
Jingjing Zhu ◽  
Tingting Gong
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Epidemiologic Studies ◽  
Pancreatic Cancer Risk
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