Meta-analysis: Serum vitamin D and breast cancer risk

2010 ◽  
Vol 46 (12) ◽  
pp. 2196-2205 ◽  
Author(s):  
Lu Yin ◽  
Norma Grandi ◽  
Elke Raum ◽  
Ulrike Haug ◽  
Volker Arndt ◽  
...  
2012 ◽  
Vol 4 (2) ◽  
pp. 152-157 ◽  
Author(s):  
Sharif B. Mohr ◽  
Edward D. Gorham ◽  
John E. Alcaraz ◽  
Christopher I. Kane ◽  
Caroline A. Macera ◽  
...  

2018 ◽  
Vol 70 (5) ◽  
pp. 804-820 ◽  
Author(s):  
Jessica L. Tommie ◽  
Susan M. Pinney ◽  
Laurie A. Nommsen-Rivers

2017 ◽  
Vol 11 ◽  
pp. 117822341774981 ◽  
Author(s):  
Manar Atoum ◽  
Foad Alzoughool

Vitamin D (the sunshine vitamin) plays a vital role in calcium homeostasis, skeletal metabolism, and immune, cardiovascular, and reproductive systems’ functions. The worldwide prevalence of vitamin D deficiency is approximately 1 billion. Vitamin D deficiency is a serious health problem with numerous health consequences; it is associated with diabetes, rheumatic arthritis, Parkinson, Alzheimer diseases, osteomalacia, osteoporosis, and fractures in adults and cancers. Many reports showed an inverse association between serum vitamin D concentration and incidence of several cancers, including breast, colorectal, kidney, lung, and pancreatic. About 20 different cancers have incidence rates inversely related to solar UV-B doses and serum vitamin D concentration. Considering the rising incidence of breast cancer and high prevalence of vitamin D deficiency, this review aimed to reflect an association between serum vitamin D concentration and breast cancer risk, reveal the link between vitamin D receptor genetic polymorphisms and breast cancer risk, and review the relationship between vitamin D level, breast cancer risk, and prognostic factors such as tumor stage, grade, size, lymph node involvement, and hormone receptor status.


2009 ◽  
Vol 30 (2) ◽  
pp. 113-125 ◽  
Author(s):  
L. YIN ◽  
N. GRANDI ◽  
E. RAUM ◽  
U. HAUG ◽  
V. ARNDT ◽  
...  

Tumor Biology ◽  
2013 ◽  
Vol 35 (1) ◽  
pp. 589-593 ◽  
Author(s):  
Jinjiang Xu ◽  
Hongyu Li ◽  
Lixue Gu ◽  
Xiaoping Zhou

2009 ◽  
Vol 33 (6) ◽  
pp. 435-445 ◽  
Author(s):  
Lu Yin ◽  
Elke Raum ◽  
Ulrike Haug ◽  
Volker Arndt ◽  
Hermann Brenner

2015 ◽  
Vol 36 (1) ◽  
pp. 299-305 ◽  
Author(s):  
Liqun Zhang ◽  
Sihai Wang ◽  
Xiaoyu Che ◽  
Xuehui Li

Background/Aim: Vitamin D has been suggested to have important roles against cancer development. There were several published studies on the association between vitamin D and lung cancer risk, but not conclusive results were available. Methods: To clarify the role of vitamin D in lung carcinogenesis, we performed a comprehensive review of the literature and a meta-analysis to evaluate the association of serum vitamin D levels and dietary vitamin D intake with lung cancer risk. Twelve studies (9 prospective cohort and 3 nested case-control studies) with a total of 288,778 individuals were included. The summary relative risk (RR) with 95% confidence interval (CI) was used to assess lung cancer risk. Results: Meta-analysis of total 12 studies showed that RR for the association of high vitamin D status with lung cancer was 0.84 (95%CI 0.78-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of serum vitamin D levels was 0.83 (95%CI 0.77-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of vitamin D intake was 0.89 (95%CI 0.74-1.06, P = 0.184). Conclusion: Current data suggest an inverse association between serum vitamin D and lung cancer risk. Further studies are needed to investigate the effect of vitamin D intake on lung cancer risk and to evaluate whether vitamin D supplementation can prevent lung cancer.


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