scholarly journals Vitamin D and Lung Cancer Risk: A Comprehensive Review and Meta-Analysis

2015 ◽  
Vol 36 (1) ◽  
pp. 299-305 ◽  
Author(s):  
Liqun Zhang ◽  
Sihai Wang ◽  
Xiaoyu Che ◽  
Xuehui Li
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Comprehensive Review ◽  
Serum Vitamin D ◽  
Vitamin D Intake ◽  
Vitamin D Levels

Background/Aim: Vitamin D has been suggested to have important roles against cancer development. There were several published studies on the association between vitamin D and lung cancer risk, but not conclusive results were available. Methods: To clarify the role of vitamin D in lung carcinogenesis, we performed a comprehensive review of the literature and a meta-analysis to evaluate the association of serum vitamin D levels and dietary vitamin D intake with lung cancer risk. Twelve studies (9 prospective cohort and 3 nested case-control studies) with a total of 288,778 individuals were included. The summary relative risk (RR) with 95% confidence interval (CI) was used to assess lung cancer risk. Results: Meta-analysis of total 12 studies showed that RR for the association of high vitamin D status with lung cancer was 0.84 (95%CI 0.78-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of serum vitamin D levels was 0.83 (95%CI 0.77-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of vitamin D intake was 0.89 (95%CI 0.74-1.06, P = 0.184). Conclusion: Current data suggest an inverse association between serum vitamin D and lung cancer risk. Further studies are needed to investigate the effect of vitamin D intake on lung cancer risk and to evaluate whether vitamin D supplementation can prevent lung cancer.

Serum vitamin D levels in females with urinary incontinence: a meta-analysis of observational trials

2021 ◽  
Author(s):  
Chih-Chen Hsu ◽  
Yu-Chen Huang ◽  
Syuan-Hao Syu ◽  
Hung-Jen Shih ◽  
Yung-Wei Lin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Urinary Incontinence ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Meta-analysis of vitamin D and lung function in patients with asthma

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Jian Liu ◽  
Yong-Quan Dong ◽  
Jie Yin ◽  
Jian Yao ◽  
Jie Shen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Lung Function ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Forced Expiratory Volume ◽  
Asthma Control Test ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Asthma Patients ◽  
Sufficient Vitamin

Abstract Background There is growing literature suggesting a link between vitamin D and asthma lung function, but the results from systematic reviews are conflicting. We conducted this meta-analysis to investigate the relation between serum vitamin D and lung function in asthma patients. Methods Major databases, including OVID, MEDLINE, Web of Science and PUBMED, were searched until 10th October 2018. All published observational studies related to vitamin D and asthma were extracted. All meta-analyses were performed using Review Manager 5.3.5. Results This quantitative synthesis found that asthma patients with low vitamin D levels had lower forced expiratory volume In 1 s (FEV1) (mean difference (MD) = − 0.1, 95% CI = − 0.11 to − 0.08,p < 0.01;I2 = 49%, p = 0.12) and FEV1% (MD = − 10.02, 95% CI = − 11 to − 9.04, p < 0.01; I2 = 0%, p = 0.82) than those with sufficient vitamin D levels. A positive relation was found between vitamin D and FEV1 (r = 0.12, 95% CI = 0.04 to 0.2, p = 0.003; I2 = 59%,p = 0.01), FEV1% (r = 0.19, 95% CI = 0.13 to 0.26, p < 0.001; I2 = 42%, p = 0.11), forced vital capacity (FVC) (r = 0.17, 95% CI = 0.00 to 0.34, p = 0.05; I2 = 60%, p = 0.04), FEV1/FVC (r = 0.4, 95% CI = 0.3 to 0.51, p < 0.001; I2 = 48%, p = 0.07), and the asthma control test (ACT) (r = 0.33, 95% CI = 0.2 to 0.47, p < 0.001; I2 = 0%, p = 0.7). Subgroup analysis indicated that the positive correlation between vitamin D and lung function remained significant in both children and adults. Conclusions Our meta-analysis suggested that serum vitamin D levels may be positively correlated with lung function in asthma patients. Future comprehensive studies are required to confirm these relations and to elucidate potential mechanisms.

scholarly journals Meta-analysis of the correlation between vitamin D and lung cancer risk and outcomes

Oncotarget ◽  
2017 ◽  
Vol 8 (46) ◽  
pp. 81040-81051 ◽  
Author(s):  
Jian Liu ◽  
Yongquan Dong ◽  
Chao Lu ◽  
Yina Wang ◽  
Ling Peng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis

Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk

2009 ◽  
Vol 30 (2) ◽  
pp. 113-125 ◽  
Author(s):  
L. YIN ◽  
N. GRANDI ◽  
E. RAUM ◽  
U. HAUG ◽  
V. ARNDT ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Longitudinal Studies ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Colorectal Cancer Risk ◽  
Serum Vitamin D
Sign in / Sign up

Export Citation Format

Share Document