Association between CYP2E1 genetic polymorphisms and lung cancer risk: A meta-analysis

2010 ◽  
Vol 46 (4) ◽  
pp. 758-764 ◽  
Author(s):  
Yadong Wang ◽  
Haiyan Yang ◽  
Li Li ◽  
Haiyu Wang ◽  
Congke Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Lung Cancer Risk ◽  
Meta Analysis

scholarly journals Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis

2010 ◽  
Vol 2010 ◽  
pp. 1-17 ◽  
Author(s):  
Chikako Kiyohara ◽  
Koichi Takayama ◽  
Yoichi Nakanishi
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Lung Cancer Risk ◽  
Excision Repair ◽  
Meta Analysis ◽  
Epidemiologic Studies ◽  
Repair Capacity ◽  
Repair Pathways

Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk. We conducted a meta-analysis of epidemiologic studies on the association between genetic polymorphisms in both base excision repair and nucleotide excision repair pathways, and lung cancer. We found xeroderma pigmentosum complementation group A (XPA) G23A (odds ratio (OR)=0.76, 95% confidence interval (CI)=0.61–0.94), 8-oxoguanine DNA glycosylase 1 (OGG1) Ser326Cys (OR=1.22, 95% CI=1.02–1.45), and excision repair cross-complementing group 2 (ERCC2) Lys751Gln (OR=1.27, 95% CI=1.10–1.46) polymorphisms were associated with lung cancer risk. Considering the data available, it can be conjectured that if there is any risk association between a single SNP and lung cancer, the risk fluctuation will probably be minimal. Advances in the identification of new polymorphisms and in high-throughput genotyping techniques will facilitate the analysis of multiple genes in multiple DNA repair pathways. Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples of cases and controls.

scholarly journals Associations between female lung cancer risk and sex steroid hormones: a systematic review and meta-analysis of the worldwide epidemiological evidence on endogenous and exogenous sex steroid hormones

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hui Zeng ◽  
Zhuoyu Yang ◽  
Jiang Li ◽  
Yan Wen ◽  
Zheng Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Steroid Hormones ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
Hormone Exposure ◽  
Female Lung Cancer

Abstract Background Published findings suggest sex differences in lung cancer risk and a potential role for sex steroid hormones. Our aim was to perform a meta-analysis to investigate the effects of sex steroid hormone exposure specifically on the risk of lung cancer in women. Methods The PubMed, MEDLINE, Web of Science, and EMBASE databases were searched. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for female lung cancer risk associated with sex steroid hormones were calculated overall and by study design, publication year, population, and smoking status. Sensitivity analysis, publication bias, and subgroup analysis were performed. Results Forty-eight studies published between 1987 and 2019 were included in the study with a total of 31,592 female lung cancer cases and 1,416,320 subjects without lung cancer. Overall, higher levels of sex steroid hormones, both endogenous (OR: 0.92, 95% CI: 0.87–0.98) and exogenous (OR: 0.86, 95% CI: 0.80–0.93), significantly decreased the risk of female lung cancer by 10% (OR: 0.90, 95% CI: 0.86–0.95). The risk of lung cancer decreased more significantly with a higher level of sex steroid hormones in non-smoking women (OR: 0.88, 95% CI: 0.78–0.99) than in smoking women (OR: 0.98, 95% CI: 0.77–1.03), especially in Asia women (OR: 0.84, 95% CI: 0.74–0.96). Conclusions Our meta-analysis reveals an association between higher levels of sex steroid hormone exposure and the decreased risk of female lung cancer. Surveillance of sex steroid hormones might be used for identifying populations at high risk for lung cancer, especially among non-smoking women.

CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population

Life Sciences ◽  
2009 ◽  
Vol 84 (21-22) ◽  
pp. 779-784 ◽  
Author(s):  
Fatma B'chir ◽  
Sofia Pavanello ◽  
Jalel Knani ◽  
Sami Boughattas ◽  
Maurice J. Arnaud ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Lung Cancer Risk ◽  
Tunisian Population

scholarly journals Genetic polymorphisms of XPD and CDA and lung cancer risk

2012 ◽  
Vol 4 (2) ◽  
pp. 247-251 ◽  
Author(s):  
MIN ZHOU ◽  
HUAN-YING WAN ◽  
BEI-LI GAO ◽  
YONG-JIE DING ◽  
RONG-XIA JUN
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Lung Cancer Risk

scholarly journals Association of RASSF1A Promoter Methylation with Lung Cancer Risk: a Meta-analysis

2015 ◽  
Vol 15 (23) ◽  
pp. 10325-10328 ◽  
Author(s):  
Ying-Ze Huang ◽  
Wei Wu ◽  
Kun Wu ◽  
Xiao-Ning Xu ◽  
Wen-Ru Tang
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Promoter Methylation ◽  
Lung Cancer Risk ◽  
Meta Analysis

GSTM1 polymorphism and lung cancer risk among East Asian populations: a meta-analysis

Tumor Biology ◽  
2014 ◽  
Vol 35 (7) ◽  
pp. 6493-6500 ◽  
Author(s):  
Yan Zhao ◽  
Junjie Zeng ◽  
Yanxi Zhang ◽  
Su Lu ◽  
Erjiang Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
East Asian ◽  
Asian Populations ◽  
Gstm1 Polymorphism
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