Clinical and histopathological risk factors to predict sentinel lymph node positivity, disease-free and overall survival in clinical stages I–II AJCC skin melanoma: Outcome analysis from a single-institution prospectively collected database

2009 ◽  
Vol 45 (14) ◽  
pp. 2537-2545 ◽  
Author(s):  
M. Mandalà ◽  
G.L. Imberti ◽  
D. Piazzalunga ◽  
M. Belfiglio ◽  
R. Labianca ◽  
...  
Keyword(s):  
Risk Factors ◽  
Overall Survival ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Outcome Analysis ◽  
Skin Melanoma ◽  
Single Institution ◽  
Clinical Stages ◽  
Sentinel Lymph Node Positivity ◽  
Disease Free

Reduced expression of plakoglobin indicates an unfavorable prognosis in subsets of patients with non-small-cell lung cancer.

1998 ◽  
Vol 16 (4) ◽  
pp. 1407-1413 ◽  
Author(s):  
K Pantel ◽  
B Passlick ◽  
J Vogt ◽  
P Stosiek ◽  
M Angstwurm ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lung Cancer ◽  
Overall Survival ◽  
Cell Adhesion ◽  
Lymph Node ◽  
Tumor Cells ◽  
Primary Tumor ◽  
Small Cell ◽  
Small Cell Lung ◽  
Disease Free

PURPOSE Plakoglobin is thought to play a key role in cadherin-mediated epithelial cell adhesion, because it is a common component of desmosomal and nondesmosomal adherens junctions. Because loss of homotypic cell adhesion is an important early step in invasion and metastasis of solid tumors, we evaluated the frequency and prognostic significance of a deficient expression of plakoglobin in human lung cancer. PATIENTS AND METHODS At primary surgery, representative specimens of the primary tumor were obtained from 96 consecutive patients with completely resected non-small-cell lung carcinoma (NSCLC) without overt distant metastases. Cryostat sections of these specimens and metastatic lymph nodes were stained with monoclonal antibody (mAb) PG 5.1 against plakoglobin, using an immunoperoxidase technique. Patients were monitored for a median of 39 months (range, 12 to 56) after surgery. RESULTS Absent or severely reduced expression of plakoglobin (ie, < 30% positive tumor cells) was observed in 39 patients (40.6%). There was no significant correlation to established risk factors, such as the histology, extension, and histologic grade of the primary tumor and metastatic lymph node involvement, or expression of alpha-catenin. Expression of plakoglobin in lymph node metastases ranged from 0% to greater than 60% positive tumor cells. Deficient plakoglobin expression on the primary tumor was significantly correlated to a shortened disease-free and overall survival in patients with adenocarcinomas, pT1-2 tumors, or negative lymph nodes (pN0). In patients with pT1-2 tumors, the independence of this prognostic influence from established risk factors was demonstrated by Cox regression analyses (disease-free survival, P = .002; overall survival, P = .038). CONCLUSION Deficient expression of plakoglobin appears to be an important event in the progression of NSCLC.

Neck Dissections Based on Sentinel Lymph Node Navigation Versus Elective Neck Dissections in Early Oral Cancers: A Randomized, Multicenter, and Noninferiority Trial

2021 ◽  
pp. JCO.20.03637
Author(s):  
Yasuhisa Hasegawa ◽  
Kiyoaki Tsukahara ◽  
Seiichi Yoshimoto ◽  
Kouki Miura ◽  
Junkichi Yokoyama ◽  
...  
Keyword(s):  
Overall Survival ◽  
Lymph Node ◽  
Survival Rate ◽  
Sentinel Lymph Node ◽  
Lower Limit ◽  
Disease Free Survival ◽  
Sentinel Lymph Nodes ◽  
Free Survival ◽  
Node Negative ◽  
Disease Free

PURPOSE This study aimed to compare patients with early oral cavity squamous cell carcinoma (OCSCC) (tumor category [T] 1-2, node-negative, and no distant metastasis) treated with traditional elective neck dissection (ND) with those managed by sentinel lymph node biopsy (SLNB) using survival and neck function and complications as end points. METHODS Sixteen institutions in Japan participated in the study (trial registration number: UMIN000006510). Patients of age ≥ 18 years with histologically confirmed, previously untreated OCSCC (Union for International Cancer Control TNM Classification of Malignant Tumors 7th edition T1-2, node-negative no distant metastasis), with ≥ 4 mm (T1) depth of invasion, were randomly assigned to undergo standard selective ND (ND group; n = 137) or SLNB-navigated ND (SLNB group; n = 134). The primary end point was the 3-year overall survival rate, with a 12% noninferiority margin; secondary end points included postoperative neck functionality and complications and 3-year disease-free survival. Sentinel lymph nodes underwent intraoperative multislice frozen section analyses for the diagnosis. Patients with positive sentinel lymph nodes underwent either one-stage or second-look ND. RESULTS Pathologic metastasis-positive nodes were observed in 24.8% (34 of 137) and 33.6% (46 of 134) of patients in the ND and SLNB groups, respectively ( P = .190). The 3-year overall survival in the SLNB group (87.9%; lower limit of one-sided 95% CI, 82.4) was noninferior to that in the ND group (86.6%; lower limit 95% CI, 80.9; P for noninferiority < .001). The 3-year disease-free survival rate was 78.7% (lower limit 95% CI, 72.1) and 81.3% (75.0) in the SLNB and ND groups, respectively ( P for noninferiority < .001). The scores of neck functionality in the SLNB group were significantly better than those in the ND group. CONCLUSION SLNB-navigated ND may replace elective ND without a survival disadvantage and reduce postoperative neck disability in patients with early-stage OCSCC.

Sentinel Lymph Node Dissection in Head and Neck Melanoma has Prognostic Impact on Disease-Free and Overall Survival

2015 ◽  
Vol 22 (12) ◽  
pp. 4073-4080 ◽  
Author(s):  
Ulrike Leiter ◽  
Thomas K. Eigentler ◽  
Hans-Martin Häfner ◽  
Michael Krimmel ◽  
Ugur Uslu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Head And Neck ◽  
Lymph Node Dissection ◽  
Sentinel Lymph Node Dissection ◽  
Prognostic Impact ◽  
Node Dissection ◽  
Head And Neck Melanoma ◽  
Disease Free
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