Functional responses and in vivo anti-tumour activity of h7C10: A humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors

Giuseppe Pandini; Thierry Wurch; Barbara Akla; Nathalie Corvaia; Antonino Belfiore; Liliane Goetsch

doi:10.1016/j.ejca.2007.03.009

Functional responses and in vivo anti-tumour activity of h7C10: A humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors

European Journal of Cancer ◽

10.1016/j.ejca.2007.03.009 ◽

2007 ◽

Vol 43 (8) ◽

pp. 1318-1327 ◽

Cited By ~ 43

Author(s):

Giuseppe Pandini ◽

Thierry Wurch ◽

Barbara Akla ◽

Nathalie Corvaia ◽

Antonino Belfiore ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Insulin Like Growth Factor ◽

Functional Responses ◽

Anti Tumour Activity ◽

Tumour Activity

Download Full-text

195 POSTER In vitro and in vivo inhibition of functional responses at insulin-like growth factor-1/insulin hybrid receptors by h7C10, a novel humanized anti-IGF-1R monoclonal antibody

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(06)70200-2 ◽

2006 ◽

Vol 4 (12) ◽

pp. 61 ◽

Cited By ~ 1

Author(s):

T. Wurch ◽

G. Pandini ◽

B. Akla ◽

N. Corvaia ◽

A. Belfiore ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Insulin Like Growth Factor ◽

Functional Responses

Download Full-text

Anti-insulin-like growth factor 1 receptor antibody EM164 (murine AVE1642) exhibits anti-tumour activity alone and in combination with temozolomide against neuroblastoma

European Journal of Cancer ◽

10.1016/j.ejca.2010.06.005 ◽

2010 ◽

Vol 46 (18) ◽

pp. 3251-3262 ◽

Cited By ~ 17

Author(s):

Birgit Geoerger ◽

Jean-François Brasme ◽

Estelle Daudigeos-Dubus ◽

Paule Opolon ◽

Corinne Venot ◽

...

Keyword(s):

Growth Factor ◽

Insulin Like Growth Factor ◽

Receptor Antibody ◽

Anti Tumour Activity ◽

Tumour Activity

Download Full-text

Anti-tumour activity of aminopterin-monoclonal antibody conjugates; in vitro and in vivo comparison with methotrexate-monoclonal antibody conjugates

Immunology and Cell Biology ◽

10.1038/icb.1987.57 ◽

1987 ◽

Vol 65 (6) ◽

pp. 483-493 ◽

Cited By ~ 19

Author(s):

Jerry Kanellos ◽

Geoffrey A Pietersz ◽

Zita Cunningham ◽

Ian FC McKenzie

Keyword(s):

Monoclonal Antibody ◽

Anti Tumour Activity ◽

Antibody Conjugates ◽

Tumour Activity

Download Full-text

Faculty Opinions recommendation of A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1120094.576229 ◽

2008 ◽

Author(s):

Richard Riedel

Keyword(s):

Growth Factor ◽

Heat Shock ◽

Heat Shock Protein ◽

Ewing Sarcoma ◽

Heat Shock Protein 90 ◽

Pivotal Role ◽

In Vivo Study ◽

Insulin Like Growth Factor

Download Full-text

Faculty Opinions recommendation of R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13407996.14851092 ◽

2012 ◽

Author(s):

Florence Duffaud

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Phase Ii ◽

Ewing Sarcoma ◽

Insulin Like Growth Factor

Download Full-text

Relationship Between Growth Hormone in vivo Bioactivity, the Insulin-Like Growth Factor-I System and Bone Mineral Density in Young, Physically Fit Men and Women

10.21236/ada487963 ◽

2008 ◽

Author(s):

B. C. Nindl ◽

J. R. Pierce ◽

M. J. Durkot ◽

A. P. Tuckow ◽

M. J. Kennett ◽

...

Keyword(s):

Bone Mineral Density ◽

Growth Hormone ◽

Growth Factor ◽

Bone Mineral ◽

Insulin Like Growth Factor ◽

Mineral Density ◽

Men And Women ◽

Factor I ◽

Growth Factor I

Download Full-text

Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(20)89644-6 ◽

1991 ◽

Vol 266 (11) ◽

pp. 7300-7305

Author(s):

H L Foyt ◽

D LeRoith ◽

C T Roberts

Keyword(s):

Growth Factor ◽

Differential Association ◽

Insulin Like Growth Factor ◽

Factor I ◽

Mrna Variants ◽

Growth Factor I

Download Full-text

Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: A predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas

European Journal of Cancer ◽

10.1016/j.ejca.2012.05.009 ◽

2012 ◽

Vol 48 (16) ◽

pp. 3027-3035 ◽

Cited By ~ 68

Author(s):

Irène Asmane ◽

Emmanuel Watkin ◽

Laurent Alberti ◽

Adeline Duc ◽

Perrine Marec-Berard ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Predictive Biomarker ◽

Nuclear Staining ◽

Insulin Like Growth Factor ◽

Factor Type

Download Full-text

Insulin-like growth factor-1-mediated association of p85 phosphatidylinositol 3-kinase with pp 185: requirement of SH2 domains for in vivo interaction.

Molecular Endocrinology ◽

10.1210/mend.8.9.7838146 ◽

1994 ◽

Vol 8 (9) ◽

pp. 1139-1146

Author(s):

D Altschuler ◽

K Yamamoto ◽

E G Lapetina

Keyword(s):

Growth Factor ◽

Insulin Like Growth Factor ◽

Phosphatidylinositol 3 Kinase ◽

Sh2 Domains ◽

Phosphatidylinositol 3

Download Full-text

Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity

Journal of Medicinal Chemistry ◽

10.1021/jm050392q ◽

2005 ◽

Vol 48 (18) ◽

pp. 5639-5643 ◽

Cited By ~ 94

Author(s):

Mark Wittman ◽

Joan Carboni ◽

Ricardo Attar ◽

Balu Balasubramanian ◽

Praveen Balimane ◽

...

Keyword(s):

Growth Factor ◽

Antitumor Activity ◽

Insulin Like Growth Factor ◽

Receptor Kinase ◽

Factor I ◽

In Vivo Antitumor Activity ◽

Growth Factor I

Download Full-text