Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: A predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas

2012 ◽  
Vol 48 (16) ◽  
pp. 3027-3035 ◽  
Author(s):  
Irène Asmane ◽  
Emmanuel Watkin ◽  
Laurent Alberti ◽  
Adeline Duc ◽  
Perrine Marec-Berard ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Growth Factor ◽  
Predictive Biomarker ◽  
Nuclear Staining ◽  
Insulin Like Growth Factor ◽  
Factor Type

Production and Characterization of Monoclonal Antibodies Against Insulin-Like Growth Factor Type 1 Receptor

Hybridoma ◽  
2006 ◽  
Vol 25 (4) ◽  
pp. 230-237 ◽  
Author(s):  
Mehrnaz Keyhanfar ◽  
Briony E. Forbes ◽  
Leah J. Cosgrove ◽  
John C. Wallace ◽  
Grant W. Booker
Keyword(s):  
Monoclonal Antibodies ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Factor Type

Expression of Insulin-like Growth Factor Type 1 Receptor is Linked to Inflammation in Adamantinomatous Craniopharyngioma

2021 ◽  
Author(s):  
Lang Yang ◽  
Kai Li ◽  
Weizhao Li ◽  
Chaohu Wang ◽  
Yi Liu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
High Expression ◽  
Inflammatory Factors ◽  
Insulin Like Growth Factor ◽  
Factor Type ◽  
Adamantinomatous Craniopharyngioma ◽  
The Relationship ◽  
Igf1r Expression

Introduction Insulin-like growth factor type 1 receptor (IGF1R) is overexpressed in various malignant tumors, which relates to their transformation and recurrence. Craniopharyngioma is a benign tumor with malignant results, often accompanied by a severe inflammatory reaction. However, the relationship between IGF1R expression and the inflammatory response of craniopharyngioma is unclear. Methods We enrolled 85 patients with adamantinomatous craniopharyngioma (ACP) in a study to explore the relationship between IGF1R expression and clinical features of this disease. Results Patients in the IGF1R high expression group had a significantly higher incidence of hypopituitarism, higher recurrence rate and lower progression-free survival. Beta-catenin can further regulate expression of the stem cell marker, CD44, by regulating IGF1R. Using immunofluorescence, we found that tumor stem cell–like cells did not express phosphorylated (p)-ERK, although p-ERK activation was evident in the surrounding cells. Picropodophyllin, a specific inhibitor of IGF1R, increased the expression of p-ERK protein, and decreased the transcription level of interleukin-6. Conclusions High expression of IGF1R might promote inflammation of ACP, which might be an unfavorable factor for pituitary function and prognosis. The high expression of IGF1R in tumor cell stem-like cells might inhibit the expression of p-ERK and promote the generation of inflammatory factors. Insulin-like growth factor type 1 receptor plays a stemness maintenance role in ACP and regulates the production of inflammatory factors through a p-ERK pathway, which suggests that targeting IGF1R and p-ERK might provide a new direction for alleviating tumor inflammation.

scholarly journals A study of serum insulin-like growth factor type 1 (IGF-1) concentrations in resting untrained Andalusian horses: influence of age and gender

2011 ◽  
Vol 56 (No. 5) ◽  
pp. 231-242 ◽  
Author(s):  
A. Munoz ◽  
P. Trigo ◽  
C. Riber ◽  
V. Malonda ◽  
F. Castejon
Keyword(s):  
Body Size ◽  
Growth Factor ◽  
Sandwich Elisa ◽  
Age Groups ◽  
Accurate Information ◽  
Insulin Like Growth Factor ◽  
Factor Type ◽  
Age And Sex ◽  
Somatotrophic Axis

Growth rate, tissue repair and reproductive functions are mediated by the somatotrophic axis, the growth hormone (GH) being one of its main components. GH is released in a pulsatile manner and a single measurement does not provide accurate information on the activity of the somatotrophic axis. The actions of GH on tissues are mediated by insulin-like growth factor type 1 (IGF-1), mainly released by the liver, and thus, the measurement of IGF-1 could be considered a good indicator of the activity of GH and the somatotrophic axis. Serum IGF-1 concentrations are relatively stable due to its long biological half-life without obvious diurnal rhythm. Additionally, many diseases significantly alter circulating IGF-1 concentrations, leading to potential diagnostic and prognostic uses in veterinary medicine. However, serum IGF-1 concentrations are affected by many factors, such as breed, age and sex. The present study analyzes the influence of these factors on serum IGF-1 concentrations in a population of 255 Andalusian horses (141 females and 114 males), divided into age groups: 1–2, 2–3, 3–4, 4–5, 5–6 and 6–12 months and 1–2, 2–4, 4–6, 6–10 and 10–14 years. The animals belonged to six different farms located in the same geographic location and were subjected to similar feeding and management protocols. Two measurements of body size were made: height at the withers (HW) and diameter of the thorax (DTx). Blood samples were taken always in the morning, in the month of July and serum IGF-1 concentrations were measured with a sandwich ELISA after dissociation of IGF-1 from its binding proteins. It was found that age and sex significantly influenced serum IGF-1 concentrations, whereas the effects of the farm and the time of blood withdrawal were not significant. Mean serum concentrations for both males and females respectively were: 246.3 and 231.0 (1–2 months), 201.9 and 194.7 (2–3 months), 174.2 and 170.4 (3–4 months), 161.7 and 155.4 (4–5 months), 166.1 and 136.9 (5–6 months), 127.2–114.5 (6–12 months), 103.3 and 89.01 (1–2 years), 104.3 and 73.41 (2–4 years), 105.4 and 64.40 (4–6 years), 53.29 and 68.27 (6–10 years) and 59.56 and 65.53 ng/ml (10–14 years). A progressive decrease in serum IGF-1 concentrations with increased age was found for both sexes. Males aged between five and 12 months and between two and six years had significantly higher serum IGF-1 concentrations than females of the same age. Coefficients of correlation between the indicators of body size (HW and DTx) and IGF-1 were –0.800 and –0.690 for the whole population of Andalusian horses, –0.860 and –0.750 for the males and –0.740 and –630 for the females. It is concluded that serum IGF-1 concentrations in Andalusian horses are reduced with ageing, male horses of determined age groups had higher IGF-1 than the females and there are negative correlations between body size and IGF-1 concentrations. The knowledge of the normal serum IGF-1 concentrations will help us to understand the role of the somatotrophic axis in several diseases and physiological situations and will provide information for further research on this equine breed.

scholarly journals Evaluation of 99mTc-ZIGF1R:4551-GGGC affibody molecule, a new probe for imaging of insulin-like growth factor type 1 receptor expression

Amino Acids ◽  
2014 ◽  
Vol 47 (2) ◽  
pp. 303-315 ◽  
Author(s):  
Bogdan Mitran ◽  
Mohamed Altai ◽  
Camilla Hofström ◽  
Hadis Honarvar ◽  
Mattias Sandström ◽  
...  
Keyword(s):  
Growth Factor ◽  
Receptor Expression ◽  
Insulin Like Growth Factor ◽  
Affibody Molecule ◽  
Factor Type

scholarly journals Disruption of the Insulin-like Growth Factor Type 1 Receptor in Osteoblasts Enhances Insulin Signaling and Action

2007 ◽  
Vol 282 (35) ◽  
pp. 25649-25658 ◽  
Author(s):  
Keertik Fulzele ◽  
Douglas J. DiGirolamo ◽  
Zhongyu Liu ◽  
Jie Xu ◽  
Joseph L. Messina ◽  
...  
Keyword(s):  
Growth Factor ◽  
Insulin Signaling ◽  
Insulin Like Growth Factor ◽  
Factor Type
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