Long non-coding RNAs as a determinant of cancer drug resistance: Towards the overcoming of chemoresistance via modulation of lncRNAs

2020 ◽  
Vol 50 ◽  
pp. 100683 ◽  
Author(s):  
Wenxiao Jiang ◽  
Jun Xia ◽  
Shangdan Xie ◽  
Ruanmin Zou ◽  
Shuya Pan ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Drug ◽  
Cancer Drug Resistance ◽  
Non Coding Rnas

scholarly journals The role of exosomal long non-coding RNAs in cancer drug resistance

2019 ◽  
Author(s):  
Mireia Cruz De los Santos ◽  
Mihnea P. Dragomir ◽  
George A. Calin
Keyword(s):  
Drug Resistance ◽  
Cancer Drug ◽  
Cancer Drug Resistance ◽  
Non Coding Rnas

scholarly journals Novel Implications of MicroRNAs, Long Non-coding RNAs and Circular RNAs in Drug Resistance of Esophageal Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Ling Wei ◽  
Jujie Sun ◽  
Nasha Zhang ◽  
Yue Shen ◽  
Teng Wang ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Esophageal Cancer ◽  
Checkpoint Inhibitors ◽  
Cancer Drug ◽  
Circular Rnas ◽  
Cancer Drug Resistance ◽  
Novel Biomarkers ◽  
Non Coding Rnas ◽  
Underlying Mechanisms ◽  
Poor Outcomes

Esophageal cancer is the eighth most common malignancy and the sixth leading cause of cancer-related deaths worldwide. Chemotherapy based on platinum drugs, 5-fluorouracil, adriamycin, paclitaxel, gemcitabine, and vinorelbine, as well as targeted treatment and immunotherapy with immune checkpoint inhibitors improved the prognosis in a portion of patients with advanced esophageal cancer. Unfortunately, a number of esophageal cancer patients develop drug resistance, resulting in poor outcomes. Multiple mechanisms contributing to drug resistance of esophageal cancer have been reported. Notably, non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), have been identified to play crucial roles in modulating esophageal cancer drug resistance. In the present review, we highlight the underlying mechanisms how miRNAs, lncRNAs, and circRNAs impact the drug resistance of esophageal cancer. Several miRNAs, lncRNAs, and circRNAs may have potential clinical implications as novel biomarkers and therapeutic targets for esophageal cancer.

scholarly journals The Network of Non-coding RNAs in Cancer Drug Resistance

2018 ◽  
Vol 8 ◽  
Author(s):  
Fabio Corrà ◽  
Chiara Agnoletto ◽  
Linda Minotti ◽  
Federica Baldassari ◽  
Stefano Volinia
Keyword(s):  
Drug Resistance ◽  
Cancer Drug ◽  
Cancer Drug Resistance ◽  
Non Coding Rnas

scholarly journals Long non-coding RNAs in anti-cancer drug resistance

Oncotarget ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 1925-1936 ◽  
Author(s):  
Qin-nan Chen ◽  
Chen-chen Wei ◽  
Zhao-xia Wang ◽  
Ming Sun
Keyword(s):  
Drug Resistance ◽  
Cancer Drug ◽  
Cancer Drug Resistance ◽  
Anti Cancer ◽  
Non Coding Rnas

Fanconi Anemia DNA Repair Pathway as a New Mechanism to Exploit Cancer Drug Resistance

2020 ◽  
Vol 20 (9) ◽  
pp. 779-787
Author(s):  
Kajal Ghosal ◽  
Christian Agatemor ◽  
Richard I. Han ◽  
Amy T. Ku ◽  
Sabu Thomas ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Dna Repair ◽  
Fanconi Anemia ◽  
Cancer Drug ◽  
Drug Resistant ◽  
Cancer Drugs ◽  
Repair Pathway ◽  
Cancer Drug Resistance ◽  
Anti Cancer ◽  
Cancerous Cells

Chemotherapy employs anti-cancer drugs to stop the growth of cancerous cells, but one common obstacle to the success is the development of chemoresistance, which leads to failure of the previously effective anti-cancer drugs. Resistance arises from different mechanistic pathways, and in this critical review, we focus on the Fanconi Anemia (FA) pathway in chemoresistance. This pathway has yet to be intensively researched by mainstream cancer researchers. This review aims to inspire a new thrust toward the contribution of the FA pathway to drug resistance in cancer. We believe an indepth understanding of this pathway will open new frontiers to effectively treat drug-resistant cancer.

scholarly journals Recent Progress in Characterizing Long Noncoding RNAs in Cancer Drug Resistance

2019 ◽  
Vol 10 (26) ◽  
pp. 6693-6702 ◽  
Author(s):  
Wenyuan Zhao ◽  
Bin Shan ◽  
Dan He ◽  
Yuanda Cheng ◽  
Bin Li ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Recent Progress ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Cancer Drug ◽  
Cancer Drug Resistance

Nanoparticle-based drug delivery systems with platinum drugs for overcoming cancer drug resistance

2021 ◽  
Author(s):  
Peng Xie ◽  
Yushu Wang ◽  
Dengshuai Wei ◽  
Lingpu Zhang ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Platinum Drugs ◽  
Effective Strategy ◽  
Platinum Drug ◽  
Cancer Drug Resistance ◽  
Platinum Drug Resistance

The mechanisms of chemoresistance and nanoparticle-based drug delivery systems for platinum drugs were detailed summarized in this review. The current combination therapy provided an effective strategy to overcome the platinum drug resistance.

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